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Neuroendocrinology of Perinatal Mental Illness
Mental illness during pregnancy and the postpartum period is a growing health crisis. We know that at least 1 in 7 women during the perinatal...
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Astaxanthin and DHA Supplementation Modulates the Maternal Undernutrition-induced Impairment of Cognitive Behavior and Synaptic Plasticity in Adult Life of Offspring’s -Exploring the Molecular Mechanism
Maternal nutrition was recognized as a significant part of brain growth and maturation in most mammalian species. Timely intervention with suitable...
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Metabolic Plasticity in Develo** and Aging Brain
Abstract —Brain plasticity is a fundamental phenomenon based on various types of intercellular interactions (synaptic activity, neuritogenesis,...
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Executive functioning, ADHD symptoms and resting state functional connectivity in children with perinatal stroke
Perinatal stroke describes a group of focal, vascular brain injuries that occur early in development, often resulting in lifelong disability. Two...
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Metabolic Perturbations Associated with both PFAS Exposure and Perinatal/Antenatal Depression in Pregnant Individuals: A Meet-in-the-Middle Sco** Review
Purpose of ReviewDepression during the perinatal or antenatal period affects at least 1 in 10 women worldwide, with long term health implications for...
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Potential Key Proteins, Molecular Networks, and Pathways in Perinatal Hypoxia
Perinatal hypoxia is a common risk factor for CNS development. Using bioinformatics databases, a list of 129 genes involved in perinatal hypoxia was...
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Salifen Prevents Perinatal Hypoxia-Induced Cognitive Impairments and Changes in the Expression of GABAB Receptors in the Rat Neocortex
We report here a study examining the effects of acute normobaric hypoxia in the early postnatal period of development (postnatal day 2) on learning...
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Perinatal Stressors as a Factor in Impairments to Nervous System Development and Functions: Review of In Vivo Models
The human body is faced with stress throughout ontogeny. At the stage of intrauterine development, the mother’s body serves as a source of resources...
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Neurobehavioral Characterization of Perinatal Oxycodone-Exposed Offspring in Early Adolescence
The opioid epidemic has received considerable attention, but the impact on perinatal opioid-exposed (POE) offspring remains underexplored. This study...
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Aluminum-Induced Electrophysiological Variation, Synaptic Plasticity Impairment, and Related Mechanism
Aluminum, an environmentally abundant non-redox trivalent cation, has long been reported to alter blood-brain barrier and gets deposited in different...
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Vagus Nerve Manipulation and Microglial Plasticity in the Prenatal Brain
The efferent and afferent effects of the vagus nerve on the develo** brain have remained enigmatic. Here we review the evidence of such effects on...
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Effect of Early Inhibition of Toll-Like Receptor 4 on Hippocampal Plasticity in a Neonatal Rat Model of Hypoxic-Ischemic Brain Damage
Hippocampal plasticity is closely related to physiological brain functions such as learning and memory. However, the effect of toll-like receptor 4...
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Improving behavioral deficits induced by perinatal ethanol and stress exposure in adolescent male rat progeny via maternal melatonin treatment
Background and aimEarly-life stressful situations and binge drinking have been thus far acknowledged as two burdensome conditions that potentially...
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Neonatal inflammation increases hippocampal KCC2 expression through methylation-mediated TGF-β1 downregulation leading to impaired hippocampal cognitive function and synaptic plasticity in adult mice
The mechanisms by which neonatal inflammation leads to cognitive deficits in adulthood remain poorly understood. Inhibitory GABAergic synaptic...
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MDGA2 Constrains Glutamatergic Inputs Selectively onto CA1 Pyramidal Neurons to Optimize Neural Circuits for Plasticity, Memory, and Social Behavior
Synapse organizers are essential for the development, transmission, and plasticity of synapses. Acting as rare synapse suppressors, the MAM domain...
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Molecular, Cellular, and Behavioural Effects Produced by Perinatal Asphyxia: Protection by Poly (ADP-Ribose) Polymerase 1 (PARP-1) Inhibition
Perinatal asphyxia implies oxygen interruption at birth, leading to death whenever reoxygenation is not promptly reestablished. Reoxygenation...
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Brain Recovery in Childhood: The Interaction Between Developmental Plasticity and Regenerative Mechanisms
Stroke is one of the ten leading causes of death in children and adolescents ages 1–18. Pediatric stroke has some specific characteristics that make...
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Recent Investigations on Neurotransmitters’ Role in Acute White Matter Injury of Perinatal Glia and Pharmacotherapies—Glia Dynamics in Stem Cell Therapy
Periventricular leukomalacia (PVL) and cerebral palsy are two neurological disease conditions developed from the premyelinated white matter ischemic...
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Involvement of Cdk5 activating subunit p35 in synaptic plasticity in excitatory and inhibitory neurons
Cyclin-dependent kinase 5 (Cdk5) /p35 is involved in many developmental processes of the central nervous system. Cdk5/p35 is also implicated in...
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The Combined Effects of Perinatal Ethanol and Early-Life Stress on Cognition and Risk-Taking Behavior through Oxidative Stress in Rats
Both prenatal ethanol and early-life stress have been shown to induce reduced risk-taking and explorative behavior as well as cognitive dysfunction...
