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The neuropharmacological profile of interval responding during operant tasks
Responses occurring during intervals of operant tasks have been subdivided as interim, facultative, and terminal, depending on the time between...
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A head-to-head comparison of two DREADD agonists for suppressing operant behavior in rats via VTA dopamine neuron inhibition
RationaleDesigner receptors exclusively activated by designer drugs (DREADDs) are a tool for “remote control” of defined neuronal populations during...
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Impaired extinction of operant cocaine in a genetic mouse model of schizophrenia risk
BackgroundIndividuals with schizophrenia have high rates of comorbid substance use problems. One potential explanation for this comorbidity is...
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Operant social seeking to a novel peer after social isolation is associated with activation of nucleus accumbens shell in rats
Rationale and ObjectiveDeprivation of social interaction promotes social reward seeking in rodents, assessed primarily by the conditioned place...
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Chronic Social Isolation Stress and Crowding in Rats Have Different Effects on Learning an Operant Behavior and the State of the Hypothalamo-Hypophyseal-Adrenocortical System
Social stress is a widely experienced problem in the contemporary world; it is diverse and is determined by specific living conditions in both humans...
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Acute pain-related depression of operant responding maintained by social interaction or food in male and female rats
RationaleClinically relevant pain is often associated with functional impairment and behavioral depression, including depression of social behavior....
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The GABAB receptor positive allosteric modulator ASP8062 reduces operant alcohol self-administration in male and female Sprague Dawley rats
RationalePre-clinical evidence implicates the GABAergic system in mediating the reinforcing effects of alcohol and offers a therapeutic target for...
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Duration- and sex-dependent neural circuit control of voluntary physical activity
RationaleExercise participation remains low despite clear benefits. Rats engage in voluntary wheel running (VWR) that follows distinct phases of...
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MK-801 Impairs Reconsolidation of a “New” Memory and Affects the “Old” Memory in Operant Feeding-Related Behavior in an Eight-Arm Radial Maze in Rats
Spatial memory deteriorated significantly in feeding-related operant behavior in an eight-arm radial maze in rats as a result of reactivation using a...
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The cerebellum directly modulates the substantia nigra dopaminergic activity
Evidence of direct reciprocal connections between the cerebellum and basal ganglia has challenged the long-held notion that these structures function...
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Leaky Integrate and Fire Neurons
In Chap. 1, Eberhard Fetz describes his joint work with his thesis advisor, George Gerstein, introducing the leaky-integrate-and-fire (LIF) neuron...
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Bayesian prediction of psychophysical detection responses from spike activity in the rat sensorimotor cortex
Decoding of sensorimotor information is essential for brain-computer interfaces (BCIs) as well as in normal functioning organisms. In this study,...
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Imaging Neuronal Activity in Cerebellar Cortex of Behaving Mice
In vivo imaging allows recording of population activity from many cerebellar circuit elements at once. In particular, Purkinje cells, molecular layer...
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Prelimbic and infralimbic medial prefrontal cortex neuron activity signals cocaine seeking variables across multiple timescales
Rationale and ObjectivesThe prefrontal cortex is critical for execution and inhibition of reward seeking. Neural manipulation of rodent medial...
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Psychophysical detection and learning in freely behaving rats: a probabilistic dynamical model for operant conditioning
We present a stochastic learning model that combines the essential elements of Hebbian and Rescorla-Wagner theories for operant conditioning. The...
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Sex and age differences in mice models of effort-based decision-making and anergia in depression: the role of dopamine, and cerebral-dopamine-neurotrophic-factor
Mesolimbic dopamine (DA) regulates vigor in motivated behavior. While previous results have mainly been performed in male rodents, the present...
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Clozapine N-oxide, compound 21, and JHU37160 do not influence effortful reward-seeking behavior in mice
RationaleClozapine N-oxide (CNO) has been developed as a ligand to selectively activate designer receptors exclusively activated by designer drugs...
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Propagation of activity through the cortical hierarchy and perception are determined by neural variability
Brains are composed of anatomically and functionally distinct regions performing specialized tasks, but regions do not operate in isolation....
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Open-Source JL Olfactometer for Awake Behaving Recording of Brain Activity for Mice Engaged in Olfactory Tasks
Automated olfactometers are used to study brain function in rodents engaged in olfactory behavioral tasks. In this chapter, we describe the JL...
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Formation of Different Strategies of Competitive Foraging Behavior in Rats
We studied competitive interactions of rats during instrumental foraging behavior. Two groups of animals were revealed: rats with predominance of...