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Neural Repair Methods and Protocols
This detailed collection explores a diverse range of topics related to neural repair and functional recovery following ischemic stroke. Techniques... -
DNA Damage and DNA Repair
This chapter describes in more detail the various kinds of DNA damage that can cause mutations and chromosomal alterations as well as the... -
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Roles of NRF2 in DNA damage repair
PurposeThe transcription factor NF-E2-related factor 2 (NRF2) is a master regulator widely involved in essential cellular functions such as DNA...
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Molecular and Regenerative Characterization of Repair and Non-repair Schwann Cells
Although evidence has accumulated to indicate that Schwann cells (SCs) differentiate into repair SCs (RSCs) upon injury and that the unique phenotype...
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Role of Inflammation in Tissue Regeneration and Repair
Inflammation plays critical roles in tissue repair and regeneration. After tissue injury, inflammatory immune cells are recruited to the wound site,... -
Myocardial Tissue Repair and Regeneration
Heart failure caused by myocardial infarction (MI) remains a major threat to human health. After MI, a series of pathological events take place,... -
Comparison of comet-based approaches to assess base excision repair
DNA repair plays an essential role in maintaining genomic stability, and can be assessed by various comet assay-based approaches, including the...
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MRE11 lactylation: new insight into DNA damage repair and tumorigenesis
The increased accumulation of lactate in tumor microenvironment is a characteristic feature of tumorigenesis, which affects various biological...
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A spatiotemporal atlas of cholestatic injury and repair in mice
Cholestatic liver injuries, characterized by regional damage around the bile ductular region, lack curative therapies and cause considerable...
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Delay modulates the immune response to nerve repair
Effective regeneration after peripheral nerve injury requires macrophage recruitment. We investigated the activation of remodeling pathways within...
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Bleomycin induces senescence and repression of DNA repair via downregulation of Rad51
BackgroundBleomycin, a potent antitumor agent, is limited in clinical use due to the potential for fatal pulmonary toxicity. The accelerated DNA...
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X-ray cross-complementing family: the bridge linking DNA damage repair and cancer
Genomic instability is a common hallmark of human tumours. As a carrier of genetic information, DNA is constantly threatened by various damaging...
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Initiating and Facilitating Brain Repair: Factors, Principles, and Mechanisms
Introduction: Acute injuries to the brain result in a wide range of sequelae, and several factors contribute to the severity of a brain lesion,... -
Chemotherapy-induced neuronal DNA damage: an intriguing toolbox to elucidate DNA repair mechanisms in the brain
The accumulation of DNA damage and subsequent decline in cellular functions are significant factors contributing to aging and-age associated...
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DNA repair in tumor radioresistance: insights from fruit flies genetics
BackgroundRadiation therapy (RT) is a key anti-cancer treatment that involves using ionizing radiation to kill tumor cells. However, this therapy can...
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Mini-MEndR: a miniaturized 96-well predictive assay to evaluate muscle stem cell-mediated repair
BackgroundFunctional evaluation of molecules that are predicted to promote stem cell mediated endogenous repair often requires in vivo transplant...
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Single-Cell Transcriptomics Revealed White Matter Repair Following Subarachnoid Hemorrhage
Existing research indicates the potential for white matter injury repair during the subacute phase following subarachnoid hemorrhage (SAH). However,...
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PDHE1α in DNA damage repair: a critical chromatin acetylation regulator
A recent study in Nature Structural and Molecular Biology reveals that chromatin-associated PDHE1α generates acetyl-CoA near DNA double-strand...
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miRNAs contributing to the repair of tendon injury
Tendon injury is one of the most common disorders of the musculoskeletal system, with a higher likelihood of occurrence in elderly individuals and...