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Virus-like Particles as Antiviral Vaccine: Mechanism, Design, and Application
Virus-like particles (VLPs) are viral structural protein that are noninfectious as they do not contain viral genetic materials. They are safe and...
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Targeted Cancer Therapy: KRAS-Specific Treatments for Pancreatic Cancer
Pancreatic cancer is highly dependent on the activity of the KRAS oncogene, which controls the redox homeostasis and induces metabolic reprogramming....
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Engineering of Plants for Efficient Production of Therapeutics
Plants are becoming useful platforms for recombinant protein production at present time. With the advancement of efficient molecular tools of...
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Aptasensors for the detection of infectious pathogens: design strategies and point-of-care testing
The epidemic of infectious diseases caused by contagious pathogens is a life-threatening hazard to the entire human population worldwide. A timely...
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Thermal characterization and stability evaluation of leishmanicidal selenocyanate and diselenide derivatives
In this study, the thermal behavior of a series of leishmanicidal selenocyanate and diselenide biological active compounds has been studied by means...
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Design, synthesis, antitubercular and antiviral properties of new spirocyclic indole derivatives
AbstractA series of indole-based spirothiazolidinones have been designed, synthesized and evaluated, in vitro, for their antitubercular, antiviral,...
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Selection and applications of functional nucleic acids for infectious disease detection and prevention
Infectious diseases caused by pathogenic microorganisms such as viruses and bacteria pose a great threat to human health. Although a significant...
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An insight to the molecular interactions of the FDA approved HIV PR drugs against L38L↑N↑L PR mutant
The aspartate protease of the human immune deficiency type-1 virus (HIV-1) has become a crucial antiviral target in which many useful antiretroviral...
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Migraine drugs
According to recent studies, migraine affects more than 1 billion people worldwide, making it one of the world’s most prevalent diseases. Although...
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Interaction of 1-methyl-1-({2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-4-yl}methyl) piperidinium chloride with β-CD: spectroscopic, calorimetric and molecular modeling approaches
Spectroscopic investigation supported by molecular modeling methods has been used to describe the inclusion complex of β-cyclodextrin (β-CD) with...
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Biosensor for Rapid and Sensitive Detection of Influenza Virus
Influenza viruses continue to threaten human life, causing considerable damage socially and economically. To reduce influenza-related morbidity and...
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Goose, Duck and Garganey
Duck, goose and garganey are waterfowls consumed in a lower proportion than chicken. These species are of great economic importance in Asia, Europe...
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Applications of Molecular Dynamics Simulations in Computational Toxicology
Computational toxicologyComputational toxicology is a discipline seeking to computationally modelModel and predict toxicity of chemicals including...
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Microdroplet Array for Nucleic Acid Amplification Strategies
Nucleic acid amplificationNucleic acid amplification strategies are often integrated with miniaturized devices including digital...
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Simultaneous subty** and pathoty** of the novel reassortant influenza A (H5N8) virus from clinical samples using a diagnostic microarray
Highly pathogenic avian influenza (HPAI) viruses cause economic losses in the poultry industry and pose a severe threat to human health. Rapid and...
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Quantum Dot bioconjugates for diagnostic applications
Quantum dots (QDs) are a special type of engineered nanomaterials with outstanding optoelectronic properties that make them as a very promising...
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Allosteric mechanisms underlie GPCR signaling to SH3-domain proteins through arrestin
Signals from 800 G-protein-coupled receptors (GPCRs) to many SH3 domain-containing proteins (SH3-CPs) regulate important physiological functions....
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Nanodiamond enhances immune responses in mice against recombinant HA/H7N9 protein
BackgroundThe continuing spread of the newly emerged H7N9 virus among poultry in China, as well as the possibility of human-to-human transmission,...
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Antagonist-perturbation mechanism for activation function-2 fixed motifs: active conformation and docking mode of retinoid X receptor antagonists
HX531, which contains a dibenzodiazepine skeleton, is one of the first retinoid X receptor (RXR) antagonists. Functioning via RXR-PPARγ heterodimer,...
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Characterization of crude ovomucins obtained from various egg white layers
Structurally, egg white (EW) is composed of four distinct layers: outer thin white, thick white, inner thin white and chalaziferous layer (including...
