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Activation of Cardiac δ2-Opioid Receptors Increases Heart Tolerance to Reperfusion
Coronary occlusion (45 min) and reperfusion (120 min) in male Wistar rats in vivo , as well as total ischemia (45 min) of an isolated rat heart...
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Opioid Peptides and Their Receptors
Since the discovery of opioid receptors and their endogenous ligands named opioid peptides, it has been established that opiates exert their effects...
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Opioid Peptides and Their Receptors
Since the discovery of opioid receptors and their endogenous ligands named opioid peptides, it has been established that opiates exert their effects...
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The Role of δ2-Opioid Receptors in the Regulation of Tolerance of Isolated Cardiomyocytes to Hypoxia and Reoxygenation
Hypoxia (20 min) and reoxygenation (30 min) were simulated on isolated rat cardiomyocytes to evaluate the cytoprotective effect of selective δ 2 -opioid...
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Neuromodulation in Parkinson’s disease targeting opioid and cannabinoid receptors, understanding the role of NLRP3 pathway: a novel therapeutic approach
Parkinson's disease (PD) is a prevalent neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia...
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Targeting Peripheral μ-opioid Receptors or μ-opioid Receptor-Expressing Neurons Does not Prevent Morphine-induced Mechanical Allodynia and Anti-allodynic Tolerance
The chronic use of morphine and other opioids is associated with opioid-induced hypersensitivity (OIH) and analgesic tolerance. Among the different...
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A Fentanyl Analogue That Activates u-Opioid Receptors in Acidified Tissues Inhibits Colitis Pain without Opioid Side Effects
Opioid agonists are effective analgesics for treating visceral pain but their use is limited by their on-target side effects, such as constipation,...
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Opioid Receptors and Neuronal Signal Transduction
This chapter provides information on the classification, structure, and properties of the main opioidOpioids receptor subtypes, their canonical and...
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Mediation of the behavioral effects of ketamine and (2R,6R)-hydroxynorketamine in mice by kappa opioid receptors
Emerging evidence has implicated the endogenous opioid system in mediating ketamine’s antidepressant activity in subjects with major depressive...
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Delta opioid receptors on nociceptive sensory neurons mediate peripheral endogenous analgesia in colitis
BackgroundInflammatory visceral pain is endogenously controlled by enkephalins locally released by mucosal CD4 + T lymphocytes in mice. The present...
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Effect of Stress on the Production of Antibodies and IL-2, IL-4, and IFNγ Depending on the Time of Antigen Administration and Evaluation of the Role of Opioid Receptors
The time of stress exposure relative to the moment of immunization affects the direction of the immunoregulatory effect of stress. In case of stress...
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NLRs and inflammasome signaling in opioid-induced hyperalgesia and tolerance
We investigated the role that innate immunological signaling pathways, principally nod-like receptors (NLRs) and inflammasomes, in the manifestation...
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Physical Exercise as an Intervention for Depression: Evidence for Efficacy and Mu-Opioid Receptors as a Mechanism of Action
Physical exercise is often cited as an important part of an intervention for depression, and there is empirical evidence to support this. However,...
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The Foundational Science of Endogenous Opioids and Their Receptors
The function of endogenous opioids spans from initiating behaviors that are critical for survival, to responding to rapidly changing environmental...
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Possible mechanism for improving the endogenous immune system through the blockade of peripheral μ-opioid receptors by treatment with naldemedine
BackgroundIt has been considered that activation of peripheral μ-opioid receptors (MORs) induces side effects of opioids. In this study, we...
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Relationship between opioid cross-tolerance during buprenorphine stabilization and return to opioid use during buprenorphine dose tapering
RationaleOpioid injection drug use (IDU) has been linked to a more severe pattern of use (e.g. tolerance, overdose risk) and shorter retention in...
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Neonatal opioid toxicity: opioid withdrawal (abstinence) syndrome with emphasis on pharmacogenomics and respiratory depression
The increasing use of opioids in pregnant women has led to an alarming rise in the number of cases of neonates with drug-induced withdrawal symptoms...
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Regulation of Opioid Receptors by Their Endogenous Opioid Peptides
Activation of μ, δ, and κ opioid receptors by endogenous opioid peptides leads to the regulation of many emotional and physiological responses. The...
