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Phosphorylation and oligomerization of α-synuclein associated with GSK-3β activation in the rTg4510 mouse model of tauopathy
Neurodegenerative diseases are characterized by the accumulation of specific phosphorylated protein aggregates in the brain, such as...
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Assessment of the In Vivo Relationship Between Cerebral Hypometabolism, Tau Deposition, TSPO Expression, and Synaptic Density in a Tauopathy Mouse Model: a Multi-tracer PET Study
Cerebral glucose hypometabolism is a typical hallmark of Alzheimer’s disease (AD), usually associated with ongoing neurodegeneration and neuronal...
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Enhancement of tripartite synapses as a potential therapeutic strategy for Alzheimer’s disease: a preclinical study in rTg4510 mice
BackgroundThe lack of effective treatment options for Alzheimer’s disease (AD) is of momentous societal concern. Synaptic loss is the hallmark of AD...
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FKBP52 overexpression accelerates hippocampal-dependent memory impairments in a tau transgenic mouse model
Abnormal accumulation of hyperphosphorylated tau induces pathogenesis in neurodegenerative diseases, like Alzheimer’s disease. Molecular chaperones...
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Microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of Alzheimer’s disease
Microglia-mediated neuroinflammation has been implicated in the pathogenesis of Alzheimer’s disease (AD). Although microglia in aging and...
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Tau reduction in aged mice does not impact Microangiopathy
Microangiopathy, including proliferation of small diameter capillaries, increasing vessel tortuosity, and increased capillary blockage by leukocytes,...
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Longitudinal changes in EEG power, sleep cycles and behaviour in a tau model of neurodegeneration
BackgroundDisturbed sleep is associated with cognitive decline in neurodegenerative diseases such as Alzheimer’s disease (AD) and frontotemporal...
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SETD7-mediated monomethylation is enriched on soluble Tau in Alzheimer’s disease
BackgroundHuman tauopathies including Alzheimer’s disease (AD) are characterized by alterations in the post-translational modification (PTM) pattern...
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Novel alterations in corneal neuroimmune phenotypes in mice with central nervous system tauopathy
BackgroundTauopathy in the central nervous system (CNS) is a histopathological hallmark of frontotemporal dementia (FTD) and Alzheimer’s disease...
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Genome-wide RNAseq study of the molecular mechanisms underlying microglia activation in response to pathological tau perturbation in the rTg4510 tau transgenic animal model
BackgroundActivation of microglia, the resident immune cells of the central nervous system, is a prominent pathological hallmark of Alzheimer’s...
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Near-infrared fluorescence lifetime imaging of amyloid-β aggregates and tau fibrils through the intact skull of mice
Non-invasive methods for the in vivo detection of hallmarks of Alzheimer’s disease can facilitate the study of the progression of the disease in...
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Neuroinflammation in Alzheimer’s disease: microglial signature and their relevance to disease
Alzheimer’s disease (AD) is the most common form of dementia, pathologically characterized by senile plaques and neurofibrillary tangles (NFTs),...
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Updates on mouse models of Alzheimer’s disease
Alzheimer’s disease (AD) is the most common neurodegenerative disease in the United States (US). Animal models, specifically mouse models have been...
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Optic nerve thinning and neurosensory retinal degeneration in the rTg4510 mouse model of frontotemporal dementia
Visual impairments, such as difficulties in reading and finding objects, perceiving depth and structure from motion, and impaired stereopsis, have...
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Sha** the future of preclinical development of successful disease-modifying drugs against Alzheimer's disease: a systematic review of tau propagation models
The transcellular propagation of the aberrantly modified protein tau along the functional brain network is a key hallmark of Alzheimer's disease and...
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Intracerebral Expression of AAV-APOE4 Is Not Sufficient to Alter Tau Burden in Two Distinct Models of Tauopathy
Apolipoprotein E4 ( APOE4 ) is the major genetic risk factor for sporadic Alzheimer's disease (AD), which is characterized by amyloid β (Aβ) plaques...
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Tau interactome and RNA binding proteins in neurodegenerative diseases
Pathological tau aggregation is a primary neuropathological feature of many neurodegenerative diseases. Intriguingly, despite the common presence of...
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A novel transgenic mouse line with hippocampus-dominant and inducible expression of truncated human tau
BackgroundIntraneuronal accumulation of hyperphosphorylated tau is a defining hallmark of Alzheimer’s disease (AD). However, mouse models imitating...
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Tau Ser208 phosphorylation promotes aggregation and reveals neuropathologic diversity in Alzheimer’s disease and other tauopathies
Tau protein abnormally aggregates in tauopathies, a diverse group of neurologic diseases that includes Alzheimer’s disease (AD). In early stages of...
