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Introduction of Cancer Education Program in Secondary School Curriculum: Perceptions of Education Teachers and Policymakers in Oman
The prevalence of cancer is expected to increase worldwide for reasons related to a lack of awareness of cancer prevention, diagnosis, and treatment....
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Exploring smoking cessation experiences among persons with spinal cord injury: Informing theory-based recommendations for interventions
Study designQualitative study.
ObjectiveUse an integrated knowledge translation (IKT) and theory-based approach, to (1) explore factors influencing...
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Pharmacogenetics in Epilepsy and Refractory Epilepsy
Pharmacogenomic studies in epilepsy are necessary due to the high prevalence of this disease and the high percentage of drug resistance phenotype....
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Acupuncture for Counteracting P2X4 and P2X7 Receptor Involvement in Neuroinflammation
Neuroinflammation refers to an inflammatory change within the brain or spinal cord, mainly characterized by the activation/invasion of the following...
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Main Biochemical Aspects of the Pathogenesis of Depression. Part II
This article discusses studies of the pathophysiological bases of the depressive state reflecting the significance of the third component of signal...
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Involvement of redox signalling in tumour cell dormancy and metastasis
Decades of research on oncogene-driven carcinogenesis and gene-expression regulatory networks only started to unveil the complexity of tumour...
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Endolichenic Fungi, an Emerging Source of Bioactive Compounds: A Pharmaceutical Perspective
Endolichenic fungi (ELF), residing within the thallus of lichen, which is a symbiotic association of algae and fungi, are emerging as an alternative...
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Targeting memory loss with aspirin, a molecular mechanism perspective for future therapeutic approaches
Acetylsalicylic acid (ASA), also known as aspirin, was discovered in 1897 as an acetylated form of salicylate. It has been widely used for its...
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Impact of Oxidative Stress on Embryogenesis and Fetal Development
Multiple cellular processes are regulated by oxygen radicals or reactive oxygen species (ROS) where they play crucial roles as primary or secondary...
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Purinergic Signaling in Autism Spectrum Disorder
Autism spectrum disorder (ASD) is a highly prevalent neurodevelopmental disorder estimated to affect 1:36 individuals, characterized by impairments...
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Clinical Approaches in Targeting ROS-Induced Cancer
Reactive oxygen species (ROS) results from various metabolic processes and plays a significant role as secondary messengers across multiple signaling...
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Clinical Approaches in Targeting ROS-Induced Cancer
Reactive oxygen species (ROS) results from various metabolic processes and plays a significant role as secondary messengers across multiple signaling...
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Phosphoinositide acyl chain saturation drives CD8+ effector T cell signaling and function
How lipidome changes support CD8 + effector T (T eff ) cell differentiation is not well understood. Here we show that, although naive T cells are rich...
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Plant-Derived Extracellular Nanovesicles for Disease Therapy
Natural plants and traditional Chinese medicines (TCMs) have been widely used throughout human history and are available in many pharmaceutical...
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Microbial Interventions to Induce Secondary Metabolite Biosynthesis in Medicinal and Aromatic Plants
Medicinal and aromatic plants (MAPs) are well known to produce a plethora of secondary metabolites that are important class of phytochemicals...
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Spinal cord stimulation for neuropathic pain following traumatic spinal cord injury: a case report
IntroductionNeuropathic pain is a common complication of spinal cord injury (SCI), and is notoriously difficult to adequately treat. Gunshot wounds...
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Activation of aryl hydrocarbon receptor (AhR) in Alzheimer’s disease: role of tryptophan metabolites generated by gut host-microbiota
AbstractGut microbiota in interaction with intestinal host tissues influences many brain functions and microbial dysbiosis has been linked with brain...
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Pharmacological Targets and Mechanisms of Action of Antipsychotic Substances in the Context of the Neurochemical Theory of the Pathogenesis of Schizophrenia
Schizophrenia is characterized by neurochemical, morphological, bioelectrical, and behavioral changes in the body, which overall produce a system of...
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A Trichinella spiralis new born larvae-specific protein, Ts-NBL1, interacts with host’s cell vimentin
The parasitic nematode Trichinella has a special relationship with its host as it has a unique intracellular location within the feeder cell which is...
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Satellite Glial Cells and Astrocytes, a Comparative Review
Astroglia are neural cells, heterogeneous in form and function, which act as supportive elements of the central nervous system; astrocytes contribute...
