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Pharmacokinetics and Pharmacodynamics of Therapeutic Proteins and Nucleic Acids
The rational use of drugs and the design of effective dosage regimens are facilitated by the appreciation of the central paradigm of clinical...
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Optimizing Antibiotic Therapy for Intravenous Drug Users: A Narrative Review Unraveling Pharmacokinetics/Pharmacodynamics Challenges
Intravenous drug users (IVDUs) face heightened susceptibility to life-threatening gram-positive bacterial infections, particularly...
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Pharmacokinetics and Pharmacodynamics: Fundamentals and Role(s) in Drug Discovery and Development
The process of finding new drugs begins with the identification of a target and its validation, then hits are found, leads are generated, and they...
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Challenges of pediatric pharmacotherapy: A narrative review of pharmacokinetics, pharmacodynamics, and pharmacogenetics
PurposePersonalized pharmacotherapy, including for the pediatric population, provides optimal treatment and has emerged as a major trend owing to...
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Pharmacokinetics and pharmacodynamics of perfluoropropane after intra-venous bolus injection of perflutren lipid microsphere injection (DEFINITY®) in healthy Chinese volunteers
Background and objectiveDefinity is an ultrasound contrast agent consisting of phospholipids-encapsulated perfluoropropane (PFP), also known as...
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Preparation of semaglutide long-acting injectable microcapsules with physicochemical properties, long-term stability, and pharmacokinetics and pharmacodynamics
PurposeTo develop once-a-month long acting semaglutide injectable, its manufacturing process was optimized. The final product to be selected based on...
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Targeted next-generation sequencing of genes involved in Warfarin Pharmacodynamics and pharmacokinetics pathways using the Saudi Warfarin Pharmacogenetic study (SWAP)
BackgroundWarfarin is an oral anticoagulant commonly used for treatment and prophylaxis against thromboembolic events. Warfarins’s narrow therapeutic...
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Assembly of In-Situ Gel Containing Nano-Spanlastics of an Angiotensin II Inhibitor as a Novel Epitome for Hypertension Management: Factorial Design Optimization, In-vitro Gauging, Pharmacokinetics, and Pharmacodynamics Appraisal
More than 1 billion people worldwide suffer from hypertension; therefore, hypertension management has been categorized as a global health priority....
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Clinical pharmacokinetics and pharmacodynamics of ivosidenib in Chinese patients with relapsed or refractory IDH1-mutated acute myeloid leukemia
PurposeThis study aimed to assess the pharmacokinetics (PK) and pharmacodynamics (PD) of ivosidenib in Chinese patients with relapsed or refractory...
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Population pharmacokinetics and pharmacodynamics of efmarodocokin alfa (IL-22Fc)
Efmarodocokin alfa (IL-22Fc) is a fusion protein of human IL-22 linked to the crystallizable fragment (Fc) of human IgG4. It has been tested in...
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Influence of Gegenqinlian Decoction on Pharmacokinetics and Pharmacodynamics of Atorvastatin Calcium in Hyperlipidemic Rats
Background and ObjectivesGegenqinlian decoction (GQD), a classic traditional Chinese medicine (TCM), was described in Shanghan Lun. GQD is often...
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Murine pharmacokinetics and antimalarial pharmacodynamics of dihydroartemisinin trimer self-assembled nanoparticles
Currently, conjugation of artemisinin-derived dimers, trimers, and tetramers is a viable strategy for develo** new effective antimalarial...
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Safety, tolerability, pharmacokinetics, and pharmacodynamics of a novel kappa opioid receptor agonist ZYKR1: a randomized double-blind placebo-control phase 1 study in healthy adult human participants
To perform first-in-human single-dose escalation trial of ZYKR1, which is a potent, selective, and peripherally-restricted kappa opioid receptor...
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First-in-Human Study of the Safety, Pharmacokinetics, and Pharmacodynamics of MHV370, a Dual Inhibitor of Toll-Like Receptors 7 and 8, in Healthy Adults
Background and ObjectiveMHV370, a dual antagonist of human Toll-like receptors (TLR) 7 and 8, suppresses cytokines and interferon-stimulated genes in...
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Safety, tolerability, pharmacokinetics, and pharmacodynamics of BI 685509, a soluble guanylyl cyclase activator, in healthy volunteers: Results from two randomized controlled trials
This study evaluated the safety, tolerability, pharmacokinetics, and pharmacodynamics of BI 685509 after oral single rising doses (SRDs) or multiple...
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Clinical Pharmacokinetics and Pharmacodynamics of Esaxerenone, a Novel Mineralocorticoid Receptor Antagonist: A Review
Esaxerenone is a selective, nonsteroidal, high-affinity mineralocorticoid receptor antagonist recently approved in Japan for the treatment of...
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Scipion PKPD: an Open-Source Platform for Biopharmaceutics, Pharmacokinetics and Pharmacodynamics Data Analysis
PurposeBiopharmaceutics examines the interrelationship of the drug’s physical/chemical properties, the dosage form (drug product) in which the drug...
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Pharmacokinetics and Pharmacodynamics of Neonatal Fc Receptor (FcRn)-Targeting Therapeutic Proteins: a Systemic Review
Purpose of ReviewVarious therapeutic strategies have been utilized to optimize the function of neonatal Fc receptor (FcRn), facilitating the binding...