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Forty years of advances in optical biosensors—are “autonomous” biosensors in our future?
Optical biosensors have employed at least three distinct system architectures over the last 40 years, moving from “sample in-answer out” systems to...
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Eco-friendly optical sensor for precise detection of gold ions in diverse matrices through the integration of β-2-hydroxybenzyl-3-methoxy-2-hydroxyazastyrene in a PVC membrane
An environmentally conscious methodology is investigated for the precise and discerning identification of trace concentrations of gold ions in...
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Comparison of data processing strategies using commercial vs. open-source software in GC-Orbitrap-HRMS untargeted metabolomics analysis for food authentication: thyme geographical differentiation and marker identification as a case study
Untargeted analysis of gas chromatography–high-resolution mass spectrometry (GC-HRMS) data is a key and time-consuming challenge for identifying...
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Real-time monitoring of intracellular biochemical response in locally stretched single cell by a nanosensor
Mechanotransduction is the essential process that cells convert mechanical force into biochemical responses, and electrochemical sensor stands out...
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Precise measurement of Fe isotopes in marine and biological samples by pseudo-high-resolution multi-collector inductively coupled plasma mass spectrometry (MC-ICPMS)
This paper introduces an enhanced technique for analyzing iron isotopes in complex marine and biological samples. A dedicated iron purification...
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Selective dual sensing strategy for free and vitamin D3 micelles in food samples based on S,N-GQDs photoinduced electron transfer
A reliable nanotechnological sensing strategy, based on an S,N-co-doped graphene quantum dot (GQD) platform, has been developed to distinctly detect...
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Simultaneous quantification of terpenes and cannabinoids by reversed-phase LC-APCI-MS/MS in Cannabis sativa L. samples combined with a subsequent chemometric analysis
Cannabis sativa L . has been the most discussed medicinal plant in recent years. In particular, the dynamic shift from a formerly illicit and tightly...
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Analytical control of imatinib in bioanalytical samples using graphene quantum dots sensing
An analytical method for the determination of imatinib (IMA, the primary treatment for chronic myeloid leukemia), based on the fluorescence...
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Transition-metal-based nanozymes for biosensing and catalytic tumor therapy
Nanozymes, as an emerging class of enzyme mimics, have attracted much attention due to their adjustable catalytic activity, low cost, easy...
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Development of a nine-variant reference material panel to standardize cell-free DNA detection
Detection of specific gene mutations in cell-free DNA (cfDNA) serves as a valuable cancer biomarker and is increasingly being explored as an...
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Single-step batch fabrication of microfluidic paper-based analytical devices with a 3D printer and their applications in nanoenzyme-enhanced visual detection of dopamine
Wax printing is the most widely used method for fabricating microfluidic paper-based analytical devices (μPADs), but it still suffers from...
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DESI-MSI-guided exploration of metabolic-phenotypic relationships reveals a correlation between PI 38:3 and proliferating cells in clear cell renal cell carcinoma via single-section co-registration of multimodal imaging
A workflow has been evaluated that utilizes a single tissue section to obtain spatially co-registered, molecular, and phenotypical information...
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Non-targeted mass spectrometry and feature-based molecular networking for determination of branched fatty acid esters of hydroxy fatty acids in milk
Branched fatty acid esters of hydroxy fatty acids (FAHFAs) represent trace lipids with significant natural biological functions. While exogenous...
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Multiplexed in situ RNA imaging by combFISH
Multiplexed in situ RNA imaging offers new opportunities for gene expression profiling by providing high-throughput spatial information. In this...
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A new simplified sequence-dependent loop-mediated isothermal amplification (LAMP) detection method
Fluorescence dye-based loop-mediated isothermal amplification (LAMP) is a sensitive nucleic acid detection method, but is limited to single-plex...
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Nanosilver-based materials as feed additives: Evaluation of their transformations along in vitro gastrointestinal digestion in pigs and chickens by using an ICP-MS based analytical platform
The use of a new nanomaterial in the feed chain requires a risk assessment that involves in vitro gastrointestinal digestions to predict its...
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Comprehensive Quantification of Miconazole Nitrate, Mupirocin, and Mometasone Furoate: a Dual Analysis via HPLC and HPTLC with Comparative Evaluation Against Greenness Parameters
Combination treatment enhances efficacy, minimizes side effects, and improves convenience for patients with diverse treatment schedules. This...
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Simultaneous determination of amlodipine besylate and azilsartan mixture in human plasma utilizing high-performance thin-layer chromatography with ultraviolet detection
A novel, efficient, and sensitive high-performance thin-layer chromatography (HPTLC) method has been developed and validated for the concurrent...
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Unconventional approaches for chiral resolution
Chirality is a fundamental and ubiquitous property of nature involved in multiple fields of science. In particular, the possible resolution of the...
