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Screening for Antibody Deficiencies in Adults by Serum Electrophoresis and Calculated Globin
PurposeThis study aimed to investigate the correlation between calculated globulin (CG, total protein level minus albumin level) and the gamma...
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Primary antibody deficiencies in Turkey: molecular and clinical aspects
Primary antibody deficiencies (PAD) are the most common subtype of primary immunodeficiencies, characterized by increased susceptibility to...
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Identifying Safety Thresholds for Immunosuppressive Drugs: Applying Insights from Primary Antibody Deficiencies to Mitigate Adverse Events in Secondary Antibody Deficiencies Using Mathematical Modeling of Preclinical and Early Clinical Data
Immunosuppressive drugs can alleviate debilitating symptoms of autoimmune diseases, but, by the same token, excessive immune suppression can result...
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Clinical Validation of a Primary Antibody Deficiency Screening Algorithm for Primary Care
PurposeThe diagnostic delay of primary antibody deficiencies (PADs) is associated with increased morbidity, mortality, and healthcare costs....
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A Novel Point-of-Care Rapid Diagnostic Test for Screening Individuals for Antibody Deficiencies
PurposeNo rapid diagnostic test exists to screen individuals for primary antibody deficiencies (PAD) at or near the point of care. In settings at...
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Primary Antibody Deficiencies
Primary antibody deficiencies (PADs) are the most common types of inherited primary immunodeficiency diseases (PIDs) presenting at any age, with a...
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Defining Clinical and Immunological Predictors of Poor Immune Responses to COVID-19 mRNA Vaccines in Patients with Primary Antibody Deficiency
Immune responses to coronavirus disease 2019 (COVID-19) mRNA vaccines in primary antibody deficiencies (PADs) are largely unknown. We investigated...
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Case Series: Convalescent Plasma Therapy for Patients with COVID-19 and Primary Antibody Deficiency
Patients with primary antibody deficiency are at risk for severe and in many cases for prolonged COVID-19. Convalescent plasma treatment of...
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Molecular Dynamics Methods for Antibody Design
Complex and coordinated dynamics are closely connected with protein functions, including the binding of antibodies to antigens. Knowledge of such...
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Predominant Antibody Deficiency and Risk of Microscopic Colitis: a Nationwide Case–Control Study in Sweden
PurposePredominant antibody deficiency (PAD) disorders, including common variable immunodeficiency (CVID), have been linked to increased risk of...
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Current Trends in Validating Antibody Specificities for ELISpot by Western Blotting
The enzyme-linked immunospot (ELISpot) assay is a highly useful and sensitive method to detect total immunoglobulin and antigen-specific...
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Clinical Outcome and Underlying Genetic Cause of Functional Terminal Complement Pathway Deficiencies in a Multicenter UK Cohort
BackgroundTerminal complement pathway deficiencies often present with severe and recurrent infections. There is a lack of good-quality data on these...
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Immunological and Clinical Phenoty** in Primary Antibody Deficiencies: a Growing Disease Spectrum
PurposeAlthough common variable immunodeficiency (CVID) is considered the most prevalent symptomatic primary antibody deficiency (PAD), there is a...
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Single-domain antibody-based protein degrader for synucleinopathies
Synucleinopathies are a group of neurodegenerative diseases characterized by the accumulation of α-synuclein (α-syn) in the brain, leading to motor...
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T cell independent antibody responses with class switch and memory using peptides anchored on liposomes
Vaccines generally require T lymphocytes for B-cell activation and immunoglobulin class switching in response to peptide or protein antigens. In the...
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SARS-CoV-2-Specific and Functional Cytotoxic CD8 Cells in Primary Antibody Deficiency: Natural Infection and Response to Vaccine
PurposeCD8 cytotoxic T cells (CTLs) play a critical role in the clearance of virally infected cells. SARS-CoV-2-specific CD8 T cells and functional...
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Antibody-independent protection against heterologous SARS-CoV-2 challenge conferred by prior infection or vaccination
Vaccines have reduced severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) morbidity and mortality, yet emerging variants challenge their...
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Common Variable Immunodeficiency, Hypogammaglobulinemia, and Specific Antibody Deficiency
Antibody deficiencies are a group of primary immune deficiencies caused by defects in B-cell development, B-cell activation, or antibody synthesis....