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Oncolytic virotherapy evolved into the fourth generation as tumor immunotherapy
BackgroundOncolytic virotherapy (OVT) is a promising anti-tumor modality that utilizes oncolytic viruses (OVs) to preferentially attack cancers...
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Modifying oncolytic virotherapy to overcome the barrier of the hypoxic tumor microenvironment. Where do we stand?
Viruses are completely dependent on host cell machinery for their reproduction. As a result, factors that influence the state of cells, such as...
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The role of oncolytic virotherapy and viral oncogenes in the cancer stem cells: a review of virus in cancer stem cells
Cancer Stem Cells (CSCs) are the main “seeds” for the initiation, growth, metastasis, and recurrence of tumors. According to many studies, several...
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Fast Track Adaptation of Oncolytic Coxsackie B3 Virus to Resistant Colorectal Cancer Cells - a Method to Personalize Virotherapy
BackgroundThe efficacy of oncolytic viruses (OV) in cancer treatment depends on their ability to successfully infect and destroy tumor cells....
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Improving the therapeutic efficacy of oncolytic viruses for cancer: targeting macrophages
Oncolytic viruses (OVs) for cancer treatment are in a rapid stage of development, and the direct tumor lysis and activation of a comprehensive host...
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Quantitative imaging of apoptosis following oncolytic virotherapy by magnetic resonance fingerprinting aided by deep learning
Non-invasive imaging methods for detecting intratumoural viral spread and host responses to oncolytic virotherapy are either slow, lack specificity...
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Cutting both ways: the innate immune response to oncolytic virotherapy
Oncolytic viruses (OVs), above and beyond infecting and lysing malignant cells, interact with the immune system in complex ways that have important...
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Cell type-specific response of colon cancer tumor cell lines to oncolytic HSV-1 virotherapy in hypoxia
BackgroundNovel strategies are required since the hypoxic tumor microenvironment is one of the important impediments for conventional cancer therapy....
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Personalizing Oncolytic Immunovirotherapy Approaches
Development of successful cancer therapeutics requires exploration of the differences in genetics, metabolism, and interactions with the immune...
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Oncolytic DNX-2401 virotherapy plus pembrolizumab in recurrent glioblastoma: a phase 1/2 trial
Immune-mediated anti-tumoral responses, elicited by oncolytic viruses and augmented with checkpoint inhibition, may be an effective treatment...
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The efficacy and safety assessment of oncolytic virotherapies in the treatment of advanced melanoma: a systematic review and meta-analysis
BackgroundThe efficacy and safety of oncolytic virotherapies in the treatment of advanced melanoma still remains controversal. It is necessary to...
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Enhancing cancer therapy: the integration of oncolytic virus therapy with diverse treatments
As one of the significant challenges to human health, cancer has long been a focal point in medical treatment. With ongoing advancements in the field...
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Oncolytic Viral Therapy for Malignant Glioma and Their Application in Clinical Practice
Glioblastoma is the most common primary malignant brain tumor in adults and outcomes remain poor despite the current standard of care multimodal...
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Improving antitumor efficacy via combinatorial regimens of oncolytic virotherapy
As a promising therapeutic strategy, oncolytic virotherapy has shown potent anticancer efficacy in numerous pre-clinical and clinical trials....
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Repurposing of Zika virus live-attenuated vaccine (ZIKV-LAV) strains as oncolytic viruses targeting human glioblastoma multiforme cells
Glioblastoma multiforme (GBM) is the most common malignant primary brain cancer affecting the adult population. Median overall survival for GBM...
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Oncolytic T-VEC virotherapy plus neoadjuvant chemotherapy in nonmetastatic triple-negative breast cancer: a phase 2 trial
Talimogene laherparepvec (T-VEC) is an oncolytic virus hypothesized to enhance triple-negative breast cancer (TNBC) responses to neoadjuvant...
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SOCS3 inhibiting JAK-STAT pathway enhances oncolytic adenovirus efficacy by potentiating viral replication and T-cell activation
Oncolytic viruses (OVs) are emerging as a potentially useful treatment for malignancies due to the capabilities of direct oncolysis and immune...
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Vaccines and Oncolytic Virus for the Treatment of Lung Cancer
Lung cancer is the most prevalent cause of cancer deaths in men and women, with a 5-year survival rate of fewer than 15% due to late-stage diagnosis...
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Long-term activation of anti-tumor immunity in pancreatic cancer by a p53-expressing telomerase-specific oncolytic adenovirus
BackgroundPancreatic cancer is an aggressive, immunologically “cold” tumor. Oncolytic virotherapy is a promising treatment to overcome this problem....
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Nano-modified viruses prime the tumor microenvironment and promote the photodynamic virotherapy in liver cancer
BackgroundAs of 2020, hepatocellular carcinoma (HCC), a form of liver cancer, stood as the third most prominent contributor to global cancer-related...
