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Engineered cytochrome P450 for direct arylalkene-to-ketone oxidation via highly reactive carbocation intermediates
Ketones are crucial intermediates in synthesis and frequent moieties in many products. The direct regioselective synthesis of ketones from internal...
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Architecture of the membrane-bound cytochrome c heme lyase CcmF
The covalent attachment of one or multiple heme cofactors to cytochrome c protein chains enables cytochrome c proteins to be used in electron...
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Quench treatment cytochrome c: Transformation from a classical redox protein to a peroxidase like enzyme
Hemoproteins play important roles in physiological activities in animals and plants. The research on the structures and properties of hemoproteins...
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Enhanced Substrate Specificity of Thermostable Cytochrome P450 CYP175A1 by Site Saturation Mutation on Tyrosine 68
Thermostable cytochrome P450 (CYP175A1) cloned from Thermus thermophilus shows mid-point unfolding temperature (Tm) of 88 °C (361 K) along with high...
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N-terminal epitope surface imprinted particles for high selective cytochrome c recognition prepared by reversible addition- fragmentation chain transfer strategy
A kind of surface imprinted particles was synthesized to recognize cytochrome c (Cyt c) by a novel strategy combining reversible...
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Splice Variants of mRNA of Cytochrome P450 Genes: Analysis by the Nanopore Sequencing Method in Human Liver Tissue and HepG2 Cell Line
AbstractThe analysis of cytochrome P450 transcripts was carried out by the nanopore sequencing in liver tissue samples of three donors and HepG2 line...
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Selective steroidogenic cytochrome P450 haem iron ligation by steroid-derived isonitriles
Alkyl isonitriles, R—NC, have previously been shown to ligate the heme (haem) iron of cytochromes P450 in both accessible oxidation states (ferrous,...
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A cytochrome c is the natural electron acceptor for nicotine oxidoreductase
Nicotine oxidoreductase (NicA2), a member of the flavin-containing amine oxidase family, is of medical relevance as it shows potential as a...
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Interaction of Abiraterone and Its Pharmacologically Active Metabolite D4A with Cytochrome P450 2C9 (CYP2C9)
AbstractWe studied the interaction of the antitumor agent abiraterone and its pharmacologically active metabolite D4A, which is promising for use as...
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Biocatalytic, enantioenriched primary amination of tertiary C–H bonds
Intermolecular functionalization of tertiary C–H bonds to construct fully substituted stereogenic carbon centres represents a formidable challenge:...
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Design of a redox-proficient Escherichia coli for screening terpenoids and modifying cytochrome P450s
High-value terpenoids are found in plants, animals and microbes, with applications spanning health to agriculture. However, moving their biosynthetic...
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Systematic engineering pinpoints a versatile strategy for the expression of functional cytochrome P450 enzymes in Escherichia coli cell factories
Production of plant secondary metabolites in engineered microorganisms provides a scalable and sustainable alternative to their sourcing from nature...
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Cytochrome c/Multi-walled Carbon Nanotubes Modified Glassy Carbon Electrode for the Detection of Streptomycin in Pharmaceutical Samples
A novel electrochemical glassy carbon electrode modified with a multi-walled carbon nanotube, cytochrome c (Cyt c ) and zinc oxide nanoparticles...
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Species-specific markers for Nilaparvata lugens and Sogatella furcifera (Hemiptera: Delphacidae) based on mitochondrial cytochrome oxidase I
Brown planthopper (BPH), Nilaparvata lugens (Stål) and white-backed planthopper (WBPH), Sogatella furcifera (Horváth) are the most destructive...
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Nitrogen-doped carbon quantum dots fabricated from cellulolytic enzyme lignin and its application to the determination of cytochrome c and trypsin
A sensitive and effective strategy for the detection of cytochrome c (Cyt c) and trypsin was developed using biomass nitrogen-doped carbon quantum...
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Effect of confinement of horse heart cytochrome c and formate dehydrogenase from Candida boidinii on mesoporous carbons on their catalytic activity
This study reports the immobilization of two biocatalysts (e.g., cytochrome c—Cyt c—and the non-metalloenzyme formate dehydrogenase from Candida...
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Association Study of Transforming Growth Factor Beta 1 + 29 T/C exon 1 Polymorphism in Breast Cancer Patients from North Indian Population
Background: TGFB1 cytokine is involved in normal mammary epithelial development as well as in breast tumorigenesis. It has role in both breast tumor...
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Modeling the hydroxylation of estragole via human liver cytochrome P450
Natural compounds derived from plants are generally regarded safe and devoid of adverse effects. However, there are individual ingredients that...
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DNA controllable peroxidase-like activity of Ti3C2 nanosheets for colorimetric detection of microcystin-LR
The peroxidase-like activity of Ti 3 C 2 nanosheets (Ti 3 C 2 NSs) was evaluated by catalytic oxidation of colorless o-phenylenediamine (OPD) into...
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Synergistic Catalysis of Enzymes and Biomimetic MOFs: Immobilizing Cyt c on Two-dimensional MOFs to Enhance the Performance of Peroxidase
Metal-organic frameworks(MOFs) have been widely regarded as promising carriers for enzyme immobilization owing to their advantages in improving...
