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Autoimmune Lymphoproliferative Syndrome
Autoimmune lymphoproliferative syndrome (ALPS) is an autoimmune disorder characterized by a polyclonal lymphoproliferation that leads to...
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Microorganisms in Pathogenesis and Management of Autoimmune Hepatitis (AIH)
Autoimmune hepatitis (AIH) is the inflammation of the liver that occurs when your body’s immune system turns against liver cells. AIH is more...
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Evolution of Anti-B Cell Therapeutics in Autoimmune Neurological Diseases
B cells have an ever-increasing role in the etiopathology of a number of autoimmune neurological disorders, acting as antigen-presenting cells...
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Disease Progression of WHIM Syndrome in an International Cohort of 66 Pediatric and Adult Patients
Warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome (WS) is a combined immunodeficiency caused by gain-of-function mutations...
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Duvelisib plus romidepsin in relapsed/refractory T cell lymphomas: a phase 1b/2a trial
PI3K-δ inhibitors have shown impressive activity in lymphoid malignancies but have been hampered by autoimmune and infectious toxicities, leading to...
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Tofacitinib for the treatment of severe rare skin diseases: a narrative review
PurposeAutoimmune bullous diseases, connective tissue diseases, and vasculitis represent a group of severe rare skin diseases. While glucocorticoids...
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Antibody-Based Biotherapeutics in Cancer
In this chapter, the different classes and characteristics of mAbs used as cancer therapeutics are described. Safety aspects of selected antibodies...
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Mechanisms of vascular inflammation in deficiency of adenosine deaminase 2 (DADA2)
Deficiency of adenosine deaminase 2 (DADA2) was first described as a monogenic form of systemic vasculitis that closely resembles polyarteritis...
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Immune responses to human fungal pathogens and therapeutic prospects
Pathogenic fungi have emerged as significant causes of infectious morbidity and death in patients with acquired immunodeficiency conditions such as...
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Updates on the mechanisms of toxicities associated with monoclonal antibodies targeting growth factor signaling and immune cells in cancer
Monoclonal antibody (mAb)-based immunotherapy currently is considered to be an optimal therapeutic approach to cancer treatment, either in...
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A randomized phase 2 study of neoadjuvant carboplatin and paclitaxel with or without atezolizumab in triple negative breast cancer (TNBC) - NCI 10013
Atezolizumab with chemotherapy has shown improved progression-free and overall survival in patients with metastatic PD-L1 positive triple negative...
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Hematopoietic Cell Transplantation Cures Adenosine Deaminase 2 Deficiency: Report on 30 Patients
PurposeDeficiency of adenosine deaminase 2 (DADA2) is an inherited inborn error of immunity, characterized by autoinflammation (recurrent fever),...
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Oncolytic T-VEC virotherapy plus neoadjuvant chemotherapy in nonmetastatic triple-negative breast cancer: a phase 2 trial
Talimogene laherparepvec (T-VEC) is an oncolytic virus hypothesized to enhance triple-negative breast cancer (TNBC) responses to neoadjuvant...
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Selective inhibition of peptidyl-arginine deiminase (PAD): can it control multiple inflammatory disorders as a promising therapeutic strategy?
Peptidyl arginine deiminases (PADs) are a family of post-translational modification enzymes that irreversibly citrullinate (deiminate) arginine...
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Selective JAKinibs: Prospects in Inflammatory and Autoimmune Diseases
Cytokines, many of which signal through the JAK–STAT (Janus kinase–Signal Transducers and Activators of Transcription) pathway, play a central role...
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PSCA-CAR T cell therapy in metastatic castration-resistant prostate cancer: a phase 1 trial
Despite recent therapeutic advances, metastatic castration-resistant prostate cancer (mCRPC) remains lethal. Chimeric antigen receptor (CAR) T cell...
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Trastuzumab deruxtecan in HER2-positive breast cancer with brain metastases: a single-arm, phase 2 trial
Trastuzumab deruxtecan is an antibody–drug conjugate with high extracranial activity in human epidermal growth factor receptor 2 (HER2)-positive...
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Therapeutic targeting of the functionally elusive TAM receptor family
The TAM receptor family of TYRO3, AXL and MERTK regulates tissue and immune homeostasis. Aberrant TAM receptor signalling has been linked to a range...
