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Juckreiz (Pruritus)
Pruritus, auch Juckreiz genannt, ist ein irritierendes Gefühl auf der Hautoberfläche, das vermutlich durch die Stimulation von sensorischen...
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Anti-pruritic effect of L-carnitine against chloroquine-induced pruritus mediated via nitric oxide pathway
BackgroundPruritus, or itching, is a distressing symptom associated with various dermatological and systemic diseases. L-carnitine (βeta...
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Curcumin inhibits the pruritus in mice through mast cell MrgprB2 receptor
BackgroundCurcumin is a diketone compound extracted from the rhizomes of some plants in the Zingiberaceae and Araceae family. It possesses a variety...
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Imiquimod-induced pruritus in female wild-type and knockin Wistar rats: underscoring behavioral scratching in a rat model for antipruritic treatments
ObjectivesAnimal models of skin disease are used to evaluate therapeutics to alleviate disease. One common clinical dermatological complaint is...
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Inhibitory Effects of Euscaphic Acid in the Atopic Dermatitis Model by Reducing Skin Inflammation and Intense Pruritus
Atopic dermatitis (AD) is a complex and multifactorial skin disease characterized by skin inflammation and intense pruritus. There are many...
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Pruritus
Pruritus, also called itching, is an irritating sensation in the upper surface of the skin, thought to result from stimulation of sensory nerve...
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Interleukin-31, a Potent Pruritus-Inducing Cytokine and Its Role in Inflammatory Disease and in the Tumor Microenvironment
Substantial new information has emerged supporting the fundamental role of the cytokine interleukin-31 (IL-31) in the genesis of chronic pruritus in...
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The lateral habenula nucleus regulates pruritic sensation and emotion
Itch is a complex aversive sensory and emotional experience. As a most upsetting symptom in many dermatological and systemic diseases, it lacks...
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Case series of reports of pruritus and sipuleucel-T submitted to the Food and Drug Administration Adverse Event Reporting System
Sipuleucel-T, an autologous active cellular immunotherapy, is indicated for the treatment of asymptomatic or minimally symptomatic...
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Clinical Profiles of Nalfurafine Hydrochloride for the Treatment of Pruritus Patients
Nalfurafine hydrochloride is a selective kappa-opioid agonist that has antipruritic effects. Here we describe the clinical trials for treatment of...
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A systematic review of interleukin-31 inhibitors in the treatment of prurigo nodularis
BackgroundPrurigo nodularis (PN) is a neuroimmunological skin disease. Severe itching is the most challenging symptom which affects patients’ quality...
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Clarifying sleep characteristics and analyzing risk factors of sleep disorders to promote a predictive, preventive, and personalized medicine in patients with burn scars
PurposeThis study assessed sleep quality in patients with burn scars and investigated risk factors of sleep disorders to guide clinical therapy. From...
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Pruritus Characteristics in Severe Atopic Dermatitis in Adult Patients
Atopic dermatitis (AD) is classified as a most common inflammatory skin disease. The condition is characterized by recurrent eczematous lesions and...
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Clear cell sarcoma of the kidney in a 62-year-old patient presenting with generalized pruritus
BackgroundClear cell sarcoma of the kidney (CCSK) is the second most common renal tumor in children following Wilms’ tumor. CCSK is extremely rare in...
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Common Scabies and Special Presentations
Common scabies manifests as pruritus and erythematous to hyperpigmented papules typically affecting the interdigital webspaces, hands, volar wrists,...
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Management of Common Scabies
The management of common scabies infestation has pharmacologic and non-pharmacologic elements. Pharmacologic intervention consists of anti-parasitic...
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STING controls opioid-induced itch and chronic itch via spinal tank-binding kinase 1-dependent type I interferon response in mice
BackgroundPatients receiving epidural or intrathecal opioids administration for neuraxial analgesia frequently suffer from an irritating itch. STING...
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Tropifexor for nonalcoholic steatohepatitis: an adaptive, randomized, placebo-controlled phase 2a/b trial
The multimodal activities of farnesoid X receptor (FXR) agonists make this class an attractive option to treat nonalcoholic steatohepatitis. The...
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Pharmacological update of mirtazapine: a narrative literature review
Mirtazapine (MTZ) is an antidepressant drug with an exceptional pharmacological profile. It also has an excellent safety and tolerability profile....
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Sarcoptes scabiei infestation in a captive lowland tapir (Tapirus terrestris): case report, morphological and molecular genetic mite identification
Sarcoptes scabiei (Acari: Sarcoptidae) is a globally distributed parasitic mite species, which causes mange in a broad spectrum of domestic and wild...
