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HIV transmitting mononuclear phagocytes; integrating the old and new
In tissue, mononuclear phagocytes (MNP) are comprised of Langerhans cells, dendritic cells, macrophages and monocyte-derived cells. They are the...
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Harnessing retinal phagocytes to combat pathological neovascularization in ischemic retinopathies?
Ischemic retinopathies (IR) are vision-threatening diseases that affect a substantial amount of people across all age groups worldwide. The current...
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HIF activation enhances FcγRIIb expression on mononuclear phagocytes impeding tumor targeting antibody immunotherapy
BackgroundHypoxia is a hallmark of the tumor microenvironment (TME) and in addition to altering metabolism in cancer cells, it transforms...
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The Role of Intracellular Signaling Molecules in the Production of Granulocytic CSF Mononuclear Phagocytes in Stress and Cytostatic Influence
Under conditions of steady-state hemopoiesis, nuclear factor NF-κB, in contrast to MAP kinase p38, plays an important role in the maintenance of the...
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Nanocages displaying SIRP gamma clusters combined with prophagocytic stimulus of phagocytes potentiate anti-tumor immunity
Antigen-presenting cells (APCs), including macrophages and dendritic cells (DCs), play a crucial role in bridging innate and adaptive immunity;...
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A Novel Assay in Whole Blood Demonstrates Restoration of Mitochondrial Activity in Phagocytes After Successful HSCT in Hyperinflamed X-Linked Chronic Granulomatous Disease
X-linked chronic granulomatous disease is a rare disease caused by mutations in the CYBB gene. While more extensive knowledge is available on...
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IRF5 Signaling in Phagocytes Is Detrimental to Neonatal Hypoxic Ischemic Encephalopathy
Immune responses to neonatal hypoxic ischemic encephalopathy (HIE) exacerbate brain injury. Phagocytes, including microglia, play a central role in...
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Deletion of CD47 from Schwann cells and macrophages hastens myelin disruption/dismantling and scavenging in Schwann cells and augments myelin debris phagocytosis in macrophages
BackgroundMyelin that surrounds axons breaks in trauma and disease; e.g., peripheral nerve and spinal cord injuries (PNI and SCI) and multiple...
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Subsets of mononuclear phagocytes are enriched in the inflamed colons of patients with IBD
BackgroundMyeloid cells, especially mononuclear phagocytes, which include monocytes, macrophages and dendritic cells (DC), play vital roles in innate...
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After cell death: the molecular machinery of efferocytosis
Cells constituting a multicellular organism die in a variety of ways throughout life, and most of them die via apoptosis under normal conditions. The...
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Salmonella spvC gene suppresses macrophage/neutrophil antibacterial defense mediated by gasdermin D
ObjectiveSalmonella enterica serovar Typhimurium ( S . Typhimurium) is a representative model organism for investigating host–pathogen interactions....
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Measurement of Respiratory Burst Products, Released or Retained, During Activation of Professional Phagocytes
Activation of professional phagocytes, potent microbial killers of our innate immune system, is associated with an increased cellular consumption of...
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Apoptosis and Phagocytosis as Antiviral Mechanisms
Viruses are infectious entities that make use of the replication machinery of their hosts to produce more progenies, causing disease and sometimes...
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Molecular analysis of Annexin expression in cancer
BackgroundUptake of apoptotic cells induces a tolerogenic phenotype in phagocytes and promotes peripheral tolerance. The highly conserved Annexin...
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Human serous cavity macrophages and dendritic cells possess counterparts in the mouse with a distinct distribution between species
In mouse peritoneal and other serous cavities, the transcription factor GATA6 drives the identity of the major cavity resident population of...
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Drugging the efferocytosis process: concepts and opportunities
The daily removal of billions of apoptotic cells in the human body via the process of efferocytosis is essential for homeostasis. To allow for this...
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Intercalated cell function, kidney innate immunity, and urinary tract infections
Intercalated cells (ICs) in the kidney collecting duct have a versatile role in acid–base and electrolyte regulation along with the host immune...
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Antifungal Susceptibility Testing and Drug Discovery in the Dimorphic Fungus Histoplasma Capsulatum
The thermal dimorphism of the fungal pathogen Histoplasma is linked to its virulence in mammalian hosts. Mammalian body temperature triggers...
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Dexmedetomidine attenuates hippocampal neuroinflammation in postoperative neurocognitive disorders by inhibiting microRNA-329-3p and activating the CREB1/IL1RA axis
RationaleDue to its anti-inflammatory effect, dexmedetomidine (DEX) can confer neuroprotection in postoperative neurocognitive disorders (NCD). Here,...
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Understanding the Phagocytosis of Particles: the Key for Rational Design of Vaccines and Therapeutics
A robust comprehension of phagocytosis is crucial for understanding its importance in innate immunity. A detailed description of the molecular...
