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Sonodynamic and sonomechanical effect on cellular stemness and extracellular physicochemical environment to potentiate chemotherapy
BackgroundHypoxia-activated prodrug (HAP) is a promising candidate for highly tumor-specific chemotherapy. However, the oxygenation heterogeneity and...
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A new direction in periodontitis treatment: biomaterial-mediated macrophage immunotherapy
Periodontitis is a chronic inflammation caused by a bacterial infection and is intimately associated with an overactive immune response. Biomaterials...
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Proangiogenic effect and underlying mechanism of holmium oxide nanoparticles: a new biomaterial for tissue engineering
BackgroundEarly angiogenesis provides nutrient supply for bone tissue repair, and insufficient angiogenesis will lead tissue engineering failure....
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NIR-responsive CN-Pt-GEM hydrogel induces necroptosis and immunotherapeutic responses prevent postoperative recurrence and wound infection in lung carcinoma
BackgroundCancer recurrence following surgical resection is a major cause of treatment failure. Finding effective methods to prevent postoperative...
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Laser-activated perfluorocarbon nanodroplets for intracerebral delivery and imaging via blood–brain barrier opening and contrast-enhanced imaging
BackgroundUltrasound and photoacoustic (US/PA) imaging is a promising tool for in vivo visualization and assessment of drug delivery. However, the...
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Calculating transmembrane voltage on the electric pulse-affected cancerous cell membrane: using molecular dynamics and finite element simulations
ContextElectroporation is a technique that creates electrically generated pores in the cell membrane by modifying transmembrane potential. In this...
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Dual-loaded nano pesticide system based on industrial grade scaleable carrier materials with combinatory efficacy and improved safety
Repeated and widespread use of single chemical pesticides raises concerns about efficiency and safety, develo** multi-component synergistic...
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Multifunctional nano-in-micro delivery systems for targeted therapy in fundus neovascularization diseases
Fundus neovascularization diseases are a series of blinding eye diseases that seriously impair vision worldwide. Currently, the means of treating...
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Injectable hybrid hydrogels enable enhanced combination chemotherapy and roused anti-tumor immunity in the synergistic treatment of pancreatic ductal adenocarcinoma
Chemotherapy and immunotherapy have shown no significant outcome for unresectable pancreatic ductal adenocarcinoma (PDAC). Multi-drug combination...
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Electroactive Brevundimonas diminuta consortium mediated selenite bioreduction, biogenesis of selenium nanoparticles and bio-electricity generation
In this study, highly selenite-resistant strains belonging to Brevundimonas diminuta (OK287021, OK287022) genus were isolated from previously...
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Microsolvation of cobalt, nickel, and copper atoms with ammonia: a theoretical study of the solvated electron precursors
ContextThe s-block metals dissolved in ammonia form metal–ammonia complexes with diffuse electrons which could be used for redox catalysis. In this...
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Combined SERS-Raman screening of HER2-overexpressing or silenced breast cancer cell lines
BackgroundBreast cancer (BC) is a heterogeneous neoplasm characterized by several subtypes. One of the most aggressive with high metastasis rates...
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Repair spinal cord injury with a versatile anti-oxidant and neural regenerative nanoplatform
Spinal cord injury (SCI) often results in motor and sensory deficits, or even paralysis. Due to the role of the cascade reaction, the effect of...
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Advancing fluorescence imaging: enhanced control of cyanine dye-doped silica nanoparticles
BackgroundSilica nanoparticles (SNPs) have immense potential in biomedical research, particularly in drug delivery and imaging applications, owing to...
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Cartilage progenitor cells derived extracellular vesicles-based cell-free strategy for osteoarthritis treatment by efficient inflammation inhibition and extracellular matrix homeostasis restoration
Osteoarthritis (OA) is a common degenerative joint disease which currently lacks of effective agents. It is therefore urgent and necessary to seek an...
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Tumor microenvironment responsive nano-herb and CRISPR delivery system for synergistic chemotherapy and immunotherapy
Chemoresistance remains a significant challenge for effective breast cancer treatment which leads to cancer recurrence. CRISPR-directed gene editing...
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Photosensitive and dual-targeted chromium nanoparticle delivering small interfering RNA YTHDF1 for molecular-targeted immunotherapy in liver cancer
Tumor-associated macrophages (TAMs) are a promising target for cancer immunotherapy, but delivering therapeutic agents to TAMs within the tumor...
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Diffusion of curcumin in PLGA-based carriers for drug delivery: a molecular dynamics study
Context:The rapid growth and diversification of drug delivery systems have been significantly supported by advancements in micro- and...
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Single-cell RNA transcriptomic reveal the mechanism of MSC derived small extracellular vesicles against DKD fibrosis
Diabetic kidney disease (DKD), a chronic kidney disease, is characterized by progressive fibrosis caused due to persistent hyperglycemia. The...
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Exosomes as drug delivery systems in glioma immunotherapy
Recently, the significant benefits of cancer immunotherapy for most cancers have been demonstrated in clinical and preclinical studies. However, the...
