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Solid Lipid Nanoparticles for the Management of Allergic Airway Diseases
The allergic airway diseases comprise both allergic rhinitis and asthma which are amongst the top three ailments of the twenty-first century...
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Microfluidic encapsulation of enzymes and steroids within solid lipid nanoparticles
The production of solid lipid nanoparticles (SLNs) is challenging, especially when considering the incorporation of biologics. A novel in-house...
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A Quality by Design Approach for Optimizing Solid Lipid Nanoparticles of Bedaquiline for Improved Product Performance
Bedaquiline (BQ) solid lipid nanoparticles (SLNs), which have previously been formulated for parenteral administration, have a risk of patient...
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Construct Fluorescent Solid Lipid Nanoparticles from Bacterial Outer Membrane Vesicles to Study their Properties and Potential Applications as In Vivo and Invitro Imaging Agents
In this study, the new solid lipid nanoparticles were created by combining fluorescent dye, fatty acid, lipid, and bacterial outer membranes. The...
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Solid Lipid Nanoparticles-Based Drug and Gene Delivery to Macrophages
The current chapter discusses targeting macrophages with solid lipid nanoparticles (SLNs) loaded with drugs and genetic material. Macrophages are the...
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Rhein methotrexate-decorated solid lipid nanoparticles altering adjuvant arthritis progression through endoplasmic reticulum stress-mediated apoptosis
Methotrexate (MTX) and diacerein (DIA) are two of the most potent disease-modifying anti-rheumatic drugs used for the treatment of rheumatoid...
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High payload dexamethasone palmitate-loaded solid lipid nanoparticles for enhanced anti-inflammatory effects in acute skin inflammation model
PurposeDexamethasone palmitate (DXPL) is a lipophilic derivative of dexamethasone (DXM) used to overcome the low drug-loading capacity and immediate...
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Application of Design of Experiment in the Optimization of Apixaban-Loaded Solid Lipid Nanoparticles: In Vitro and In Vivo Evaluation
Solid lipid nanoparticles (SLnPs) are usually utilized as lipid-based formulations for enhancing oral bioavailability of BCS class IV drugs....
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Lipid-Based Nanocarriers for the Delivery of Phytoconstituents
Over the last decade, lipid-based nanocarriers have proven to be a good carrier for many pharmaceutical medications. Different types of lipid-based...
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QbD-Driven Development and Characterization of Solid Lipid Nanoparticles (SLNs)–Based Nanogel of Luliconazole for the Effective Management of Dermal Fungal Infection
PurposeSolid lipid nanoparticles (SLNs) have shown tremendous utility in the topical delivery of such anti-fungal moieties. Hence, it was aimed to...
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Drug Delivery Systems: Lipid Nanoparticles Technology in Clinic
Drug delivery systems (DDS) aid the administration of therapeutic cargoes to desired tissues to evoke a pharmacological response with minimal adverse...
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The 60-year evolution of lipid nanoparticles for nucleic acid delivery
Delivery of genetic information to the interior of target cells in vivo has been a major challenge facing gene therapies. This barrier is now being...
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Development of andrographolide-loaded solid lipid nanoparticles for lymphatic targeting: Formulation, optimization, characterization, in vitro, and in vivo evaluation
Andrographolide, the primary bioactive constituent of Andrographis paniculata , is a promising natural substance with numerous pharmacotherapy uses....
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Development and Characterization of 5-Fluorouracil Solid Lipid Nanoparticles for Treatment of Colorectal Cancer
PurposeIn this study, the oral nanotherapeutic approach of 5-fluorouracil solid lipid nanoparticles (5-FU SLNs) for the synergistic treatment of...
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RETRACTED ARTICLE: Assessment of anti-psoriatic activity of bakuchiol-loaded solid lipid nanoparticles-based gel: design, characterization, and mechanistic insight via NF-kB signaling pathway
The aim of the current study is to evaluate the anti-psoriatic potential of bakuchiol (Bak) loaded solid lipid nanoparticles (SLNs) via modulating...
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Immunogenicity of lipid nanoparticles and its impact on the efficacy of mRNA vaccines and therapeutics
Several studies have utilized a lipid nanoparticle delivery system to enhance the effectiveness of mRNA therapeutics and vaccines. However, these...
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The development of a solid lipid nanoparticle (SLN)-based lacticin 3147 hydrogel for the treatment of wound infections
Chronic wounds affect millions of people globally. This number is set to rise with the increasing incidence of antimicrobial-resistant bacterial...
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Lipid nanoparticles for gene therapy in ocular diseases
ObjectivesLipid nanoparticles, as a nucleic acid delivery system, have been used as an alternative to treat ocular diseases, since they can cross the...
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Targeting pentamidine towards CD44-overexpressing cells using hyaluronated lipid-polymer hybrid nanoparticles
Biodegradable nanocarriers possess enormous potential for use as drug delivery systems that can accomplish controlled and targeted drug release, and...
