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Structural insights into somatostatin receptor 5 bound with cyclic peptides
Somatostatin receptor 5 (SSTR5) is highly expressed in ACTH-secreting pituitary adenomas and is an important drug target for the treatment of...
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Comparative evaluation of somatostatin and CXCR4 receptor expression in different types of thyroid carcinoma using well-characterised monoclonal antibodies
BackgroundPapillary and follicular thyroid carcinomas can be treated surgically and with radioiodine therapy, whereas therapeutic options for...
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The Distinct Characteristics of Somatostatin Neurons in the Human Brain
Somatostatin cells are frequently described as a major population of GABAergic neurons in the cerebral cortex. In this study, we performed a...
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Novel Somatostatin Receptor-4 Agonist SM-I-26 Mitigates Lipopolysaccharide-Induced Inflammatory Gene Expression in Microglia
Somatostatin receptor subtype 4 (SSTR4) is expressed in BV2 microglia, suggesting that SSTR4 agonists may impact microglia function. This study...
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Genetic Ablation of Dentate Hilar Somatostatin-Positive GABAergic Interneurons is Sufficient to Induce Cognitive Impairment
Aging is often associated with a decline in cognitive function. A reduction in the number of somatostatin-positive (SOM + ) interneurons in the dentate...
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Action of GABAB receptor on local network oscillation in somatosensory cortex of oral part: focusing on NMDA receptor
The balance of activity between glutamatergic and GABAergic networks is particularly important for oscillatory neural activities in the brain. Here,...
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Transcriptome of GH-producing pituitary neuroendocrine tumours and models are significantly affected by somatostatin analogues
Pituitary neuroendocrine tumours (PitNETs) are neoplasms of the pituitary that overproduce hormones or cause unspecific symptoms due to mass effect....
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Transdermal delivery of a somatostatin receptor type 2 antagonist using microneedle patch technology for hypoglycemia prevention
Hypoglycemia is a serious and potentially fatal complication experienced by people with insulin-dependent diabetes. The complication is usually...
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Somatostatin contributes to long-term potentiation at excitatory synapses onto hippocampal somatostatinergic interneurons
Somatostatin-expressing interneurons (SOM-INs) are a major subpopulation of GABAergic cells in CA1 hippocampus that receive excitation from pyramidal...
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mTORC1-mediated acquisition of reward-related representations by hippocampal somatostatin interneurons
Plasticity of principal cells and inhibitory interneurons underlies hippocampal memory. Bidirectional modulation of somatostatin cell mTORC1...
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Object location learning in mice requires hippocampal somatostatin interneuron activity and is facilitated by mTORC1-mediated long-term potentiation of their excitatory synapses
Hippocampus-dependent learning and memory originate from long-term synaptic changes in hippocampal networks. The activity of CA1 somatostatin...
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Receptor-Specific Radionuclide Therapy
Nuclear medicine is a medical specialty that uses radiopharmaceuticals for diagnostic imaging or therapy. This radiopharmaceutical compound consists...
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Somatostatin-Positive Neurons in the Rostral Zona Incerta Modulate Innate Fear-Induced Defensive Response in Mice
Defensive behaviors induced by innate fear or Pavlovian fear conditioning are crucial for animals to avoid threats and ensure survival. The zona...
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Capsaicin, The Vanilloid Receptor TRPV1 Agonist in Neuroprotection: Mechanisms Involved and Significance
Hot peppers, also called chilli, chilli pepper, or paprika of the plant genus Capsicum (family Solanaceae ), are one of the most used vegetables and...
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Initiation of Somatostatin analogues for neuroendocrine tumor patients: a cost-effectiveness analysis
Background & AimsGastroenteropancreatic neuroendocrine tumors (GEP-NETs) are heterogeneous neoplasms. Although some have a relatively benign and...
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Role and recent progress of P2Y12 receptor in cancer development
P2Y12 receptor (P2Y12R) is an adenosine-activated G protein-coupled receptor (GPCR) that plays a central role in platelet function, hemostasis, and...
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Role of Endorphins in Breast Cancer Pathogenesis and Recovery
Understanding the relationship between stress and breast cancer development is essential to preventing and alleviating the cancer. Recent research...