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Tryptophan-kynurenine metabolism: a link between the gut and brain for depression in inflammatory bowel disease
Inflammatory bowel disease (IBD), which mainly includes ulcerative colitis (UC) and Crohn's disease (CD), is a group of chronic bowel diseases that...
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Biogenic Monoamines, Their Precursors, and Metabolites in the Brain of Rats under Experimental Circulatory Failure
Abstract —The aim of the study was to establish the effect of experimental chronic circulatory failure on the levels of biogenic monoamines, their...
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Suicidality in Epilepsy: Does It Share Common Pathogenic Mechanisms with Epilepsy?
Suicidality presents a major global health concern and its association with epilepsy has been suggested. The body of evidence is growing due to...
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Nutritional Approach to the Common Symptoms of Flammer Syndrome
Flammer syndrome (FS) is primarily an ophthalmological phenomenon associated with central and peripheral symptoms, primarily resulting from...
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Monoamine-Hormone Interactions in the Pathogenesis of Anxious Depression
This article discusses the biochemical aspects of interactions between the monoaminergic and hormone systems in the pathogenesis of anxious...
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Role of the Kynurenine Metabolism Pathway in Inflammation-Induced Depression: Preclinical Approaches
Physically ill patients with chronic inflammation often present with symptoms of depression. Our understanding of the pathophysiology of...
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Induction of tyrosine aminotransferase in mice is inhibited by the activated metabolites of ortho-aminoazotoluene
Aminoazo dyes and other hepatocarcinogenic substances inhibit glucocorticoid-mediated induction of adaptive enzymes, including tyrosine...
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Immunosuppression for in vivo research: state-of-the-art protocols and experimental approaches
Almost every experimental treatment strategy using non-autologous cell, tissue or organ transplantation is tested in small and large animal models...
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Effects of acute treatment with a tryptophan-rich protein hydrolysate on plasma amino acids, mood and emotional functioning in older women
RationaleEffective functioning of the neurotransmitter serotonin is important for optimal cognitive and emotional function. Dietary supplements able...
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Adrenal Steroid Hormones
The classical way to evaluate hormone function is to surgically ablate the hormone-producing endocrine gland and substitute it with exogenously...
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The relationship between the monoaminergic and hormonal systems and endogenous intoxication in mixed anxiety-depressive disorder
Sixty one patients were diagnosed with anxiety-depressive disorder. According to the Hamilton depression rating scale and Hamilton anxiety rating...
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IDO in Inflammatory Programming and Immune Suppression in Cancer
Tryptophan catabolism by indoleamine 2,3-dioxygenase (IDO) contributes to immune tolerance and inflammatory programming in a variety of tissue...
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Adrenal Steroid Hormones
The classical way to evaluate hormone function is to surgically ablate the hormone-producing endocrine gland and substitute it with exogenously...
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Alteration in plasma corticosterone levels following long term oral administration of lead produces depression like symptoms in rats
Lead toxicity is known to induce a broad range of physiological, biochemical and behavioral dysfunctions that may result in adverse effects on...
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Biosynthesis of Some Water-Soluble Vitamins and of Their Coenzyme Forms
Thiamin, also known as vitamin B1 can be considered made up of two parts, one being 2-methyl-6-amino-5 hydroxymethyl pyrimidine (“pyrimidine” for the...
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Humoral Factors in Humans Participating in Different Types of Exercise and Training
This chapter provides an overview on some effects of qualitatively and quantitatively different types of exercise stimuli on the blood concentration...
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Predictive Value of IFN-γ-Induced Indoleamine 2,3-Dioxygenase (IDO) Expression in Cancer Patients
Insufficient immunosurveillance is an important aspect in early tumorigenesis and in the pathogenesis of malignant disease. In the later course of...
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Indoleamine 2,3-Dioxygenase and Regulatory Function: Tryptophan Starvation and Beyond
Indoleamine 2,3-dioxygenase (IDO) is an ancestral enzyme that, initially confined to the regulation of tryptophan availability in local tissue...
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Effect of dipterinyl calcium pentahydrate on hepatitis B virus replication in transgenic mice
BackgroundDipterinyl calcium pentahydrate (DCP) has previously been shown to inhibit MDA-MB-231 human breast cancer xenographs in nude mice in a...
