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Pharmacological interaction and immune response of purinergic receptors in therapeutic modulation
Nucleosides and purine nucleotides serve as transmitter and modulator agents that extend their functions beyond the cell. In this context, purinergic...
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Altitude Acclimatization Via Pharmacological and Non-pharmacological Interventions
The key element of hypobaric hypoxia is declined barometric pressure and lower partial pressure at high altitudes. Hypobaric hypoxia at high...
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Predictive biomarkers of immunotherapy response with pharmacological applications in solid tumors
Immune-checkpoint inhibitors show promising effects in the treatment of multiple tumor types. Biomarkers are biological indicators used to select...
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Gastrodin: a comprehensive pharmacological review
Tianma is the dried tuber of Gastrodia elata Blume ( G. elata ), which is frequently utilized in clinical practice as a traditional Chinese medicine....
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Enhancing Fear Extinction: Pharmacological Approaches
Extinction is the process by which the memory of a learned conditioned association decreases over time and with introduction of new associations. It...
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Pharmacological Modulation of the Cytosolic Oscillator Affects Glioblastoma Cell Biology
The circadian system is a conserved time-kee** machinery that regulates a wide range of processes such as sleep/wake, feeding/fasting, and...
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Research progress on pharmacological effects and bioavailability of berberine
Berberine (BBR), a benzylisoquinoline alkaloid obtained from natural medicines such as coptidis rhizoma , has a wide range of pharmacological...
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Pharmacological diacylglycerol lipase inhibition impairs contextual fear extinction in mice
Acquisition and extinction of associative fear memories are critical for guiding adaptive behavioral responses to environmental threats, and...
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Pharmacological differences between human and mouse P2X4 receptor explored using old and new tools
There is growing interest in the P2X4 receptor as a therapeutic target for several cardiovascular, inflammatory and neurological conditions. Key to...
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Pharmacological update of mirtazapine: a narrative literature review
Mirtazapine (MTZ) is an antidepressant drug with an exceptional pharmacological profile. It also has an excellent safety and tolerability profile....
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Antitumor pharmacological research in the era of personalized medicine
Anticancer drug discovery has yielded unprecedented progress in recent decades, resulting in the approval of innovative treatment options for...
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A comprehensive review on Schisandrin and its pharmacological features
Schisandrin stands as one of the primary active compounds within the widely used traditional medicinal plant Schisandra chinensis (Turcz.) Baill....
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Pharmacological targeting of coagulation factor XI attenuates experimental autoimmune encephalomyelitis in mice
Multiple sclerosis (MS) is the most common causes of non-traumatic disability in young adults worldwide. MS pathophysiologies include the formation...
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Auditory brainstem responses are resistant to pharmacological modulation in Sprague Dawley wild-type and Neurexin1α knockout rats
Sensory processing in the auditory brainstem can be studied with auditory brainstem responses (ABRs) across species. There is, however, a limited...
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Pharmacological Profile of FDA-Approved Orphan Drugs in the Year 2022
Purpose of ReviewThis manuscript aimed to provide a scientific report of recently FDA-approved orphan drugs for hel** patients, researchers,...
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Pharmacological Inhibition of PTEN Rescues Dopaminergic Neurons by Attenuating Apoptotic and Neuroinflammatory Signaling Events
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the selective degeneration of dopaminergic neurons in the substan...
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Sonchus oleraceus L.: ethnomedical, phytochemical and pharmacological aspects
Sonchus oleraceus L. (Asteraceae) is a cosmopolitan species native to Europe commonly known as lettuce, sowthistle, chicory, or fake dandelion,...
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It Began with the Pharmacological Evaluation of Endocrine Disruptors
In this chapter, we show how we can demonstrate rat hyperactivity by endocrine disruptors with a combination of pharmacological approaches and the...
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Beneficial action of cinnamic acid against ovarian cancer via network pharmacology analysis and the pharmacological activity assessment
Naturally occurring cinnamic acid (CA) shows the beneficial potential in the suppression of ovarian cancer (OC). Currently, the in-depth molecular...
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Review of the potential pharmacological role of erucic acid: a monounsaturated omega-9 fatty acid
This comprehensive review aims to provide an overview of the pharmacological properties of erucic acid (EA) and highlight areas that require further...
