Search
Search Results
-
-
ACE2 in chronic disease and COVID-19: gene regulation and post-translational modification
Angiotensin-converting enzyme 2 (ACE2), a counter regulator of the renin-angiotensin system, provides protection against several chronic diseases....
-
Post-translational protein lactylation modification in health and diseases: a double-edged sword
As more is learned about lactate, it acts as both a product and a substrate and functions as a shuttle system between different cell populations to...
-
Therapeutic Implications and Regulations of Protein Post-translational Modifications in Parkinsons Disease
Parkinsons disease (PD) is a neurodegenerative disorder characterized by dopaminergic neuron loss and alpha-synuclein aggregation. This comprehensive...
-
Complicated Role of Post-translational Modification and Protease-Cleaved Fragments of Tau in Alzheimer’s Disease and Other Tauopathies
Tau, a microtubule-associated protein predominantly localized in neuronal axons, plays a crucial role in promoting microtubule assembly, stabilizing...
-
Roles of protein post-translational modifications in glucose and lipid metabolism: mechanisms and perspectives
The metabolism of glucose and lipids is essential for energy production in the body, and dysregulation of the metabolic pathways of these molecules...
-
Aberrant accumulation of NIK promotes tumor growth by dysregulating translation and post-translational modifications in breast cancer
BackgroundIn vivo investigations with cancer cells have powerful tools to discover cancer progression mechanisms and preclinical candidate drugs....
-
Post-translational modifications on the retinoblastoma protein
The retinoblastoma protein (pRb) functions as a cell cycle regulator controlling G1 to S phase transition and plays critical roles in tumour...
-
Prominent astrocytic alpha-synuclein pathology with unique post-translational modification signatures unveiled across Lewy body disorders
Alpha-synuclein (aSyn) is a pre-synaptic monomeric protein that can form aggregates in neurons in Parkinson’s disease (PD), Parkinson’s disease with...
-
Pathways in Human Arrhythmias: Impact of Post-translational Modifications
The cardiac proteome has a vast number of gene products that are post-translationally modified (PTM). PTMs are essential for the regulation of normal...
-
Transcriptional regulation and post-translational modifications in the glycolytic pathway for targeted cancer therapy
Cancer cells largely rely on aerobic glycolysis or the Warburg effect to generate essential biomolecules and energy for their rapid growth. The key...
-
Role of non-canonical post-translational modifications in gastrointestinal tumors
Post-translational modifications (PTMs) of proteins contribute to the occurrence and development of tumors. Previous studies have suggested that...
-
Intricate effects of post-translational modifications in liver cancer: mechanisms to clinical applications
Liver cancer is a significant global health challenge, with hepatocellular carcinoma (HCC) being the most prevalent form, characterized by high...
-
O-GlcNAcylation: an important post-translational modification and a potential therapeutic target for cancer therapy
O -linked β- d - N -acetylglucosamine ( O -GlcNAc) is an important post-translational modification of serine or threonine residues on thousands of proteins...
-
The Role of Post-Translational Modifications on the Structure and Function of Tau Protein
Involving addition of chemical groups or protein units to specific residues of the target protein, post-translational modifications (PTMs) alter the...
-
Protein post-translational modifications in the regulation of cancer hallmarks
Posttranslational modifications (PTMs) of proteins, the major mechanism of protein function regulation, play important roles in regulating a variety...
-
Proteomic characterization of post-translational modifications in drug discovery
Protein post-translational modifications (PTMs), which are usually enzymatically catalyzed, are major regulators of protein activity and involved in...
-
Novel histone post-translational modifications in Alzheimer’s disease: current advances and implications
Alzheimer’s disease (AD) has a complex pathogenesis, and multiple studies have indicated that histone post-translational modifications, especially...
-
Regulation of tumor metabolism by post translational modifications on metabolic enzymes
Metabolic reprogramming is a hallmark of cancer development, progression, and metastasis. Several metabolic pathways such as glycolysis,...
-
Proteomic analysis of lysine 2-hydroxyisobutyryl in SLE reveals protein modification alteration in complement and coagulation cascades and platelet activation Pathways
BackgroundPost-translational modifications (PTMs) are considered to be an important factor in the pathogenesis of Systemic lupus erythematosus (SLE)....
