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Vaccines and Oncolytic Virus for the Treatment of Lung Cancer
Lung cancer is the most prevalent cause of cancer deaths in men and women, with a 5-year survival rate of fewer than 15% due to late-stage diagnosis...
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Integrating system biology and intratumor gene therapy by trans-complementing the appropriate co-stimulatory molecule as payload in oncolytic herpes virus
Systems biology has been applied at the multi-scale level within the cancer field, improving cancer prevention, diagnosis and enabling precision...
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The potential of swine pseudorabies virus attenuated vaccine for oncolytic therapy against malignant tumors
BackgroundOncolytic viruses are now well recognized as potential immunotherapeutic agents against cancer. However, the first FDA-approved oncolytic...
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Fast Track Adaptation of Oncolytic Coxsackie B3 Virus to Resistant Colorectal Cancer Cells - a Method to Personalize Virotherapy
BackgroundThe efficacy of oncolytic viruses (OV) in cancer treatment depends on their ability to successfully infect and destroy tumor cells....
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A viral attack on brain tumors: the potential of oncolytic virus therapy
Managing malignant brain tumors remains a significant therapeutic hurdle that necessitates further research to comprehend their treatment potential...
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The antitumor effect of oncolytic respiratory syncytial virus via the tumor necrosis factor-alpha induction and ROS-bax-mediated mechanisms
BackgroundCervical cancer represents one of the most prevalent cancers among women worldwide, particularly in low- and middle-income nations....
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Repurposing of Zika virus live-attenuated vaccine (ZIKV-LAV) strains as oncolytic viruses targeting human glioblastoma multiforme cells
Glioblastoma multiforme (GBM) is the most common malignant primary brain cancer affecting the adult population. Median overall survival for GBM...
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The role of oncolytic virotherapy and viral oncogenes in the cancer stem cells: a review of virus in cancer stem cells
Cancer Stem Cells (CSCs) are the main “seeds” for the initiation, growth, metastasis, and recurrence of tumors. According to many studies, several...
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Attenuated Dengue virus PV001-DV induces oncolytic tumor cell death and potent immune responses
BackgroundViral therapies developed for cancer treatment have classically prioritized direct oncolytic effects over their immune activating...
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Novel Cancer Treatment Using Oncolytic Virus Therapy
Oncolytic viruses are a unique group of viruses that – either naturally or through genetic modification – induce the destruction of cancer cells....
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Application of Oncolytic Poxviruses: An Emerging Paradigm in Cancer Therapy
Despite the significant advancement of new tools and technology in the field of medical biology and molecular biology, the challenges in the...
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Intratumoral oncolytic herpes virus G47∆ for residual or recurrent glioblastoma: a phase 2 trial
This investigator-initiated, phase 2, single-arm trial primarily assessed the efficacy of G47∆, a triple-mutated, third-generation oncolytic herpes...
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The V protein in oncolytic Newcastle disease virus promotes HepG2 hepatoma cell proliferation at the single-cell level
BackgroundNewcastle disease virus (NDV) is an oncolytic virus that can inhibit cancer cell proliferation and kill cancer cells. The NDV nonstructural...
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Intravesical Infusion of Oncolytic Virus CG0070 in the Treatment of Bladder Cancer
CG0070 is a conditionally replicating oncolytic adenovirus that preferentially replicates within and kills Rb-defective cancer cells. It has been...
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Potent antitumor efficacy of human dental pulp stem cells armed with YSCH-01 oncolytic adenovirus
BackgroundSystemic administration of oncolytic adenovirus for cancer therapy is still a challenge. Mesenchymal stem cells as cell carriers have...
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Oncolytic intralesional therapy for metastatic melanoma
In-transit metastasis (ITM) develop in approximately 1 in 10 patients with melanoma and the disease course can vary widely. Surgical resection is the...
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PD-1 inhibitor plus oncolytic vaccinia virus is a safe and effective treatment option for metastatic renal cell carcinoma
BackgroundAlthough a combination of immune checkpoint inhibitors (ICIs) is recommended as the first line treatment option for metastatic renal cell...
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Win or loss? Combination therapy does improve the oncolytic virus therapy to pancreatic cancer
Pancreatic cancer (PC) is a growing global burden, remaining one of the most lethal cancers of the gastrointestinal tract. Moreover, PC is resistant...
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Oncolytic mineralized bacteria as potent locally administered immunotherapeutics
Oncolytic bacteria can trigger innate immune activity. However, the antitumour efficacy of inactivated bacteria is poor, and attenuated live bacteria...
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Protocols to Manufacture an Oncolytic Measles Virus–Sensitive Immunocompetent Mouse Model of Medulloblastoma
Oncolytic virotherapy translational research in the current era is heavily focused on the interaction of the immune system and tumor microenvironment...