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DoE-Aided Optimization of RP-HPLC Method for Simultaneous Estimation of Amoxicillin and Tinidazole Loaded Mucoadhesive GRDDS Formulation for the Treatment of H. pylori
Helicobacter pylori (H. pylori) infection is one of the primary risk factors of peptic ulcer disease worldwide. Treatment of H. pylori with the...
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Identification of acetylcholinesterase inhibitory metabolites from hydroalcoholic extract of Itrifal Muqawwi Dimagh using thin-layer chromatography‒bioautography‒mass spectroscopy and its validation using in silico molecular approach
Traditional formulations owing to their holistic approach to health and wellness with minimum side effects are widely used all over the globe. Itrifal...
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A Novel Enantioselective Chitosan-Based Stationary Phase Prepared by Molecular Imprinting of a Racemic Template
Chitosan is a chiral polyglucosamine polysaccharide that selectively binds to S -enantiomer of ketorolac rather than R -enantiomer. In this paper, a...
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Simultaneous Determination of Ethyleneamines by Reversed-Phase Ion-Pair Chromatography with Ultraviolet Detection Using on-Line Complexation with Copper(II) Ion
A selective and simple method was developed for the determination of four ethyleneamines (EAs), i.e., ethylenediamine (EDA), diethylenetriamine...
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On the Focusing Mechanism in Thermal Field-Flow Fractionation of Macromolecules
The potential of separation of the macromolecules in solution by focusing thermal field-flow fractionation is critically analyzed. The experimental...
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Evaluation and observance of variation in chemical and antioxidant activity changes during the development of fenugreek seeds following thin-layer chromatography–fingerprint and marker analysis
Fenugreek seeds are integral to Indian cuisine and have been used as traditional medicine since antiquity. A variety of chemical constituents are...
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Comprehensive Quantification of Miconazole Nitrate, Mupirocin, and Mometasone Furoate: a Dual Analysis via HPLC and HPTLC with Comparative Evaluation Against Greenness Parameters
Combination treatment enhances efficacy, minimizes side effects, and improves convenience for patients with diverse treatment schedules. This...
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Simultaneous determination of amlodipine besylate and azilsartan mixture in human plasma utilizing high-performance thin-layer chromatography with ultraviolet detection
A novel, efficient, and sensitive high-performance thin-layer chromatography (HPTLC) method has been developed and validated for the concurrent...
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Validation and Application of a Dried Blood Spot Amoxicillin Assay
Dried blood spot (DBS) antibiotic assays can facilitate pharmacokinetic (PK) investigations in situations where venous blood sampling is logistically...
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Tyrosine-Phosphorylated Peptide Imprinted Particles Prepared by Reversible Addition–Fragmentation Chain Transfer Polymerization and “Epitope” Strategy: Selective Recognition of Phosphorylated Angiotensin II
Phosphorylation is one of the most common post-translational modifications of proteins. Recognition of phosphorylated peptides with high selectivity...
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Quantitative Estimation of 10 Known Impurities from Indacaterol Acetate, Glycopyrronium, and Mometasone Furoate Dry Powder Inhalation Product
Indacaterol, glycopyrronium, and mometasone furoate triple combination inhalable fixed-dose medicines are effectively used to treat asthma and...
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A Stable and Sensitive TLC-Spray for Thiols, Disulfides and Thioesters
A sensitive and stable spray for thin layer chromatography of acyl-CoA and other thio-compounds has been evaluated. CoA, down to 1 nmol, is readily...
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Filtration Analysis of Microparticles Using Paper-Based Microfluidics
A virus is a sub-microscopic infectious organism that causes diseases in humans, animals, and plants resulting in morbidity and may cause mortality....
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Reversed-phase thin-layer chromatography and ultra-performance liquid chromatography/mass spectrometry to estimate the drug likeness of phosphodiesterase 10A inhibitors with phthalimide core
Lipophilicity is a physicochemical parameter well known as a decisive factor for predicting the successful development of a drug. Thus, a balance...
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Integration of Magnetic Dispersive Solid-Phase Micro-extraction with HPLC for Precise Detection of Tumor Markers 1-Methyladenosine and 1-Methylinosine in Urine Samples from Breast Cancer Patients
To analyze 1-methyladenosine (m1A) and 1-methylinosine (m1I) in urine samples obtained from patients with breast cancer and healthy people, we used...
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Measurement of Serum Vitamins B2 and B6 in Patients with Hashimoto’s Thyroiditis by LC–MS/MS Method
Vitamin B2 and vitamin B6 are cofactors and coenzymes in many biochemical reactions, and their sufficient serum concentrations may be crucial for the...
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Simultaneous estimation of lupeol, stigmasterol and betulin in Desmodium oojeinensis bark and roots by a validated instrumental thin-layer chromatography method
Desmodium oojeinensis (Roxb.) H. Ohashi (DO) plant has been traditionally known to possess astringent, anti-inflammatory, hepatoprotective, wound...
