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Noninvasive assessment of organ-specific and shared pathways in multi-organ fibrosis using T1 map**
Fibrotic diseases affect multiple organs and are associated with morbidity and mortality. To examine organ-specific and shared biologic mechanisms...
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Organ and Non-organ-Directed Nanotoxicity
Humans are exposed to various nanoscale materials since childhood, and as such have become a threat to human life. Because of their small size,...
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Organ Chips in Safety Pharmacology
Assessing a drug’s potentially toxic and therapeutic effects on human health is one of the critical stages of drug discovery. Traditionally utilized...
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Immunotherapy in the Solid Organ Transplant Recipient
Checkpoint inhibitor immunotherapy has limited data in the immunosuppressed solid organ transplant recipient population as early use in this...
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Machine Learning for Predicting Organ Toxicity
Organ toxicity is a leading concern in safety assessment for regulatory agencies and pharmaceutical companies. Due to the huge amount of compounds...
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Monoclonal Antibodies in Solid Organ Transplantation
In an attempt to target solid organ transplant immunosuppression, monoclonal antibodies directed against key steps in specific immunologic pathways...
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Multi-organ landscape of therapy-resistant melanoma
Metastasis and failure of present-day therapies represent the most common causes of mortality in patients with cutaneous melanoma. To identify the...
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Organ Toxicity by Immunosuppressive Drugs in Solid Organ Transplantation
Solid organ transplantation is the preferred therapeutic option that confers significant survival advantage on patients suffering from end-organ...
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DAMP sensing and sterile inflammation: intracellular, intercellular and inter-organ pathways
Damage-associated molecular patterns (DAMPs) are endogenous molecules that are released from host cells as a result of cell death or damage. The...
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Inter-organ communication involved in metabolic regulation at the whole-body level
Metabolism in each organ of multi-organ organisms, including humans, is regulated in a coordinated manner to dynamically maintain whole-body...
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Decoding the hallmarks of allograft dysfunction with a comprehensive pan-organ transcriptomic atlas
The pathogenesis of allograft (dys)function has been increasingly studied using ‘omics’-based technologies, but the focus on individual organs has...
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Accuracy of patient-specific CT organ doses from Monte Carlo simulations: influence of CT-based voxel models
Monte Carlo simulations using patient CT images as input are the gold standard to perform patient-specific dosimetry. However, in standard clinical...
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Heterogeneous aging across multiple organ systems and prediction of chronic disease and mortality
Biological aging of human organ systems reflects the interplay of age, chronic disease, lifestyle and genetic risk. Using longitudinal brain imaging...
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Dual encoder network with transformer-CNN for multi-organ segmentation
Medical image segmentation is a critical step in many imaging applications. Automatic segmentation has gained extensive concern using a convolutional...
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Unlocking the secrets: the power of methylation-based cfDNA detection of tissue damage in organ systems
BackgroundDetecting organ and tissue damage is essential for early diagnosis, treatment decisions, and monitoring disease progression....
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Organ, Histotypic and Organotypic Culture, and Tissue Engineering
Organ, histotypic, and organotypic culture using mammalian three-dimensional (3D) cell culture technologies are the primary focus of this chapter....
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Early growth response 2, a novel target of pelvic organ prolapse, is highly expressed in anterior vaginal wall tissues with pelvic organ prolapse
Pelvic organ prolapse (POP) is a common disorder among women that negatively affects women’s quality of life. Early growth response 2 (EGR2) is a...
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Advances and challenges in organ-on-chip technology: toward mimicking human physiology and disease in vitro
Organs-on-chips have been tissues or three-dimensional (3D) mini-organs that comprise numerous cell types and have been produced on microfluidic...
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Circular RNAs in organ injury: recent development
Circular ribonucleic acids (circRNAs) are a class of long non-coding RNA that were once regarded as non-functional transcription byproducts. However,...
