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A visual on-site biosensor for low-cost detection of chloramphenicol based on aptamer and split DNAzyme
AbstractChloramphenicol (CAP) is a kind of broad-spectrum antibiotic, which has been forbidden in food by most countries because of its side effects....
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Dual DNAzyme-catalytic assembly of G-quadruplexes for inducing the aggregation of gold nanoparticles and develo** a novel antibiotic assay method
By utilizing a target biorecognition reaction to induce the self-assembly of G-quadruplexes and the aggregation of gold nanoparticles (Au NPs), this...
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A low-noise ratiometric fluorescence biosensor for detection of Pb2+ based on DNAzyme and exonuclease III–assisted cascade signal amplification
As a common heavy metal ion with strong toxicity and wide distribution, lead ions (Pb 2+ ) had great harm to the human body. In this work, a low-noise...
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Development of a DNAzyme-based colorimetric biosensor assay for dual detection of Cd2+ and Hg2+
A colorimetric biosensor assay has been developed for Cd 2+ and Hg 2+ detection based on Cd 2+ -dependent DNAzyme cleavage and Hg 2+ -binding-induced...
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Label-free DNAzyme for highly sensitive detection of multiple biomolecules in real samples through target-triggered catalytic cleavage reactions with auramine O’s discriminated fluorescence emission
A universal enzyme strand (E-DNA) recyclable L-histidine (L-His), melamine (MA), and cisplatin (CP) biosensor was fabricated on the basis of a...
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The recent advancements in the early detection of cancer biomarkers by DNAzyme-assisted aptasensors
AbstractClinical diagnostics rely heavily on the detection and quantification of cancer biomarkers. The rapid detection of cancer-specific biomarkers...
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Target-swiped DNA lock for electrochemical sensing of miRNAs based on DNAzyme-assisted primer-generation amplification
As an extremely important post-transcriptional regulator, miRNAs are involved in a variety of crucial biological processes, and the abnormal...
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Sensitive colorimetric detection of miRNA-155 via G-quadruplex DNAzyme decorated spherical nucleic acid
Rapid and sensitive detection of biomarkers enables monitoring patients’ health status and can enhance the early diagnosis of deadly diseases. In...
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A biologically stable DNAzyme that efficiently silences gene expression in cells
Efforts to use RNA-cleaving DNA enzymes (DNAzymes) as gene-silencing agents in therapeutic applications have stalled due to their low efficacy in...
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Washing-free Electrochemical Strategy to Detect Target DNA Utilizing Peroxidase Mimicking DNAzyme
We herein describe a novel washing-free electrochemical strategy for target DNA detection by utilizing the peroxidase mimicking DNAzyme. The...
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DNAzyme-powered DNA walking machine for ultrasensitive fluorescence aptasensing of kanamycin
A DNAzyme-powered DNA walking machine was constructed to develop the fluorescence aptasensing for sensitive detection of kanamycin. The aptamer for...
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Portable, quantitative, and sequential monitoring of copper ions and pyrophosphate based on a DNAzyme-Fe3O4 nanosystem and glucometer readout
In this report, portable, quantitative, and sequential monitoring of copper ions and pyrophosphate (PPi) with a single sensor based on a DNAzyme-Fe 3 O 4 ...
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Environmental and intercellular Pb2+ ions determination based on encapsulated DNAzyme in nanoscale metal-organic frameworks
With the merits of low cost, simple synthesis procedure, and high affinity for metal ions, deoxyribozyme (DNAzyme) have played important roles in...
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Structure of a 10-23 deoxyribozyme exhibiting a homodimer conformation
Deoxyribozymes (DNAzymes) are in vitro evolved DNA sequences capable of catalyzing chemical reactions. The RNA-cleaving 10-23 DNAzyme was the first...
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DNAzyme-Au nanoprobe coupled with graphene-oxide–loaded hybridization chain reaction signal amplification for fluorometric determination of alkaline phosphatase
A sensing platform is presented for the determination of alkaline phosphatase (ALP) activity based on the cooperation of DNAzyme-Au spherical nucleic...
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A Novel DNAzyme Signal Amplification-based Colorimetric Method for RNase H Assays
A simple visual strategy was developed for the RNase H colorimetric measurement using DNAzyme-mediated signal amplification. When RNase H was...
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A simple and label-free proximity-catalytic hairpin reaction-based method for sensitive and miRNA analysis
Aberrant expression of microRNAs (miRNAs) has been shown to be linked to several crucial biological processes, including as carcinogenesis,...
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A label-free lead(II) ion sensor based on surface plasmon resonance and DNAzyme-gold nanoparticle conjugates
Detection of lead(II) (Pb 2+ ) ions in water is important for the protection of human health and environment. The growing demand for onsite detection...
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A highly sensitive DNAzyme-based SERS biosensor for quantitative detection of lead ions in human serum
Lead ions (Pb 2+ ), one form of the toxic heavy metal, have drawn significant attention due to their harmful effects on human health and the...
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Advancing XNAzymes as Nucleic Acid Therapeutics
DNA enzymes (DNAzymes) with site-specific RNA cleavage activity hold great promise as gene silencing agents, but more work is needed for these...