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Functional similarity affects similarity in partner composition in flea-mammal networks
Functional signal in an interaction network is a phenomenon in which species resembling each other in their traits interact with similar partners. We...
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Dissolution Profile Similarity Assessment—Best Practices, Decision Trees and Global Harmonization
During the write-up of the meeting summary reports from the 2019 dissolution similarity workshop held at the University of Maryland’s Center of...
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Robust estimation of cortical similarity networks from brain MRI
Structural similarity is a growing focus for magnetic resonance imaging (MRI) of connectomes. Here we propose Morphometric INverse Divergence (MIND),...
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DISSOLUTION PROFILE SIMILARITY ANALYSES—STATISTICAL PRINCIPLES, METHODS AND CONSIDERATIONS
The pharmaceutical industry and regulatory agencies rely on dissolution similarity testing to make critical product decisions as part of drug product...
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Changes in microstructural similarity of hippocampal subfield circuits in pathological cognitive aging
The hippocampal networks support multiple cognitive functions and may have biological roles and functions in pathological cognitive aging (PCA) and...
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Comprehensive evaluation of similarity between synthetic and real CT images for nasopharyngeal carcinoma
BackgroundAlthough magnetic resonance imaging (MRI)-to-computed tomography (CT) synthesis studies based on deep learning have significantly...
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Current Approaches for Dissolution Similarity Assessment, Requirements, and Global Expectations
This report summarizes podium presentations and breakout sessions from the second day of the 2019 M-CERSI workshop on In Vitro Dissolution Similarity...
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Demonstration of Physicochemical and Functional Similarity of the Biosimilar BAT1806/BIIB800 to Reference Tocilizumab
Background and ObjectiveTocilizumab is an immunoglobulin G1 monoclonal antibody targeting the interleukin-6 receptor (IL-6R). BAT1806/BIIB800...
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Incorporating genetic similarity of auxiliary samples into eGene identification under the transfer learning framework
BackgroundThe term eGene has been applied to define a gene whose expression level is affected by at least one independent expression quantitative...
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Lead equivalence testing using a custom-built testing kit
Radiation protective garments should undergo a quality assurance regime comprising of an acceptance test of the lead equivalence before the garment...
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Channel-wise attention enhanced and structural similarity constrained cycleGAN for effective synthetic CT generation from head and neck MRI images
BackgroundMagnetic resonance imaging (MRI) plays an increasingly important role in radiotherapy, enhancing the accuracy of target and organs at risk...
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Grou** of orally ingested silica nanomaterials via use of an integrated approach to testing and assessment to streamline risk assessment
BackgroundNanomaterials can exist in different nanoforms (NFs). Their grou** may be supported by the formulation of hypotheses which can be...
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Characterization for the Similarity Assessment between Proposed Biosimilar SB12 and Eculizumab Reference Product Using a State-of-the-Art Analytical Method
BackgroundSB12 is being developed as a proposed biosimilar to eculizumab reference product (RP), a humanized monoclonal antibody (IgG2/4 kappa...
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Knowledge of genetics and attitudes toward genetic testing among university students in Indonesia
The development in human genetics must be tracked with the knowledge to provide support and positive attitudes towards genetic research and its...
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Replacement of animal testing by integrated approaches to testing and assessment (IATA): a call for in vivitrosi
Alternative methods to animal use in toxicology are evolving with new advanced tools and multilevel approaches, to answer from one side to 3Rs...
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The Influence of Headform Friction and Inertial Properties on Oblique Impact Helmet Testing
Helmet-testing headforms replicate the human head impact response, allowing the assessment of helmet protection and injury risk. However, the...
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DNA Testing, Genetics and Identity
In the first part of this chapter, the basic DNA testing method employed in establishing identity is described (using PCR amplification of variable...
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Abdominal vessel segmentation using vessel model embedded fuzzy C-means and similarity from CT angiography
AbstractThe accurate abdominal vessel segmentation of CT angiography (CTA) data is essential for diagnosis and surgical planning. However, accurate...
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A humanized minipig model for the toxicological testing of therapeutic recombinant antibodies
The safety of most human recombinant proteins can be evaluated in transgenic mice tolerant to specific human proteins. However, owing to insufficient...
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Secondary use of genomic data: patients’ decisions at point of testing and perspectives to inform international data sharing
International sharing of genomic data files arising from clinical testing of patients is essential to further improve genomic medicine. Whilst the...
