Search
Search Results
-
First time identification of subconjunctival Dirofilaria immitis in Turkey: giant episcleral granuloma mimicking scleritis
Dirofilariasis is a vector-borne disease that is present worldwide. This report describes a giant subconjunctival granuloma which mimics scleritis,...
-
Shear-Thinning Viscous Materials for Subconjunctival Injection of Microparticles
While drug-loaded microparticles (MPs) can serve as drug reservoirs for sustained drug release and therapeutic effects, needle clogging by MPs poses...
-
Extracellular vesicle encapsulated nicotinamide delivered via a trans-scleral route provides retinal ganglion cell neuroprotection
The progressive and irreversible degeneration of retinal ganglion cells (RGCs) and their axons is the major characteristic of glaucoma, a leading...
-
Influence of discontinuation of prophylactic antimicrobial agent for trabeculectomy
BackgroundThere is no unified view of the necessity of prophylactic antimicrobial agents in trabeculectomy. Preoperative prophylactic antimicrobial...
-
Loiasis Disease Typical and Atypical Clinical Manifestations, Burden, and Local Aspects of the Disease
Loiasis is a multifaceted disease with numerous signs and symptoms. The typical symptoms of “eyeworm” (subconjunctival migration of a Loa loa adult...
-
MiR-146a reduces fibrosis after glaucoma filtration surgery in rats
PurposeTo explore the impact of microRNA 146a (miR-146a) and the underlying mechanisms in profibrotic changes following glaucoma filtering surgery...
-
Autochthonous Onchocerca lupi infection of a domestic dog in Austria
Onchocerca lupi is an emerging canine ocular pathogen with zoonotic potential. In Europe, known endemic areas are the Iberian Peninsula and Greece,...
-
Ocular Drug Delivery: a Comprehensive Review
The human eye is a sophisticated organ with distinctive anatomy and physiology that hinders the passage of drugs into targeted ophthalmic sites....
-
Liposomal drug delivery system for anti-inflammatory treatment after cataract surgery: a phase I/II clinical trial
Liposomes as a drug delivery system may overcome the problems associated with non-compliance to eyedrops and inadequate control of inflammation after...
-
Serotype survey of AAV gene delivery via subconjunctival injection in mice
AAV gene therapy approaches in the posterior eye resulted in the first FDA-approved gene therapy-based drug. However, application of AAV vectorology...
-
Novel homozygous frameshift variant in the ATCAY gene in an Iranian patient with Cayman cerebellar ataxia; expanding the neuroimaging and clinical features: a case report
BackgroundPathogenic variants in the ATCAY gene are associated with a rare autosomal recessive disorder called Cayman cerebellar ataxia. Affected...
-
Lysine Demethylase 1B Promotes Tear Secretion Disorder in Sjogren’s Syndrome by Regulating the PAX6/CLU Axis
The impacts of lysine demethylase 1B (KDM1B) have been probed in multiple diseases, but the effects of KDM1B on SS remained obscure. The study aimed...
-
Effect of connective tissue growth factor gene editing using adeno-associated virus–mediated CRISPR–Cas9 on rabbit glaucoma filtering surgery outcomes
Suppressing excessive wound healing responses is critical to ensure surgical success in glaucoma filtration surgery (GFS). Currently used adjunctive...
-
Ophthalmic and Otic Drug Delivery
This chapter introduces special considerations and formulation techniques for ophthalmic and otic drug delivery. Types of ophthalmic dosage forms are...
-
Loiasis
Loiasis, also known as African eye worm, is a vector-borne parasitic disease caused by the filarial nematode Loa loa and transmitted by the bite of...
-
Corticosteroids in ophthalmology: drug delivery innovations, pharmacology, clinical applications, and future perspectives
Corticosteroids remain the mainstay of the treatment for various ocular conditions affecting the ocular surface, anterior and posterior segments of...
-
Nanomedicine and drug delivery to the retina: current status and implications for gene therapy
Blindness affects more than 60 million people worldwide. Retinal disorders, including age-related macular degeneration (AMD), diabetic retinopathy...
-
Ocular thelaziosis: an emerging human parasitosis in Europe
Ocular thelaziosis is a parasitosis distributed mainly in East Asia, but increasingly described in Europe in different domestic and wild animals,...
-
-
Progress in the Application of Microneedles in Eye Disorders and the Proposal of the Upgraded Microneedle with Spinule
PurposeIn the local administration methods for treating eye diseases, the application of microneedles has great potential due to the shortcomings of...
