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  1. Neural Repair Methods and Protocols

    This detailed collection explores a diverse range of topics related to neural repair and functional recovery following ischemic stroke. Techniques...
    Vardan T. Karamyan, Ann M. Stowe in Methods in Molecular Biology
    Book 2023
  2. DNA Damage and DNA Repair

    This chapter describes in more detail the various kinds of DNA damage that can cause mutations and chromosomal alterations as well as the...
    Wolfgang A. Schulz in Molecular Biology of Human Cancers
    Chapter 2023
  3. DNA Repair

    Reference work entry 2024
  4. Roles of NRF2 in DNA damage repair

    Purpose

    The transcription factor NF-E2-related factor 2 (NRF2) is a master regulator widely involved in essential cellular functions such as DNA...

    Jiale Li, Chang Xu, Qiang Liu in Cellular Oncology
    Article 26 June 2023
  5. Molecular and Regenerative Characterization of Repair and Non-repair Schwann Cells

    Although evidence has accumulated to indicate that Schwann cells (SCs) differentiate into repair SCs (RSCs) upon injury and that the unique phenotype...

    Tomoaki Suzuki, Ken Kadoya, ... Norimasa Iwasaki in Cellular and Molecular Neurobiology
    Article 12 October 2022
  6. Role of Inflammation in Tissue Regeneration and Repair

    Inflammation plays critical roles in tissue repair and regeneration. After tissue injury, inflammatory immune cells are recruited to the wound site,...
    Sheetal Saini, Prankrishna Kakati, Kulwant Singh in Inflammation Resolution and Chronic Diseases
    Chapter 2024
  7. Myocardial Tissue Repair and Regeneration

    Heart failure caused by myocardial infarction (MI) remains a major threat to human health. After MI, a series of pathological events take place,...
    Kai Wang, Shuqin Wang, ... Changyou Gao in Polymeric Biomaterials for Tissue Regeneration
    Chapter 2023
  8. Comparison of comet-based approaches to assess base excision repair

    DNA repair plays an essential role in maintaining genomic stability, and can be assessed by various comet assay-based approaches, including the...

    Congying Zheng, Sergey Shaposhnikov, ... Roger Godschalk in Archives of Toxicology
    Article Open access 22 June 2023
  9. MRE11 lactylation: new insight into DNA damage repair and tumorigenesis

    The increased accumulation of lactate in tumor microenvironment is a characteristic feature of tumorigenesis, which affects various biological...

    Hui Yang, **qin Qian, ... Wei-Guo Zhu in Genome Instability & Disease
    Article 22 January 2024
  10. A spatiotemporal atlas of cholestatic injury and repair in mice

    Cholestatic liver injuries, characterized by regional damage around the bile ductular region, lack curative therapies and cause considerable...

    Baihua Wu, **nyi Shentu, ... Lijian Hui in Nature Genetics
    Article 16 April 2024
  11. Delay modulates the immune response to nerve repair

    Effective regeneration after peripheral nerve injury requires macrophage recruitment. We investigated the activation of remodeling pathways within...

    Masoud Golshadi, Elaine F. Claffey, ... Jonathan Cheetham in npj Regenerative Medicine
    Article Open access 27 February 2023
  12. Bleomycin induces senescence and repression of DNA repair via downregulation of Rad51

    Background

    Bleomycin, a potent antitumor agent, is limited in clinical use due to the potential for fatal pulmonary toxicity. The accelerated DNA...

    Fuqiang Chen, Wenna Zhao, ... Meijuan Zhou in Molecular Medicine
    Article Open access 22 April 2024
  13. X-ray cross-complementing family: the bridge linking DNA damage repair and cancer

    Genomic instability is a common hallmark of human tumours. As a carrier of genetic information, DNA is constantly threatened by various damaging...

    Qiang Liu, Qiu Peng, ... Yueqiu Tan in Journal of Translational Medicine
    Article Open access 07 September 2023
  14. Initiating and Facilitating Brain Repair: Factors, Principles, and Mechanisms

    Introduction: Acute injuries to the brain result in a wide range of sequelae, and several factors contribute to the severity of a brain lesion,...
    Laura N. Zamproni, Marimelia A. Porcionatto in Regenerative Medicine and Brain Repair
    Chapter 2024
  15. Chemotherapy-induced neuronal DNA damage: an intriguing toolbox to elucidate DNA repair mechanisms in the brain

    The accumulation of DNA damage and subsequent decline in cellular functions are significant factors contributing to aging and-age associated...

    Aishwarya Babu, Madhusoodanan Urulangodi in Genome Instability & Disease
    Article 06 November 2023
  16. DNA repair in tumor radioresistance: insights from fruit flies genetics

    Background

    Radiation therapy (RT) is a key anti-cancer treatment that involves using ionizing radiation to kill tumor cells. However, this therapy can...

    Antonella Porrazzo, Matteo Cassandri, ... Giovanni Cenci in Cellular Oncology
    Article 14 December 2023
  17. Mini-MEndR: a miniaturized 96-well predictive assay to evaluate muscle stem cell-mediated repair

    Background

    Functional evaluation of molecules that are predicted to promote stem cell mediated endogenous repair often requires in vivo transplant...

    Nitya Gulati, Sadegh Davoudi, ... Penney M. Gilbert in BMC Methods
    Article Open access 07 June 2024
  18. Single-Cell Transcriptomics Revealed White Matter Repair Following Subarachnoid Hemorrhage

    Existing research indicates the potential for white matter injury repair during the subacute phase following subarachnoid hemorrhage (SAH). However,...

    **ng Wang, Dingke Wen, ... Lu Ma in Translational Stroke Research
    Article 11 June 2024
  19. PDHE1α in DNA damage repair: a critical chromatin acetylation regulator

    A recent study in Nature Structural and Molecular Biology reveals that chromatin-associated PDHE1α generates acetyl-CoA near DNA double-strand...

    Bingsong Huang, Yu** Chen, Jian Yuan in Genome Instability & Disease
    Article 11 November 2023
  20. miRNAs contributing to the repair of tendon injury

    Tendon injury is one of the most common disorders of the musculoskeletal system, with a higher likelihood of occurrence in elderly individuals and...

    Kexin Lyu, **nyue Liu, ... Sen Li in Cell and Tissue Research
    Article Open access 30 May 2023
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