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Identification of prognostic stemness-related genes in kidney renal papillary cell carcinoma
BackgroundKidney renal papillary cell carcinoma (KIRP) is the second most prevalent malignant cancer originating from the renal epithelium. Nowadays,...
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Characterization of stemness features and construction of a stemness subtype classifier to predict survival and treatment responses in lung squamous cell carcinoma
BackgroundCancer stemness has been proven to affect tumorigenesis, metastasis, and drug resistance in various cancers, including lung squamous cell...
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Deep dissection of stemness-related hierarchies in hepatocellular carcinoma
BackgroundIncreasing evidence suggests that hepatocellular carcinoma (HCC) stem cells (LCSCs) play an essential part in HCC recurrence, metastasis,...
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Low-density lipoprotein receptor promotes crosstalk between cell stemness and tumor immune microenvironment in breast cancer: a large data-based multi-omics study
BackgroundTumor cells with stemness in breast cancer might facilitate the immune microenvironmentās suppression process and led to anti-tumor immune...
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CDC45 promotes the stemness and metastasis in lung adenocarcinoma by affecting the cell cycle
ObjectiveThis study aimed to assess the functions of cell division cycle protein 45 (CDC45) in Non-small cell lung cancer (NSCLC) cancer and its...
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An integrated investigation of sulfotransferases (SULTs) in hepatocellular carcinoma and identification of the role of SULT2A1 on stemness
The cytosolic sulfotransferases (SULTs) are phase II conjugating enzymes, which are widely expressed in the liver and mainly mediate the sulfation of...
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RACGAP1 promotes the progression and poor prognosis of lung adenocarcinoma through its effects on the cell cycle and tumor stemness
ObjectionInvestigating the key genes and mechanisms that influence stemness in lung adenocarcinoma.
MethodsFirst, consistent clustering analysis was...
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The BET degrader ZBC260 suppresses stemness and tumorigenesis and promotes differentiation in triple-negative breast cancer by disrupting inflammatory signaling
BackgroundBreast cancer stem cells (BCSCs) are resistant to standard therapies, facilitate tumor dissemination, and contribute to relapse and...
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Targeted silencing of SOCS1 by DNMT1 promotes stemness of human liver cancer stem-like cells
BackgroundHuman liver cancer stem-like cells (HLCSLCs) are widely acknowledged as significant factors in the recurrence and eradication of...
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Essential role of PLD2 in hypoxia-induced stemness and therapy resistance in ovarian tumors
BackgroundHypoxia in solid tumors is an important source of chemoresistance that can determine poor patient prognosis. Such chemoresistance relies on...
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TRIM58 downregulation maintains stemness via MYH9-GRK3-YAP axis activation in triple-negative breast cancer stem cells
TRIM58 is a member of the TRIM protein family, which possess with E3 ubiquitin ligase activities. Studies have revealed that low expression of TRIM58...
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Integrative multi-omics analysis unveils stemness-associated molecular subtypes in prostate cancer and pan-cancer: prognostic and therapeutic significance
BackgroundProstate cancer (PCA) is the fifth leading cause of cancer-related deaths worldwide, with limited treatment options in the advanced stages....
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m6A-modified circABCC4 promotes stemness and metastasis of prostate cancer by recruiting IGF2BP2 to increase stability of CCAR1
Prostate cancer (PCa) is a malignant tumor of the urinary system. CircABCC4 has been demonstrated to promote the development of PCa; however, its...
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Pancreatic cancer stemness: dynamic status in malignant progression
Pancreatic cancer (PC) is one of the most aggressive malignancies worldwide. Increasing evidence suggests that the capacity for self-renewal,...
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Cuproptosis engages in c-Myc-mediated breast cancer stemness
BackgroundIntra-tumoral heterogeneity (ITH) is a distinguished hallmark of cancer, and cancer stem cells (CSCs) contribute to this malignant...
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BCL7B, a SWI/SNF complex subunit, orchestrates cancer immunity and stemness
Cancer is one of the main causes of human death. Here, we focus on the B-cell lymphoma 7 protein family member B (BCL7B) gene, an accessory subunit...
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IL20RB signaling enhances stemness and chemotherapy resistance in pancreatic cancer
ObjectivePancreatic cancer is an aggressive malignancy with high mortality, and cancer cell stemness and related drug resistance are considered...
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BEX1 supports the stemness of hepatoblastoma by facilitating Warburg effect in a PPARĪ³/PDK1 dependent manner
BackgroundHepatoblastoma (HB) is a highly aggressive paediatric malignancy that exhibits a high presence of cancer stem cells (CSCs), which related...
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A novel stemness-hypoxia-related signature for prognostic stratification and immunotherapy response in hepatocellular carcinoma
BackgroundThe specific differentiation potential, unlimited proliferation, and self-renewal capacity of cancer stem cells (CSCs) are closely related...
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Rab11-FIP4 interacts with ARF5 to promote cancer stemness in hepatocellular carcinoma
Recent studies suggest that Rab11-family interacting proteins (Rab11-FIPs) play an important role in tumorigenesis and progression. Among the...
