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Replication-competent HIV-1 in human alveolar macrophages and monocytes despite nucleotide pools with elevated dUTP
BackgroundAlthough CD4 + memory T cells are considered the primary latent reservoir for HIV-1, replication competent HIV has been detected in tissue...
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Pseudotyped Viruses
Pseudotyped viruses have been constructed for many viruses. They can mimic the authentic virus and have many advantages compared to authentic...
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A qPCR-Based Method for Quantification of Replication Competent Adenovirus (RCA) in Conditionally Replicating Oncolytic Adenoviruses
Production of conditionally replicating adenoviruses may unfortunately generate undesired replication-competent adenovirus (RCA) which raises safety...
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A single dose of replication-competent VSV-vectored vaccine expressing SARS-CoV-2 S1 protects against virus replication in a hamster model of severe COVID-19
The development of effective countermeasures against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the agent responsible for the...
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Pseudotyped Viruses for Orthohantavirus
Orthohantaviruses, members of the Orthohantavirus genus of Hantaviridae family of the Bunyavirales order, are enveloped, negative-sense,...
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Analysis of PERV-C superinfection resistance using HA-tagged viruses
BackgroundUsing pigs as organ donors has advanced xenotransplantation to the point that it is almost ready for clinical use. However, there is still...
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Replicating-Competent VSV-Vectored Pseudotyped Viruses
Vesicular stomatitis virus (VSV) is prototype virus in the family of Rhabdoviridae. Reverse genetic platform has enabled the genetic manipulation of...
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Pseudotyped Viruses for Marburgvirus and Ebolavirus
Marburg virus (MARV) and Ebola virus (EBOV) of the Filoviridae family are the most lethal viruses in terms of mortality rate. However, the...
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Pseudotyped Viruses for Influenza
We have developed an influenza hemagglutinin (HA) pseudotype (PV) library encompassing all influenza A (IAV) subtypes from HA1-HA18, influenza B...
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Type I Interferon: Monkeypox/Mpox Viruses Achilles Heel?
Poxviruses are notorious for having acquired/evolved numerous genes to counteract host innate immunity. Chordopoxviruses have acquired/evolved at...
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Isolation and evaluation of antiviral plant compounds against respiratory disease-causing viruses: a review
Influenza viruses are major concern worldwide due to their fast ability to spread, and causing the respiratory illness of varying severity. The rate...
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Structural Alterations in Non-enveloped Viruses During Disassembly
The capsid shells of non-enveloped virusesNon-enveloped viruses can be categorized as large macromolecules constituted from protein building blocks,...
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Multivalent viral particles elicit safe and efficient immunoprotection against Nipah Hendra and Ebola viruses
Experimental vaccines for the deadly zoonotic Nipah (NiV), Hendra (HeV), and Ebola (EBOV) viruses have focused on targeting individual viruses,...
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Identification of small circular DNA viruses in coyote fecal samples from Arizona (USA)
Coyotes ( Canis latrans ) have a broad geographic distribution across North and Central America. Despite their widespread presence in urban...
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The interactions between PML nuclear bodies and small and medium size DNA viruses
Promyelocytic leukemia nuclear bodies (PM NBs), often referred to as membraneless organelles, are dynamic macromolecular protein complexes composed...
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Receptor-Binding Specificity of Influenza Viruses
Influenza A virus infection begins with the attachment of virus particles to sialic acid-containing receptors on the surface of host cells. This...
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Exploring the link between viruses and cancer in companion animals: a comprehensive and comparative analysis
Currently, it is estimated that 15% of human neoplasms globally are caused by infectious agents, with new evidence emerging continuously. Multiple...
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Temperature affects viral kinetics and vectorial capacity of Aedes aegypti mosquitoes co-infected with Mayaro and Dengue viruses
BackgroundIncreasing global temperatures and unpredictable climatic extremes have contributed to the spread of vector-borne diseases. The mosquito Aed...
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Pseudotyped Viruses for Retroviruses
Since the discovery of retroviruses, their genome and replication strategies have been extensively studied, leading to the discovery of several...
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Oncolytic Viruses and Viral Gene Therapy Vectors: Principles of Safety
With the emergence of genetic engineering, a new era of viral safety was introduced. Apart from the means to attenuate classical viral vaccines, new...