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Biomedicine

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Showing 1-9 of 9 results

  1. Nonsteroidal Anti-Inflammatory Drug Leads from Plant Sources

    Nonsteroidal anti-inflammatory drugs are FDA-approved for their anti-inflammatory, antipyretic (fever-reducing), and analgesic (pain-relieving)...
    Sharanya C S, Kathiresan Natarajan in Drugs from Nature: Targets, Assay Systems and Leads
    Chapter 2024

  2. Pharmacokinetics and extensive intestinal first-pass effects of apigenin and its active metabolite, apigenin-7-O-glucuronide, in rats

    Purpose

    This study investigated the metabolism and pharmacokinetics of apigenin and its metabolite, apigenin-7- O -glucuronide (A7G), using a newly...

    Seong-Wook Seo, Soon Ho Choi, ... In-Soo Yoon in Journal of Pharmaceutical Investigation
    Article 17 February 2024

  3. Quercetin-Loaded Nanomedicine as Oncotherapy

    Phytochemicals as nutritional components have been explored for their anticancer properties. Quercetin (QT), being a chief component of different...
    Sabya Sachi Das, P. R. P. Verma, ... Sandeep Kumar Singh in Nanomedicine for Bioactives
    Chapter 2020

  4. Computational Design of Multitarget Drugs Against Alzheimer’s Disease

    In the present review, the authors provide the basic background about the molecular targets implicated in the pathogenesis of Alzheimer’s disease....
    Sotirios Katsamakas, Dimitra Hadjipavlou-Litina in Multi-Target Drug Design Using Chem-Bioinformatic Approaches
    Protocol 2018

  5. Role of Plant Polyphenols in Alzheimer’s Disease

    Alzheimer’s disease (AD) is the most common neurodegenerative disease, characterized by notable memory loss, cognitive impairment, and personality...
    Arokiasamy Justin Thenmozhi, Thamilarasan Manivasagam, Musthafa Mohamed Essa in The Benefits of Natural Products for Neurodegenerative Diseases
    Chapter 2016

  6. Two- and three-dimensional quantitative structure–permeability relationship of flavonoids in Caco-2 cells using stepwise multiple linear regression (SMLR), partial least squares regression (PLSR), and pharmacophore (GALAHAD)-based comparative molecular similarity index analysis (COMSIA)

    Abstract

    Limited oral bioavailability has hindered the widespread use of flavonoids as bioactive substances. Several studies have been performed to...

    Gerard Bryan Gonzales, John Van Camp, ... Guy Smagghe in Medicinal Chemistry Research
    Article 10 September 2014

  7. Pharmacogenomics of Alzheimer’s Disease: Novel Therapeutic Strategies for Drug Development

    Alzheimer’s disease (AD) is a major problem of health and disability, with a relevant economic impact on our society. Despite important advances in...
    Ramón Cacabelos, Pablo Cacabelos, ... Juan C. Carril in Pharmacogenomics in Drug Discovery and Development
    Protocol 2014

  8. Extraction and Isolation of Phenolic Compounds

    Phenolic compounds constitute a major class of plant secondary metabolites that are widely distributed in the plant kingdom and show a large...
    Celestino Santos-Buelga, Susana Gonzalez-Manzano, ... Ana M. Gonzalez-Paramas in Natural Products Isolation
    Protocol 2012

  9. Pharmacokinetics of scutellarin and its aglycone conjugated metabolites in rats

    Scutellarin, a flavonoid glycoside, is the primary active ingredient in breviscapine that is a mixture of flavonoid glycosides extracted from a...

    J. M. Huang, W. Y. Weng, ... E. Chen in European Journal of Drug Metabolism and Pharmacokinetics
    Article 01 September 2005
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