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Is the One-Compartment Model with First Order Absorption a Useful Approximation?
PurposeThe one-compartment model with first order absorption (ka1C) has been extensively used to fit oral data. But when the disposition parameters...
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A Semi-Physiological Three-Compartment Model Describes Brain Uptake Clearance and Efflux of Sucrose and Mannitol after IV Injection in Awake Mice
PurposeTo evaluate a three-compartmental semi-physiological model for analysis of uptake clearance and efflux from brain tissue of the hydrophilic...
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Frequency-domain analysis of membrane polarization in two-compartment model neurons with weak alternating electric fields
Transcranial alternating current stimulation (tACS) is widely used in studying brain functions and the treatment of neuropsychiatric diseases in a...
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Parametric maps of spatial two-tissue compartment model for prostate dynamic contrast enhanced MRI - comparison with the standard tofts model in the diagnosis of prostate cancer
The spatial two-tissue compartment model (2TCM) was used to analyze prostate dynamic contrast enhanced (DCE) MRI data and compared with the standard...
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A three-compartment non-linear model of myocardial cell conduction block during photosensitization
This study constructed a new non-linear model of myocardial electrical conduction block during photosensitization reaction to identify the vulnerable...
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Single-compartment model of a pyramidal neuron, fitted to recordings with current and conductance injection
For single neuron models, reproducing characteristics of neuronal activity such as the firing rate, amplitude of spikes, and threshold potentials as...
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Emergence of stochastic resonance in a two-compartment hippocampal pyramidal neuron model
In vitro studies have shown that hippocampal pyramidal neurons employ a mechanism similar to stochastic resonance (SR) to enhance the detection and...
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On inductive biases for the robust and interpretable prediction of drug concentrations using deep compartment models
Conventional pharmacokinetic (PK) models contain several useful inductive biases guiding model convergence to more realistic predictions of drug...
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Culture of Human Fetal Membranes in a Two Independent Compartment Model: An Ex Vivo Approach
During pregnancy, the fetal membranes composed of the amnion and chorodecidua constitute a selective barrier separating two distinct environments,...
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Compartment-specific multiomic profiling identifies SRC and GNAS as candidate drivers of epithelial-to-mesenchymal transition in ovarian carcinosarcoma
BackgroundOvarian carcinosarcoma (OCS) is an exceptionally aggressive and understudied ovarian cancer type harbouring distinct carcinomatous and...
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Mixed effect estimation in deep compartment models: Variational methods outperform first-order approximations
This work focusses on extending the deep compartment model (DCM) framework to the estimation of mixed-effects. By introducing random effects, model...
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Trimodal single-cell profiling reveals a novel pediatric CD8αα+ T cell subset and broad age-related molecular reprogramming across the T cell compartment
Age-associated changes in the T cell compartment are well described. However, limitations of current single-modal or bimodal single-cell assays,...
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scMultiome analysis identifies a single caudal hindbrain compartment in the develo** zebrafish nervous system
BackgroundA key step in nervous system development involves the coordinated control of neural progenitor specification and positioning. A...
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The Perinucleolar Compartment: A Promising Target to Prevent Cancer Metastasis
The perinucleolar compartment (PNC) is a dynamic nuclear body found in the periphery of the nucleolus of malignant solid tumor cells. PNC contains a...
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Analysis of Non-linear Pharmacokinetics of P-Glycoprotein Substrates in a Microfluidic Device Using a Mathematical Model that Includes an Unstirred Water Layer (UWL) Compartment
PurposeThe purpose of this research is to analyze non-linear pharmacokinetics of P-glycoprotein (P-gp) substrates in a cell based assay of a...
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Novel Quantification of Extracellular Vesicles with Unaltered Surface Membranes Using an Internalized Oligonucleotide Tracer and Applied Pharmacokinetic Multiple Compartment Modeling
PurposeWe developed an accessible method for labeling small extracellular vesicles (sEVs) without disrupting endogenous ligands. Using labeled sEVs...
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Pharmacometric model of agalsidase–migalastat interaction in human: a novel mechanistic model of drug-drug interaction between a therapeutic protein and a small molecule
Recently, a new mechanism of drug–drug interaction (DDI) was reported between agalsidase, a therapeutic protein, and migalastat, a small molecule,...
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Model-based comparison of subcutaneous versus sublingual apomorphine administration in the treatment of motor fluctuations in Parkinson’s disease
The objective of this study was to compare the effectiveness of subcutaneous (SC) and sublingual (SL) formulations of apomorphine for the treatment...
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SalmoSim: the development of a three-compartment in vitro simulator of the Atlantic salmon GI tract and associated microbial communities
BackgroundThe aquaculture sector now accounts for almost 50% of all fish for human consumption and is anticipated to provide 62% by 2030. Innovative...
