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Clinical Pharmacokinetic Studies
Drug efficacy and response are a function of drug concentration over time. In clinical pharmacokinetic studies, aspects of drug absorption,...
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Multi-compound and drug-combination pharmacokinetic research on Chinese herbal medicines
Traditional medicine has provided a basis for health care and disease treatment to Chinese people for millennia, and herbal medicines are regulated...
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Formulation development and pharmacokinetic evaluation of enteric-coated dexrabeprazole tablets
PurposeThis study investigated the development of an enteric-coated tablet of dexrabeprazole, the R(+)-isomer of rabeprazole, and evaluated the...
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Nanomaterials: Compatibility Towards Biological Interactions
With the expansion of nanotechnology, health care sector has seen a boom in the field of diagnostics and therapeutics. Despite heaps of research,...
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Comparative pharmacokinetic evaluation of nanoparticle-based vs. conventional pharmaceuticals containing statins in attenuating dyslipidaemia
Dyslipidaemia describes the condition of abnormal lipid levels in a person’s bloodstream. Since the 1980s, statin medications have been used to treat...
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Gastroretentive Floating Microsponges of Mitiglinide: Design, Preparation, and Pharmacokinetic Evaluation
PurposeGastroretentive floating microsponges are interesting because they remain buoyant for a long time and release the drug gradually to avoid...
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Quercetin-Loaded Nanostructured Lipid Carrier In Situ Gel for Brain Targeting Through Intranasal Route: Formulation, In Vivo Pharmacokinetic and Pharmacodynamic Studies
Quercetin (QT) shows potential for protecting against neurodegenerative diseases like Alzheimer’s. However, its limited bioavailability and...
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Lipophilic Conjugates of Drugs: A Tool to Improve Drug Pharmacokinetic and Therapeutic Profiles
Lipophilic conjugates (LCs) of small molecule drugs have been used widely in clinical and pre-clinical studies to achieve a number of pharmacokinetic...
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ApoE3 Anchored Liposomal Delivery of Rivastigmine for Brain Delivery: Formulation, Characterization, and In Vivo Pharmacokinetic Evaluation
Rivastigmine hydrogen tartrate (RHT) is an acetylcholinesterase (AChE) inhibitor used in the management of Alzheimer’s disease (AD). RHT is a BCS...
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Raloxifene encapsulated spanlastic nanogel for the prevention of bone fracture risk via transdermal administration: Pharmacokinetic and efficacy study in animal model
This research work is to evaluate spanlastic-loaded raloxifene (RLX) nanogel administration via the transdermal route to avoid its hepatic metabolism...
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Pharmacokinetic Comparison of Nine Bioactive Compounds of Guanxinshutong Capsule in Normal and Acute Myocardial Infarction Rats
Background and ObjectivesGuanxinshutong capsules (GXST) are usually used to treat acute myocardial infarction (AMI), and the clinical effect of GXST...
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Pharmacokinetic modulation of substrate drugs via the inhibition of drug-metabolizing enzymes and transporters using pharmaceutical excipients
BackgroundPharmaceutical excipients are used for formulating drugs to suit their intended use and effect. These excipients influence drug solubility,...
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Formulation, Characterization, Optimization, and Pharmacokinetic Evaluation of Cilnidipine-Loaded Liquisolid Compacts with Improved Dissolution and Bioavailability
PurposeCilnidipine (BCS class II drug) is a calcium channel blocker used in the treatment of hypertension. Poor water solubility, unreliable oral...
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Self-nanoemulsifying drug delivery system (SNEDDS) mediated improved oral bioavailability of thymoquinone: optimization, characterization, pharmacokinetic, and hepatotoxicity studies
Thymoquinone (TQ) is an antioxidant, anti-inflammatory, and hepatoprotective compound obtained from the black seed oil of Nigella sativa . However,...
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Pharmacologically significant constituents collectively responsible for anti-sepsis action of XueBi**g, a Chinese herb-based intravenous formulation
Sepsis, a life-threatening health issue, lacks effective medicine targeting the septic response. In China, treatment combining the intravenous herbal...
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Development and pharmacokinetic evaluation of osmotically controlled drug delivery system of Valganciclovir HCl for potential application in the treatment of CMV retinitis
Valganciclovir HCl (VGH) is the widely used drug for the treatment of cytomegalovirus (CMV) retinitis infection with an induction dose of 900 mg per...
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"Off/On” Fluorescent Probe based on Aggregation-Induced Quenching of ZnO-Quantum dots for Determination of Ara-C: Pharmacokinetic Applications, Adsorption Kinetics & Green Profile Assessment
Herein, a turn “Off/On” fluorescence probe based on ZnO quantum dots (ZnO-QDs) has been proposed and successfully utilized for the determination of...
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Self-nanoemulsifying drug delivery system (SNEDDS) of docetaxel and carvacrol synergizes the anticancer activity and enables safer toxicity profile: optimization, and in-vitro, ex-vivo and in-vivo pharmacokinetic evaluation
Docetaxel (DTX) is a first-line chemotherapeutic molecule with a broad-spectrum anticancer activity. On the other hand, carvacrol (CV) has...
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Enhanced Dermal Delivery of Flurbiprofen Nanosuspension Based Gel: Development and Ex Vivo Permeation, Pharmacokinetic Evaluations
PurposeThe objective of this study was to optimize the Flurbiprofen (FB) nanosuspension (NS) based gel and to investigate the in vitro release, ex...
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Design of experiment (DoE)-based formulation design of bepotastine sustained-release tablet and in vitro-in vivo pharmacokinetic correlation
PurposeBepotastine besilate, a second-generation antihistamine commonly prescribed to treat allergic rhinitis and urticarial/pruritus, has a short...
