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N-glycoside synthesis through combined copper- and photoredox-catalysed N-glycosylation of N-nucleophiles
State-of-the-art glycosylation methods primarily rely on ionic reactions of heteroatomic nucleophiles with electrophilic glycosyl oxocarbenium...
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Competition of (3+2) annulation and (3+2) cycloaddition in the reaction of alkenes with donor-acceptor cyclopropanes
Lewis acid-initiated reaction of (het)aryl-substituted donor-acceptor cyclopropanes with styrenes was studied. The initiation of the process by tin( IV ...
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Silver/chiral pyrrolidinopyridine relay catalytic cycloisomerization/(2 + 3) cycloadditions of enynamides to asymmetrically synthesize bispirocyclopentenes as PDE1B inhibitors
Significant progress has been made in asymmetric synthesis through the use of transition metal catalysts combined with Lewis bases. However, the use...
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Enantioselective synthesis of atropisomeric indoles via iron-catalysed oxidative cross-coupling
Heterobiaryl compounds that exhibit axial chirality are of increasing value and interest across several fields, but direct oxidative methods for...
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Oxidative Cross-Coupling of Cysteamine with Secondary Phosphine Chalcogenides: Aspects of Reaction Chemoselectivity
AbstractCysteamine (2-aminoethanethiol) undergoes oxidative cross-coupling with secondary phosphine sulfides and phosphine selenides under mild...
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Chemodivergent C(sp3)–H and C(sp2)–H cyanomethylation using engineered carbene transferases
The ubiquity of C–H bonds presents an opportunity to efficiently elaborate and build complexity in organic molecules. Methods for selective...
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Ni-catalysed assembly of axially chiral alkenes from alkynyl tetracoordinate borons via 1,3-metallate shift
Asymmetric synthesis based on a metallate shift of tetracoordinate borons is an intriguing and challenging topic. Despite the construction of central...
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Programmable late-stage functionalization of bridge-substituted bicyclo[1.1.1]pentane bis-boronates
Modular functionalization enables versatile exploration of chemical space and has been broadly applied in structure–activity relationship (SAR)...
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Metalloradical approach for concurrent control in intermolecular radical allylic C−H amination
Although they offer great potentials, the high reactivity and diverse pathways of radical chemistry pose difficult problems for applications in...
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Photochemical diversification of strong C(sp3)–H bonds enabled by allyl bromide and sodium fluoride
The development of practical approaches for the selective functionalization of strong, neutral C( sp 3 )–H bonds, such as those in petroleum-derived...
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Regioselective access to polycyclic N-heterocycles via homogeneous copper-catalyzed cascade cyclization of allenynes
Polycyclic N-heterocycles are important structural motifs commonly found in bioactive compounds, however, their selective construction via the...
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A boryl-migratory semipinacol rearrangement
The semipinacol rearrangement is one of the classic yet useful synthetic tools in organic synthesis. However, semipinacol rearrangements involving...
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Specific cross-dimerization of terminal alkynes via Pd/TMEDA catalysis
The cross-dimerization of terminal alkynes is the most straightforward and attractive approach to differently substituted 1,3-enynes, which are vital...
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Mechanistic Study of Organocatalytic Chemoselective Monoacylation of 1,5-Pentanediol
Fine molecular transformation is one of the fundamental challenges in organic synthesis. Kawabata and co-workers have developed various acylative...
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Rhodium-catalyzed enantio- and diastereoselective carboamidation of bicyclic olefins toward construction of remote chiral centers and axis
The precise control of multiple chiral elements through a single step catalytic process remains a significant challenge in asymmetric catalysis....
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Radical thioesterification via nickel-catalysed sensitized electron transfer
Multi-catalytic reaction modes have attracted widespread attention in synthetic chemistry. The merger of nickel catalysis with photoredox catalysis...
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Nanocrystals perovskites photocatalyzed singlet oxygen generation for light-driven organic reactions
Lead halide perovskite nanocrystals were prepared and used as photocatalysts for the in situ 1 O 2 generation to perform hetero Diels–Alder, ene and...
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A molecular electron density theory investigation of the molecular mechanism, regioselectivity, stereoselectivity and chemoselectivity of cycloaddition reaction between acetonitrile N-oxide and 2,5-dimethyl-2H-[1,2,3]diazarsole
The cycloaddition reactions (32CA) of acetonitrile N-oxide and 2,5-dimethyl-2H-[1,2,3]diazarsole 1 have been examined employing the molecular...
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Synthesis, X-ray structure, DFT investigation, and molecular docking of 1,3,5-tricyclohexyl-1,3,5-triazinane-2,4,6-trione, a cyclic polyamide with anti HIV-1 (RT), antiplatelet, and anticoagulant activities
1,3,5-tricyclohexyl-1,3,5-triazinane-2,4,6-trione ( TCy-TAZTO ) was obtained with high chemoselectivity and excellent yield, through an efficient and...
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Catalytic reductive desymmetrization of malonic esters
Desymmetrization of fully substituted carbons with a pair of enantiotopic functional groups is a practical strategy for the synthesis of quaternary...
