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Recombinant human enamelin produced in Escherichia coli promotes mineralization in vitro
BackgroundEnamelin is an enamel matrix protein that plays an essential role in the formation of enamel, the most mineralized tissue in the human...
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Antibacterial and antibiofilm potentials of vancomycin-loaded niosomal drug delivery system against methicillin-resistant Staphylococcus aureus (MRSA) infections
The threat of methicillin-resistant Staphylococcus aureus (MRSA) is increasing worldwide, making it significantly necessary to discover a novel way...
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Optimisation of indole acetic acid production by Neopestalotiopsis aotearoa endophyte isolated from Thymus vulgaris and its impact on seed germination of Ocimum basilicum
BackgroundMicrobial growth during plant tissue culture is a common problem that causes significant losses in the plant micro-propagation system. Most...
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Design of a novel multi-epitope vaccine against Marburg virus using immunoinformatics studies
Marburg virus (MARV) is a highly contagious and virulent agent belonging to Filoviridae family. MARV causes severe hemorrhagic fever in humans and...
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Increased stable integration efficiency in CHO cells through enhanced nuclear localization of Bxb1 serine integrase
BackgroundMammalian display is an appealing technology for therapeutic antibody development. Despite the advantages of mammalian display, such as...
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Screening of Candida spp. in wastewater in Brazil during COVID-19 pandemic: workflow for monitoring fungal pathogens
Fungal diseases are often linked to poverty, which is associated with poor hygiene and sanitation conditions that have been severely worsened by the...
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Transgenic Arabidopsis thaliana plants expressing bacterial γ-hexachlorocyclohexane dehydrochlorinase LinA
Backgroundγ-Hexachlorocyclohexane (γ-HCH), an organochlorine insecticide of anthropogenic origin, is a persistent organic pollutant (POP) that causes...
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Molecular and agro-morphological characterization of new barley genotypes in arid environments
BackgroundGenetic diversity, population structure, agro-morphological traits, and molecular characteristics, are crucial for either preserving...
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Improvement and prediction of the extraction parameters of lupeol and stigmasterol metabolites of Melia azedarach with response surface methodology
BackgroundMelia azedarach is known as a medicinal plant that has wide biological activities such as analgesic, antibacterial, and antifungal effects...
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Microvesicles-delivering Smad7 have advantages over microvesicles in suppressing fibroblast differentiation in a model of Peyronie’s disease
BackgroundThis study compared the differences of microvesicles (MVs) and microvesicles-delivering Smad7 (Smad7-MVs) on macrophage M1 polarization and...
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Minimizing IP issues associated with gene constructs encoding the Bt toxin - a case study
BackgroundAs part of a publicly funded initiative to develop genetically engineered Brassicas (cabbage, cauliflower, and canola) expressing Bacillus...
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Dual release of daptomycin and BMP-2 from a composite of β-TCP ceramic and ADA gelatin
BackgroundAntibiotic-containing carrier systems are one option that offers the advantage of releasing active ingredients over a longer period of...
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Activating the healing process: three-dimensional culture of stem cells in Matrigel for tissue repair
BackgroundTo establish a strategy for stem cell-related tissue regeneration therapy, human gingival mesenchymal stem cells (hGMSCs) were loaded with...
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Co-overexpression of chitinase and β-1,3-glucanase significantly enhanced the resistance of Iranian wheat cultivars to Fusarium
Fusarium head blight (FHB) is a devastating fungal disease affecting different cereals, particularly wheat, and poses a serious threat to global...
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A new mRNA structure prediction based approach to identifying improved signal peptides for bone morphogenetic protein 2
BackgroundSignal peptide (SP) engineering has proven able to improve production of many proteins yet is a laborious process that still relies on...
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A model approach to show that monocytes can enter microporous β-TCP ceramics
β-TCP ceramics are versatile bone substitute materials and show many interactions with cells of the monocyte-macrophage-lineage. The possibility of...
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Nutritional composition, lipid profile and stability, antioxidant activities and sensory evaluation of pasta enriched by linseed flour and linseed oil
Pasta assortments fortified with high quality foods are a modern nutritional trends. This study, explored the effects of fortification with linseed...
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In vitro assessment of the effect of magnetic fields on efficacy of biosynthesized selenium nanoparticles by Alborzia kermanshahica
Cyanobacteria represent a rich resource of a wide array of unique bioactive compounds that are proving to be potent sources of anticancer drugs....
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ECM-mimetic, NSAIDs loaded thermo-responsive, immunomodulatory hydrogel for rheumatoid arthritis treatment
BackgroundRheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease, and it leads to irreversible inflammation in intra-articular...