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Elucidation of Tartaric Acid-Assisted Supersaturation Maintenance of Dipyridamole by Eudragit® E100
PurposeThe purpose of this study was to investigate the effect of tartaric acid on the maintenance of dipyridamole supersaturation using Eudragit...
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Study on a Novel Transdermal Therapeutic System that Combines the Achievement of Supersaturation by pH-shift Method and User–Activated System
PurposeTo enable the practical application of a novel transdermal therapeutic system (TTS) that combines the achievement of supersaturation by the...
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An Insight into Eudragit S100 Preserving Mechanism of Cinnarizine Supersaturation
Generally, supersaturation of weakly basic drug solution in the gastrointestinal tract can be followed by precipitation, and this can compromise the...
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Enhancing the Dissolution of Flutamide Through Supersaturation Using Beta-Cyclodextrin: a Promising Approach for Improved Solubility of Poorly Water-Soluble Drugs
PurposeThe study aims to explore the potential of amorphous solid dispersion (ASD) technology in improving the solubility and bioavailability of...
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Recent Advances in Enhancement of Dissolution and Supersaturation of Poorly Water-Soluble Drug in Amorphous Pharmaceutical Solids: A Review
Amorphization is one of the most effective pharmaceutical approaches to enhance the dissolution and oral bioavailability of poorly water-soluble...
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Insights into the Role of Compendial/Biorelevant Media on the Supersaturation Behaviour of Drug Combination (Drug-Drug Interaction) and Precipitation Inhibition by Polymers
Combination drug therapy (CDT) plays an immense role in the treatment of various diseases such as malaria, hypertension, cancer, HIV-AIDS,...
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pH-Dependent supersaturation from amorphous solid dispersions of weakly basic drugs
PurposeIn amorphous solid dispersions (ASDs), the chemical potential of a drug can be reduced due to mixing with the polymer in the solid matrix, and...
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Impact of Surfactants on Polymer Maintained Nifedipine Supersaturation in Aqueous Solution
PurposeTo study the impact of different surfactants on the supersaturation of nifedipine stabilized with HPMC and PVP-VA.
MethodsDifferent kinds of...
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Impact of Drug-Polymer Interaction in Amorphous Solid Dispersion Aiming for the Supersaturation of Poorly Soluble Drug in Biorelevant Medium
The aim of this study was to investigate the influence of the production method and the polymeric carrier on the ability to generate and maintain the...
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Characterization of Grades of HPMCAS Spray Dried Dispersions of Itraconazole Based on Supersaturation Kinetics and Molecular Interactions Impacting Formulation Performance
PurposeThe objective was to characterize hydroxypropyl methylcellulose acetate succinate (HMPCAS) grades L, M, and H to enhance itraconazole (ITZ)...
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Impact of Processing Methods on the Physico-chemical Properties of Posaconazole Amorphous Solid Dispersions
Background & PurposeDifferent methods have been exploited to generate amorphous solid dispersions (ASDs) of poorly water-soluble drugs. However, the...
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Quantifying
In Vivo Luminal Drug Solubilization -Supersaturation-Precipitation Profiles to Explain the Performance of Lipid Based FormulationsPurposeTo evaluate the role of supersaturation in the in vivo absorption of fenofibrate (FFB), after oral administration in a medium-chain...
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Effect of Structurally Related Compounds on Desupersaturation Kinetics of Indomethacin
PurposeThe pharmaceutical literature contains examples wherein desupersaturation from high concentrations does not proceed to equilibrium...
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Interplay of Adsorption, Supersaturation and the Presence of an Absorptive Sink on Drug Release from Mesoporous Silica-Based Formulations
PurposeMesoporous silica-based formulations of poorly soluble drugs may exhibit incomplete drug release due to drug remaining adsorbed on the silica...
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In Vitro and In Vivo Assessment of the Potential of Supersaturation to Enhance the Absorption of Poorly Soluble Basic Drugs
PurposeDelaying precipitation of weakly basic drugs in supersaturated state following their transition from the acidic gastric environment to the...
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Formulation of Cinnarizine for Stabilization of Its Physiologically Generated Supersaturation
Physiologically generated supersaturation and subsequent crystallization of a weakly basic drug in the small intestine leads to compromised...
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Dissolution Profiles of Carbamazepine Cocrystals with Cis–Trans Isomeric Coformers
PurposeThe purpose of the present study was to investigate the dissolution profiles of cocrystals with cis–trans isomeric coformers. Previously, the...
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Dissolution Profiles of Immediate Release Products of Various Drugs in Biorelevant Bicarbonate Buffer: Comparison with Compendial Phosphate Buffer
PurposeThe purpose of this study was to clarify the extent to which the dissolution profiles of immediate release (IR) products of various drugs...
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Can the Oral Bioavailability of the Discontinued Prostate Cancer Drug Galeterone Be Improved by Processing Method? KinetiSol® Outperforms Spray Drying in a Head-to-head Comparison
Galeterone, a novel prostate cancer candidate treatment, was discontinued after a Phase III clinical trial due to lack of efficacy. Galeterone is...
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Vitamin C Improves Dasatinib Concentrations Under Hypochlorhydric Conditions of the Simulated Stomach Duodenum Model
PurposepH-dependent drug-drug interactions (DDIs) with poorly soluble, weakly basic drugs may lead to clinical implications. Dasatinib is a tyrosine...
