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An UHPLC-QE-Orbitrap-MS Method for Accurate Quantification of Short-Chain Fatty Acids in Serum From an Older Chinese Population
Short-chain fatty acids (SCFAs), such as acetic acid, propionic acid, lactic acid, β-hydroxybutyric acid, and crotonic acid, play key biological...
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A Method to Externally Adjust the Column Length in Gas Chromatography Using a Water Stationary Phase
A novel method for externally adjusting the column length during gas chromatography (GC) operation is introduced. The technique employs the...
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Determination of New 4-Aryl-pyrido[1,2-c]pyrimidine Derivatives, Potential Antidepressant Agents with a High Affinity to 5-Hydroxytryptamin 1A Receptor and Serotonin Transporter Protein Receptor, with Capillary Electrophoresis
A novel capillary electrophoresis method was developed for the determination of new 4-aryl-pyrido[1,2-c]pyrimidine derivatives, potential...
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A Certified Reference Material of Polyvinyl Chloride Containing Phthalic Esters (NMIJ CRM 8156-a) for Screening Device Applications
Phthalic esters (PEs) are used as plasticizers for plastic products especially for polyvinyl chloride (PVC). Owing to their adverse effects on human...
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Analysis of Coumarin-Based Phototoxins in Citrus-Derived Essential Oils Using Liquid Chromatography-Mass Spectrometry
The occurrence of coumarin-based photoactive compounds in essential oils has been a concern due to the adverse health effects it has on human health....
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Chemical Composition Analysis and Multi-index Component Content Determination of Compounds in Goupi Plaster Based on UPLC–Q-Exactive-MS and UPLC–MS/MS
ObjectiveThis study sought to evaluate and validate a method for chemical composition analysis and content determination of Goupi plaster components,...
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Forced Degradation of an Anticancer Drug Apalutamide: Impurity Profiling and Structure Elucidation Study
An anticancer drug apalutamide approved by United States Food and Drug Administration in 2018 is one of the most commonly prescribed chemotherapeutic...
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Comparative Study of Cellulose Tris(3-chloro-5-methylphenylcarbamate) Coated or Covalently Immobilized on Silica for the Separation of Enantiomers in High-Performance Liquid Chromatography
In the present study, a comparison was performed between chiral stationary phases (CSPs) prepared by coating or covalent immobilization of cellulose...
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HPLC Retention Behavior of Oligonucleotides on an Anion-Exchange HPLC with a High Concentration of Urea
Roles of short RNA molecules in the emergence process of primitive life-like system and physiological activities have been extensively studied from...
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Support Vector Models-Based Quantitative Structure–Retention Relationship (QSRR) in the Development and Validation of RP-HPLC Method for Multi-component Analysis of Anti-diabetic Drugs
This work emphasized the use of the quantitative structure–retention relationship (QSRR) approach in the prediction retention time of anti-diabetic...
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Pharmacokinetic, Protein Binding, and Tissue Distribution Investigations of Viloxazine Enantiomers in Rat Plasma by HPLC–MS/MS Using Polysaccharide-Based Immobilized Chiral Column: A Preclinical Approach to Possible Chiral Switch
Viloxazine has a long past of medical use to treat depression in Europe, and it has lately been repurposed for the treatment of...
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DoE Guided Development of an HPLC Method for Evaluation of Amoxicillin and Metronidazole Co-loaded Mucoadhesive GRDDS Formulation for H. pylori Eradication
H. Pylori infection is a major reason for chronic Peptic Ulcer Disease (PUD) and related complications worldwide. Traditional treatment options fail...
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Tandem-Column High Performance Liquid Chromatography Separation of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
A tandem-column liquid chromatographic method was developed to separate ten non-steroidal anti-inflammatory drugs (Aceclofenac, Aspirin, Carprofen,...
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Rapid Simultaneous Determination of Cyanide, Azide, and Ethanol in Whole Blood Using Headspace Gas Chromatography-Mass Spectrometry
The rapid detection and quantification of toxic substances and alcohol in biological specimens stand as imperative tasks, particularly in instances...
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Quality Evaluation of Sanguisorbae Radix via Python Aided Optimization Fingerprint Chromatography Combined with Quantitative Analysis of Multi-components by Single Marker
A simple method was proposed to assess the quality of Sanguisorbae Radix based on Python-aided optimization fingerprint chromatography (FC) combined...
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Glycerol-Based Green RP-HPLC Method for Simultaneous Determination of Methionine and Paracetamol in Pharmaceutical Tablets
Methionine and paracetamol are combined in dosage forms due to the ability of methionine to compensate the deficiency in glutathione in hepatic...
