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The Influence of the Synthetic Organoselenium Preparation 974zh on the Immunogenic Activity of Yersinia pestis EV Vaccine Strain NIIEG
In the present study, a stimulating effect of a new synthetic organoselenium compound 2,6-dipyridinium-9-selenabicyclo[3.3.1]nonandibromide (974zh)...
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Evaluation of novel multifunctional organoselenium compounds as potential cholinesterase inhibitors against Alzheimer’s disease
Acetylcholinesterase (AChE) inhibitors are of widespread interest to the pharmaceutical communities. Herein, 34 organoselenium compounds were...
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Effect of a Synthetic Organoselenium Compound on Post-Vaccination Immunopoiesis in the Red Bone Marrow and Cell Composition of Peripheral Blood of White Mice Vaccinated with Yersinia pestis EV
We studied the effect of an experimental synthetic organoselenium compound 2,6-dipyridinium- 9-selenabicyclo[3.3.1]nonane dibromide (974zh) on the...
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Toxicology and pharmacology of synthetic organoselenium compounds: an update
Here, we addressed the pharmacology and toxicology of synthetic organoselenium compounds and some naturally occurring organoselenium amino acids. The...
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Organosulfur and Organoselenium Functionalized Benzimidazo[1,2-a]quinolines: From Experimental and Theoretical Photophysics to All-Solution-Processed OLEDs
In this study, we present the synthesis of benzimidazo[1,2- a ] quinoline-based heterocycles bearing organosulfur and organoselenium moieties through...
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A Purine Derivative Containing an Organoselenium Group Protects Against Memory Impairment, Sensitivity to Nociception, Oxidative Damage, and Neuroinflammation in a Mouse Model of Alzheimer’s Disease
In the present study, the effect of 6-((4-fluorophenyl) selanyl)-9 H -purine (FSP) was tested against memory impairment and sensitivity to nociception...
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Dynamics of Changes in the cAMP/cGMP Concentration Ratio in the Thymus and Spleen of Laboratory Mice during Vaccination against Plague and Tularemia against the Background of Immunomodulation
Vaccine strains Yersinia pestis EV NIIEG at a dose of 10 3 CFU and Francisella tularensis 15 NIIEG at a dose of 10 2 CFU induced changes in the...
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The Thiol-Modifier Effects of Organoselenium Compounds and Their Cytoprotective Actions in Neuronal Cells
Most pharmacological studies concerning the beneficial effects of organoselenium compounds have focused on their ability to mimic glutathione...
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Effect of Synthetic Organoselenium Drug on the Degree of Pathological Changes in the Organs of White Mice Immunized with Tularemia and Brucellosis Vaccines
We studied the effect of the organoselenium compound 2,6-dipyridinium-9-selenium-bicyclo[ 3,3,1]nonan dibromide (974zh) on the severity of...
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Diphenyl Diselenide Through Reduction of Inflammation, Oxidative Injury and Caspase-3 Activation Abates Doxorubicin-Induced Neurotoxicity in Rats
Neurotoxicity associated with chemotherapy is a debilitating side effect of cancer management in humans which reportedly involves inflammatory and...
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N-(3-((3-(trifluoromethyl)phenyl)selanyl)prop-2-yn-1-yl) benzamide induces antidepressant-like effect in mice: involvement of the serotonergic system
RationaleMajor Depressive Disorder (MDD) significantly impairs the quality of life for those affected. While the exact causes of MDD are not fully...
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Effect of m-Trifluoromethyl-diphenyl diselenide on the Pain–Depression Dyad Induced by Reserpine: Insights on Oxidative Stress, Apoptotic, and Glucocorticoid Receptor Modulation
Chronic pain and depression often coexist sharing common pathological mechanisms, and available analgesics and antidepressants have demonstrated...
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Oxidative Stress in Cancer
The disease cancer involves multiple cellular and molecular changes, which converts a normal cell into a malignant one. Reactive oxygen species acts...
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Immunotropic Properties of an Experimental Synthetic Selenium-Organic Compound
We studied immunotropic properties of synthetic selenium-organic preparation 2,6-dipyridinium-9-selenabicyclo[3.3.1]nonyl dibromide (974zh). The...
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Antidepressant-like effect of a selenopropargylic benzamide in mice: involvement of the serotonergic system
RationaleMajor depressive disorder is a psychiatric disorder that requires considerable attention, since it dramatically impairs the quality of life...
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Synthesis and Photophysical Study of Tetraphenyl Substituted BODIPY Based Phenyl-Monoselenide Probe for Selective Detection of Superoxide
Selenium containing tetraphenyl substituted BODIPY probe was successfully synthesized from respective selenium aldehyde and tetraphenyl pyrrole using...
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Diphenyl Diselenide Attenuates Mitochondrial Damage During Initial Hypoxia and Enhances Resistance to Recurrent Hypoxia
Hypoxia plays a significant role in the development of various cerebral diseases, many of which are associated with the potential risk of recurrence...
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Selenium Neuroprotection in Neurodegenerative Disorders
Selenium (Se) is an essential element, and severe deficiency of Se is incompatible with human life. Se is part of a restricted group of 25 proteins,...
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Oxidative Stress in Cancer
The disease cancer involves multiple cellular and molecular changes, which converts a normal cell into a malignant one. Reactive oxygen species acts...
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Involvement of the serotonergic system in the antidepressant-like effect of 1-(phenylselanyl)-2-(p-tolyl)indolizine in mice
RationaleDepression is a mental disorder that affects approximately 280 million people worldwide. In the search for new treatments for mood...
