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Somatosensory cortex and central amygdala regulate neuropathic pain-mediated peripheral immune response via vagal projections to the spleen
Pain involves neuroimmune crosstalk, but the mechanisms of this remain unclear. Here we showed that the splenic T helper 2 (T H 2) immune cell response...
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Features of Spleen Development in Newborn Rats Exposed to Endocrine Disrupter Dichlorodiphenyltrichloroethane during the Prenatal Period
The development of the spleen in newborn male Wistar rats exposed to low-dose endocrine disruptor dichlorodiphenyltrichloroethane during the prenatal...
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Correlation between spleen density and prognostic outcomes in patients with colorectal cancer after curative resection
ObjectiveThe objective of this study was to investigate the correlation between spleen density and the prognostic outcomes of patients who underwent...
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The spleen is the graveyard of CD4+ cells in patients with immunological failure of visceral leishmaniasis and AIDS
BackgroundVisceral leishmaniasis (VL), or kala-azar, is a common comorbidity in patients with AIDS in endemic areas. Many patients continue to...
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Standardization of DNA extraction from paraffinized spleen samples: molecular diagnosis of human malaria
BackgroundPlasmodium vivax is the main species responsible for human malaria in Brazil, and one of its manifestations is splenic malaria, though...
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Voltammetry in the spleen assesses real-time immunomodulatory norepinephrine release elicited by autonomic neurostimulation
BackgroundThe noradrenergic innervation of the spleen is implicated in the autonomic control of inflammation and has been the target of...
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Caudal DMN neurons innervate the spleen and release CART peptide to regulate neuroimmune function
BackgroundInflammation is a fundamental biological response to injury and infection, which if unregulated can contribute to the pathophysiology of...
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The Rarity of Metastasis to the Spleen — a Phenomenon with an Unknown Mechanism
The review analyses the frequency of malignant tumors metastasizing to the spleen. The facts are presented of a higher frequency of metastasis to the...
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Tannic acid may ameliorate doxorubicin-induced changes in oxidative stress parameters in rat spleen
Doxorubicin (DOX) is a potent and broad-spectrum drug widely used in the treatment of cancer. However, the toxicity and side effects of DOX on...
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MRI-based inter- and intrafraction motion analysis of the pancreatic tail and spleen as preparation for adaptive MRI-guided radiotherapy in neuroblastoma
BackgroundIn pediatric radiotherapy treatment planning of abdominal tumors, dose constraints to the pancreatic tail/spleen are applied to reduce late...
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FACS to Identify Immune Subsets in Mouse Brain and Spleen
Flow cytometry enables the multi-parametric quantification of cell types, especially in immunophenoty** of unique immune cell subsets that can... -
Bulk RNA-seq Assessment of Murine Spleen Using a Portable MinION Sequencing Device
Comprehensive profiling of the transcriptome reflects the dynamic changes in complex regulator interactions between genes and proteins in the... -
Effects of hyperventilation on oxygenation, apnea breaking points, diving response, and spleen contraction during serial static apneas
PurposeHyperventilation is considered a major risk factor for hypoxic blackout during breath-hold diving, as it delays the apnea breaking point....
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Identification and protective role of CD34+ stromal cells/telocytes in experimental autoimmune encephalomyelitis (EAE) mouse spleen
Experimental autoimmune encephalomyelitis (EAE) is a classical animal model of human multiple sclerosis (MS) that is most commonly used to study the...
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The role of spleen volume change in predicting immunotherapy response in metastatic renal cell carcinoma
IntroductionResistance to immune checkpoint inhibitors (ICI) is a significant issue in metastatic renal cell carcinoma (mRCC), as it is in the...
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Discovery of highly immunogenic spleen-resident FCGR3+CD103+ cDC1s differentiated by IL-33-primed ST2+ basophils
Recombinant interleukin-33 (IL-33) inhibits tumor growth, but the detailed immunological mechanism is still unknown. IL-33-mediated tumor suppression...
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Dynamics of Changes in the cAMP/cGMP Concentration Ratio in the Thymus and Spleen of Laboratory Mice during Vaccination against Plague and Tularemia against the Background of Immunomodulation
Vaccine strains Yersinia pestis EV NIIEG at a dose of 10 3 CFU and Francisella tularensis 15 NIIEG at a dose of 10 2 CFU induced changes in the...
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Atazanavir-Concentrate Loaded Soft Gelatin Capsule for Enhanced Concentration in Plasma, Brain, Spleen, and Lymphatics
This study investigates the development of atazanavir-concentrate loaded soft gelatin capsule for achieving enhanced atazanavir (ATV) concentration...
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RNA sequencing reveals dynamic expression of spleen lncRNAs and mRNAs in Beagle dogs infected by Toxocara canis
BackgroundToxocara canis is a cosmopolitan parasite with a significant adverse impact on the health of humans and animals. The spleen is a major...