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SERS and electrochemical dual-mode detection of miRNA-141 by using single Au@Ag nanowire as a new platform
As biomarkers of cancer, the accurate and sensitive detection of microRNAs is of great significance. Therefore, we proposed a surface-enhanced Raman...
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Binding studies of promethazine and its metabolites with human serum albumin by high-performance affinity chromatography and molecular docking in the presence of codeine
“Purple Drank”, a soft drink containing promethazine (PMZ) and codeine (COD), has gained global popularity for its hallucinogenic effects. Consuming...
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Identification and Semi-quantification of 36 Compounds from Violae herba (Zihuadiding) via UHPLC-Q-Orbitrap-MS/MS as Well as Proposal of Anti-counterfeiting Quality-Marker for Pharmacopeia
Violae herba (Zihuadiding) is a common Chinese herbal medicine. The current Chinese Pharmacopeia (ChP) defines Viola yedoensis Makino as the sole...
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Colorimetric enzymatic rapid test for the determination of atropine in baby food using a smartphone
A method for the enzymatic determination of atropine has been developed, which is based on a sequence of reactions involving (1) the hydrolysis of...
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Subzero project: comparing trace element profiles of enriched mitochondria fractions from frozen and fresh liver tissue
From organs to subcellular organelles, trace element (TE) homeostasis is fundamental for many physiological processes. While often overlooked in...
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Soft ionization mechanisms in flexible µ-tube plasma—from FµTP to closed µ-tube plasma
In order to find an explanation for the mechanism in a plasma operated with an alternating voltage, or rather a square wave voltage, such a plasma...
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15N metabolic labeling-TMT multiplexing approach to facilitate the quantitation of glycopeptides derived from cell lines
The study of glycoproteomics presents a set of unique challenges, primarily due to the low abundance of glycopeptides and their intricate...
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Experimental design optimisation and validation by accuracy profile of a novel method for Hg speciation analysis by HPLC-ICP-MS and application to Total Diet Studies
This study addresses the development and validation of an analytical method for speciation analysis of mercury (inorganic/Hg 2+ and methylmercury/CH 3 Hg
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Evaluation and clinical application of a bracketing calibration-based isotope dilution liquid chromatography-tandem mass spectrometry candidate reference measurement procedure for serum theophylline
A candidate reference measurement procedure (RMP) for serum theophylline via isotope dilution liquid chromatography-tandem mass spectrometry...
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DoE-Aided Optimization of RP-HPLC Method for Simultaneous Estimation of Amoxicillin and Tinidazole Loaded Mucoadhesive GRDDS Formulation for the Treatment of H. pylori
Helicobacter pylori (H. pylori) infection is one of the primary risk factors of peptic ulcer disease worldwide. Treatment of H. pylori with the...
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Sensitive detection of uric acid based on low-triggering-potential cathodic luminol electrochemiluminescence achieved by ReS2 nanosheets
The majority of previously reported cathodic electrochemiluminescence (ECL) systems often required very negative potential to be carried out, which...
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A novel AIE-based mitochondria-targeting fluorescent probe for monitoring of the fluctuation of endogenous hypochlorous acid in ferroptosis models
Ferroptosis is a way of cell death mainly due to the imbalance between the production and degradation of lipid reactive oxygen species, which is...
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Development and evaluation of a candidate reference measurement procedure for detecting 17α-hydroxyprogesterone in dried blood spots using isotope dilution liquid chromatography tandem mass spectrometry
17α-Hydroxyprogesterone (17α-OHP) quantification in dried blood spots (DBS) is essential for newborn screening for congenital adrenal hyperplasia...
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A new HPLC method with multiple detection systems for impurity analysis and discrimination of natural versus synthetic cannabidiol
Cannabidiol (CBD) is the main non-psychoactive phytocannabinoid derived from Cannabis sativa L. It is now an active pharmaceutical ingredient (API),...
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Iridium(III) solvent complex–based electrogenerated chemiluminescence method for the detection of 3-methylhistidine in urine
3-Methylhistidine (3-MeHis) is increasingly used as an indicator of muscle protein breakdown. The development of a sensitive, simple, and...
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Characterization of biotinylated human ACE2 and SARS-CoV-2 Omicron BA.4/5 spike protein reference materials
Accurate diagnostic and serology assays are required for the continued management of the COVID-19 pandemic yet spike protein mutations and...
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Cohort-based strategies as an in-house tool to evaluate and improve phenoty** robustness of LC–MS/MS lipidomics platforms
In recent years, instrumental improvements have enabled the spread of mass spectrometry–based lipidomics platforms in biomedical research. In mass...
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Scaling up a targeted exposome LC-MS/MS biomonitoring method by incorporating veterinary drugs and pesticides
Humans are exposed to a cocktail of food-related and environmental contaminants, potentially contributing to the etiology of chronic diseases. Better...
