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Emerging therapeutic targets in systemic sclerosis
Systemic sclerosis is an autoimmune connective tissue disease which is characterised by vascular perturbations, inflammation, and fibrosis. Although...
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The Immunogenetics of Systemic Sclerosis
Systemic sclerosis (SSc)Systemic sclerosis is a rare disease with a prevalence ranging from 7 to 700 cases per million. Like with most autoimmune...
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Macrophages as determinants and regulators of systemic sclerosis-related interstitial lung disease
BackgroundInterstitial lung disease (ILD) is the primary cause of mortality in systemic sclerosis (SSc), an autoimmune disease characterized by...
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MicroRNA-21a-5p inhibition alleviates systemic sclerosis by targeting STAT3 signaling
BackgroundMicroRNA (miRNA)-21-5p participates in various biological processes, including cancer and autoimmune diseases. However, its role in the...
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Progressive multifocal leukoencephalopathy, advanced ductal breast carcinoma, systemic sclerosis, and checkpoint inhibitors: a therapeutic dilemma
Progressive multifocal leukoencephalopathy (PML) is a demyelinating central nervous system disease infection by JC virus (JCV) in patients with a...
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Establishment of a humanized animal model of systemic sclerosis in which T helper-17 cells from patients with systemic sclerosis infiltrate and cause fibrosis in the lungs and skin
Systemic sclerosis (SSc) is a chronic autoimmune disease characterized by inflammation, microangiopathy, and progressive fibrosis in the skin and...
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The association of IL-33 and systemic sclerosis: a systematic review and meta-analysis
A meta-analysis of the association between IL-33 and these diseases is lacking, and we aimed to perform a meta-analysis of the association between...
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Evaluation of cardiac autonomic control during the 6-min walk test in women with systemic sclerosis
ObjectiveTo evaluate the association between sympathovagal balance and exercise performance, as measured by the 6-min walk test (6MWT), in women with...
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TFH cells in systemic sclerosis
Systemic sclerosis is an autoimmune disease characterized by excessive dermal fibrosis with progression to internal organs, vascular impairment and...
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Examination of the shared genetic architecture between multiple sclerosis and systemic lupus erythematosus facilitates discovery of novel lupus risk loci
Systemic Lupus Erythematosus (SLE) is an autoimmune disease with heterogeneous manifestations, including neurological and psychiatric symptoms....
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Systemic Sclerosis and Pulmonary Disease
Systemic sclerosis is a complex, often progressive, multisystem autoimmune disease. It is commonly categorized into limited cutaneous or diffuse...
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Microorganisms in Pathogenesis and Management of Scleroderma (Systemic Sclerosis)
As environmental triggers, microorganisms are considered largely involved in the multifactorial pathogenetic scenario of autoimmune diseases....
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Complement component C4 structural variation and quantitative traits contribute to sex-biased vulnerability in systemic sclerosis
Copy number (CN) polymorphisms of complement C4 play distinct roles in many conditions, including immune-mediated diseases. We investigated the...
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SARS-CoV-2 spike protein accelerates systemic sclerosis by increasing inflammatory cytokines, Th17 cells, and fibrosis
BackgroundCoronavirus disease 2019 (COVID-19) induces a dysfunctional immune response, inflammation, autoantibody production, and coagulopathy, which...
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PPARγ partial agonist LPSF/GQ-16 prevents dermal and pulmonary fibrosis in HOCl-induced systemic sclerosis (SSc) and modulates cytokine production in PBMC of SSc patients
Thiazolidinediones (TZD) are synthetic molecules that have a range of biological effects, including antifibrotic and anti-inflammatory, and they may...
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Real life data on nintedanib safety: idiopathic pulmonary fibrosis versus systemic sclerosis-interstitial lung disease and strategies adopted to manage adverse effects
ObjectiveNintedanib (NIN) is an antifibrotic drug approved to slow the progression of idiopathic pulmonary fibrosis (IPF) and systemic...
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Distinct genome-wide DNA methylation and gene expression signatures in classical monocytes from African American patients with systemic sclerosis
BackgroundSystemic sclerosis (SSc) is a multisystem autoimmune disorder that has an unclear etiology and disproportionately affects women and African...
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Novel insights into systemic sclerosis using a sensitive computational method to analyze whole-genome bisulfite sequencing data
BackgroundAbnormal DNA methylation is thought to contribute to the onset and progression of systemic sclerosis. Currently, the most comprehensive...
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The Role of Ferroptosis in Amyotrophic Lateral Sclerosis Treatment
Amyotrophic lateral sclerosis (ALS) is a rare neurodegenerative disease with a challenging treatment landscape, due to its complex pathogenesis and...
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Integrative genomic expression analysis reveals stable differences between lung cancer and systemic sclerosis
BackgroundThe incidence and mortality of lung cancer are the highest among all cancers. Patients with systemic sclerosis show a four-fold greater...
