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Ubiquitin–Proteasome System as a Potential Drug Target for Malaria
The ubiquitin–proteasome system is an essential protein degradation machinery responsible for maintaining cellular protein homeostasis. It is a...
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Zonisamide attenuates pressure overload-induced myocardial hypertrophy in mice through proteasome inhibition
Myocardial hypertrophy is a pathological thickening of the myocardium which ultimately results in heart failure. We previously reported that...
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Proteasome-Associated Syndromes: Updates on Genetics, Clinical Manifestations, Pathogenesis, and Treatment
The ubiquitin–proteasome system (UPS) has a critical role in post-translational protein modification that is essential for the maintenance of all...
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The Ubiquitin–Proteasome System and Cerebellar Developmental Disease
A variety of developmental diseases of the cerebellum are associated with the dysregulation of proteins regulated by the ubiquitin–proteasome system...
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Tetramethylpyrazine Nitrone Promotes the Clearance of Alpha-Synuclein via Nrf2-Mediated Ubiquitin–Proteasome System Activation
Aggregation of α-synuclein (α-syn) and α-syn cytotoxicity are hallmarks of sporadic and familial Parkinson’s disease (PD). Nuclear factor...
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Clinically relevant stratification of lung squamous carcinoma patients based on ubiquitinated proteasome genes for 3P medical approach
RelevanceThe proteasome is a crucial mechanism that regulates protein fate and eliminates misfolded proteins, playing a significant role in cellular...
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Dysregulated proteasome activity and steroid hormone biosynthesis are associated with mortality among patients with acute COVID-19
The persistence of coronavirus disease 2019 (COVID-19)-related hospitalization severely threatens medical systems worldwide and has increased the...
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Interplay between proteasome function and inflammatory responses in e-cig vapor condensate-challenged lung epithelial cells
Exposure to cigarettes and other nicotine-based products results in persistent inflammation in the lung. In recent years, electronic cigarettes...
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Fibroblast growth factor-21 alleviates proteasome injury via activation of autophagy flux in Parkinson’s disease
Parkinson’s disease (PD) is one of the most common and complex Neurodegeneration, with an inherited metabolic disorder. Fibroblast growth factor 21...
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Inhibition of the Proteasome Regulator PA28 Aggravates Oxidized Protein Overload in the Diabetic Rat Brain
Oxidized protein overloading caused by diabetes is one accelerating pathological pathway in diabetic encephalopathy development. To determine whether...
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Immune escape of multiple myeloma cells results from low miR29b and the ensuing epigenetic silencing of proteasome genes
BackgroundActivation of CD28 on multiple myeloma (MM) plasma cells, by binding to CD80 and CD86 on dendritic cells, decreases proteasome subunit...
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Proteasome inhibition protects blood–brain barrier P-glycoprotein and lowers Aβ brain levels in an Alzheimer’s disease model
BackgroundLoss of P-glycoprotein (P-gp) at the blood–brain barrier contributes to amyloid-β (Aβ) brain accumulation in Alzheimer’s disease (AD)....
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Molecular Cardiotoxic Effects of Proteasome Inhibitors Carfilzomib and Ixazomib and Their Combination with Dexamethasone Involve Mitochondrial Dysregulation
With the development and approval of new proteasome inhibitors, proteasome inhibition is increasingly recognized in cancer therapy. Besides...
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The Ubiquitin Proteasome System as a Therapeutic Area in Parkinson’s Disease
Parkinson’s disease (PD) is the most common neurodegenerative movement disorder. There are no available therapeutics that slow or halt the...
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The Role of Ubiquitin–Proteasome System and Mitophagy in the Pathogenesis of Parkinson's Disease
Parkinson's disease (PD) is a common neurodegenerative disease that is mainly in middle-aged people and elderly people, and the pathogenesis of PD is...
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Clonal heterogeneity in ER+ breast cancer reveals the proteasome and PKC as potential therapeutic targets
Intratumoral heterogeneity impacts the success or failure of anti-cancer therapies. Here, we investigated the evolution and mechanistic heterogeneity...
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Effects of exercise, metformin, and combination treatments on type 2 diabetic mellitus-induced muscle atrophy in db/db mice: Crosstalk between autophagy and the proteasome
Both exercise and metformin are common effective clinical treatments of type 2 diabetic mellitus. This study investigated the functional role of...
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MUC20 regulated by extrachromosomal circular DNA attenuates proteasome inhibitor resistance of multiple myeloma by modulating cuproptosis
BackgroundProteasome inhibitors (PIs) are one of the most important classes of drugs for the treatment of multiple myeloma (MM). However, almost all...
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Interactions Between the Ubiquitin–Proteasome System, Nrf2, and the Cannabinoidome as Protective Strategies to Combat Neurodegeneration: Review on Experimental Evidence
Neurodegenerative disorders are chronic brain diseases that affect humans worldwide. Although many different factors are thought to be involved in...
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Rational drug combination design in patient-derived avatars reveals effective inhibition of hepatocellular carcinoma with proteasome and CDK inhibitors
BackgroundHepatocellular carcinoma (HCC) remains difficult to treat due to limited effective treatment options. While the proteasome inhibitor...
