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Single-domain antibody-based protein degrader for synucleinopathies
Synucleinopathies are a group of neurodegenerative diseases characterized by the accumulation of α-synuclein (α-syn) in the brain, leading to motor...
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A novel human single-domain antibody-drug conjugate targeting CEACAM5 exhibits potent in vitro and in vivo antitumor activity
Leveraging the specificity of antibody to deliver cytotoxic agent into tumor, antibody-drug conjugates (ADCs) have become one of the hotspots in the...
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A single-domain antibody for the detection of pathological Tau protein in the early stages of oligomerization
BackgroundSoluble oligomeric forms of Tau protein have emerged as crucial players in the propagation of Tau pathology in Alzheimer’s disease (AD)....
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A high affinity and specificity anti-HER2 single-domain antibody (VHH) that targets trastuzumab’s epitope with versatile biochemical, biological, and medical applications
In the past decade, various single-domain antibodies from llamas, also known as VHH or nanobody, have been discovered with applications in tumor...
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A single-domain antibody detects and neutralises toxic Aβ42 oligomers in the Alzheimer’s disease CSF
BackgroundAmyloid-β 42 (Aβ 42 ) aggregation consists of a complex chain of nucleation events producing soluble oligomeric intermediates, which are...
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Single-Domain Antibody-Gold Nanoparticle Bioconjugates as Immunosensors for the Detection of Hantaviruses
IntroductionHantavirus, a zoonotic pathogen, causes severe syndromes like hemorrhagic fever with renal syndrome (HFRS), sometimes fatal in humans....
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Identification and Characterization of a Novel Single Domain Antibody Against Ebola Virus
Ebola virus (EBOV) belongs to the Filoviridae family and causes severe illnesses such as hemorrhagic fever with a high mortality rate up to 90%. Now...
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The Search for Single-Domain Antibodies Interacting with the Receptor-Binding Domain of SARS-CoV-2 Surface Protein
We performed a search for nanoantibodies that specifically interact with the receptor-binding domain (RBD) of the SARS-CoV-2 surface protein. The...
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Structural Classification of CDR-H3 in Single-Domain VHH Antibodies
The immune systems protect vertebrates from foreign molecules or antigens, and antibodies are important mediators of this system. The sequences and...
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Receptors in Immunodiagnostics: Antibodies, Antibody Fragments, Single Domain Antibodies and Aptamers
Immunodiagnostics that can detect the target analytes such as organic molecules, pathogens, synthetic chemicals, in the sample with high sensitivity...
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Thermal Stability Estimation of Single Domain Antibodies Using Molecular Dynamics Simulations
In this chapter, we describe a protocol to estimate the thermal stability of single domain antibodies (sdAbs) using molecular dynamics (MD)...
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Antibody-Based Biotherapeutics in Inflammatory Diseases
Inflammatory diseases encompass a broad and diverse spectrum of serious chronic disorders, many of which have significant need for safe and effective...
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Generation of HIV-resistant cells with a single-domain antibody: implications for HIV-1 gene therapy
The cure or functional cure of the “Berlin patient” and “London patient” indicates that infusion of HIV-resistant cells could be a viable treatment...
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An Antibody-Dependent Cellular Cytotoxicity Assay for Detecting Ocrelizumab Neutralizing Antibody
Ocrelizumab (OCREVUS®) is a humanized anti-CD20 monoclonal antibody approved for the treatment of adult patients with relapsing multiple sclerosis...
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PI3Kγ in B cells promotes antibody responses and generation of antibody-secreting cells
The differentiation of naive and memory B cells into antibody-secreting cells (ASCs) is a key feature of adaptive immunity. The requirement for...
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Information-Driven Antibody–Antigen Modelling with HADDOCK
In the recent years, therapeutic use of antibodies has seen a huge growth, "due to their inherent proprieties and technological advances in the...
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Antibody-displaying extracellular vesicles for targeted cancer therapy
Extracellular vesicles (EVs) function as natural delivery vectors and mediators of biological signals across tissues. Here, by leveraging these...
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Engineered Therapeutic Antibody Against SARS-CoV-2
Purpose of ReviewThe success and failure of therapeutic antibodies against SARS-CoV-2 offer a lesson on therapeutic antibody design and development.
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Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC) in Cancer
Antibody-dependet cell mediated cytotoxicity is a well known strategy to kill dangerous cells. Some antibody have the potential to bind IgG Fc...
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Recombinant Antibody Fragments for Immunotherapy of Parkinson’s Disease
Parkinson’s disease (PD) is the second most common age-related neurodegenerative disorder. Multiple genetic and environmental factors leading to...