Search
Search Results
-
Serum Uric Acid and Metabolic Markers in Diabetes
Uric acid, an organic compound, is the end product of purine metabolism in the liver. Hyperuricemic conditions are implicated in the pathogenesis of...
-
Serum Uric Acid and Metabolic Markers in Diabetes
Uric acid, an organic compound, is the end product of purine metabolism in the liver. Hyperuricemic conditions are implicated in the pathogenesis of...
-
Co-delivery of indomethacin and uricase as a new strategy for inflammatory diseases associated with high uric acid
Uric acid is the final metabolite in humans. High level of uric acid chronically induces urate deposition, aggravates kidney damage, and...
-
Uric Acid Mitigates Cognitive Deficits via TFEB-Mediated Microglial Autophagy in Mice Models of Alzheimer’s Disease
Clinical trials have demonstrated the potential neuroprotective effects of uric acid (UA) in Alzheimer’s disease (AD). However, the specific...
-
Eurycoma longifolia alkaloid components ameliorate hyperuricemic nephropathy via regulating serum uric acid level and relieving inflammatory reaction
Hyperuricemia is an independent risk factor for chronic kidney disease. We have previously showed the uric-acid-lowering effect of Eurycoma longifolia ...
-
SARS-CoV-2 omicron variant clearance delayed in breakthrough cases with elevated fasting blood glucose
BackgroundOmicron variant (B.1.1.529) is a dominant variant worldwide. However, the risk factors for Omicron variant clearance are yet unknown. The...
-
Serum uric acid and diabetic peripheral neuropathy: a double-edged sword
Background and objectivesResearch suggests that diabetic peripheral neuropathy (DPN) is related to high serum uric acid (SUA) level, although its...
-
A novel online calculator based on clinical features and hematological parameters to predict total skin clearance in patients with moderate to severe psoriasis
BackgroundTreatment responses to biologic agents vary between patients with moderate to severe psoriasis; while some patients achieve total skin...
-
A semi-mechanistic exposure–response model to assess the effects of verinurad, a potent URAT1 inhibitor, on serum and urine uric acid in patients with hyperuricemia-associated diseases
Verinurad, a uric acid transporter 1 (URAT1) inhibitor, lowers serum uric acid by promoting its urinary excretion. Co-administration with a xanthine...
-
Evaluation of the prognostic ability of serum uric acid for elderly acute coronary syndrome patients with diabetes mellitus: a prospective cohort study
Objective: This study evaluated the prognostic power of serum uric acid (UA) in predicting adverse events in elderly acute coronary syndrome (ACS)...
-
Population pharmacokinetics and dosage optimization of linezolid in Chinese older patients
PurposeTo assess the pharmacokinetics and pharmacodynamics of linezolid in a retrospective cohort of hospitalized Chinese older patients.
...
-
Components of the Purine Metabolism Pathways as Biomarkers for the Early Diagnosis of Diabetes
Type 2 diabetes mellitus (T2DM) is a complex metabolic disorder characterized by persistent hyperglycemia and often hyperlipidemia. T2DM is usually...
-
Impact of calcium channel blockers and angiotensin receptor blockers on hematological parameters in type 2 diabetic patients
Antihypertensive medications have been associated with a reduction in hemoglobin (Hb) levels, leading to clinically significant anemia. We aimed to...
-
The association between lipid profile, oxidized LDL and the components of metabolic syndrome with serum mineral status and kidney function in individuals with obesity
BackgroundMetabolic syndrome (MetS) is presented with a cluster of cardio-metabolic risk factors with widespread prevalence. In the present...
-
Spironolactone reversed hepato-ovarian triglyceride accumulation caused by letrozole-induced polycystic ovarian syndrome: tissue uric acid—a familiar foe
Polycystic ovarian syndrome (PCOS) is a complex endocrine disease among women of reproductive age and is one of the main causes of infertility....
-
Biomarkers of Oxidative Stress in Neonatal Hypoxic-Ischemic Encephalopathy
Neonatal hypoxic-ischemic encephalopathy (HIE) results from the disruption of cerebral oxygen delivery and is a major cause of disability worldwide....
-
Antioxidant compounds from the Arthrospira platensis protect against Bisphenol A-induced nephrotoxicity in rats
ObjectiveA well-known endocrine disruptor, Bisphenol A (BPA) is used as a monomer in the manufacture of polyester, epoxy resin, and polycarbonate...
-
Efficacy and safety of bempedoic acid lipid-lowering therapy: a systematic review and meta-analysis of randomized controlled trials
AimThis systematic review and meta-analysis was conducted to synthesize the efficacy and safety of bempedoic acid in patients requiring...
-
In vitro and in vivo therapeutic antileishmanial potential of ellagic acid against Leishmania donovani in murine model
Parasite of genus Leishmania viz. L. donovani and L. infantum cause visceral leishmaniasis (VL) or Kala-azar, systemic disease with significant...
-
Vitamin C transporter SVCT1 serves a physiological role as a urate importer: functional analyses and in vivo investigations
Uric acid, the end product of purine metabolism in humans, is crucial because of its anti-oxidant activity and a causal relationship with...
