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A role for the circadian transcription factor NPAS2 in the progressive loss of non-rapid eye movement sleep and increased arousal during fentanyl withdrawal in male mice
RationaleSynthetic opioids like fentanyl are contributing to the rise in rates of opioid use disorder and drug overdose deaths. Sleep dysfunction and...
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Sleep features of nocturnal enuresis: relationship between rapid eye movement sleep latency prolongation and nocturnal enuresis
Nocturnal enuresis, or bed wetting, is the involuntary urination during sleep. One of its causes is difficulty awakening during sleep, suggesting a...
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Cortical regulation of two-stage rapid eye movement sleep
Rapid eye movement (REM) sleep is a sleep state characterized by skeletal muscle paralysis and cerebral cortical activation. Yet, global cortical...
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Rapid Eye Movement Sleep and Dream Sleep
Consciousness is an attribute of the brain, by the brain, and for the brain. Our understanding of neurophysiological mechanism of consciousness is...
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Rapid eye movement sleep behavior disorder is associated with decreased quality of life and stigma in people with Parkinson’s disease
BackgroundIndividuals with Parkinson’s disease (PD) may present with rapid eye movement sleep behavior disorder (RBD). We therefore investigated the...
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Study on the circadian rhythm and sleep state characteristics of patients with acute cerebral infarction accompanied by sleep-breathing disorders
There is limited research on the circadian rhythm and sleep state in patients with acute cerebral infarction (ACI) accompanied by sleep-breathing...
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Altered connectivity in the cognitive control-related prefrontal cortex in Parkinson’s disease with rapid eye movement sleep behavior disorder
Rapid eye movement sleep behavior disorder (RBD) frequently occurs in Parkinson’s disease (PD), however, the exact pathophysiological mechanism is...
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Sleep and circadian rhythmicity as entangled processes serving homeostasis
Sleep is considered essential for the brain and body. A predominant concept is that sleep is regulated by circadian rhythmicity and sleep...
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Impact of REM Sleep on Sleep Disorders: Current Perspectives
Sleep is a complex process characterized by different stages, including rapid eye movement (REM) and non-rapid eye movement (NREM) sleep. Throughout...
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Disrupted sleep-wake regulation in the MCI-Park mouse model of Parkinson’s disease
Disrupted sleep has a profound adverse impact on lives of Parkinson’s disease (PD) patients and their caregivers. Sleep disturbances are exceedingly...
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Older adults at greater risk for Alzheimer’s disease show stronger associations between sleep apnea severity in REM sleep and verbal memory
BackgroundObstructive sleep apnea (OSA) increases risk for cognitive decline and Alzheimer’s disease (AD). While the underlying mechanisms remain...
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Absence of multiple sleep-onset rapid eye movement periods (SOREMPs) is not a specific feature of patients with pathological sleep prolongation
PurposeMultiple sleep-onset rapid eye movement periods (SOREMPs) are involved in the pathophysiology of narcolepsy, but it is not clear whether the...
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Prefrontal cortical regulation of REM sleep
Rapid eye movement (REM) sleep is accompanied by intense cortical activity, underlying its wake-like electroencephalogram. The neural activity...
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Restricted truncal sagittal movements of rapid eye movement behaviour disorder
Unlike sleep-walkers, patients with rapid-eye-movement-behaviour disorder (RBD) rarely leave the bed during the re-enactment of their dreams. RBD...
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Crucial role of TFAP2B in the nervous system for regulating NREM sleep
The AP-2 transcription factors are crucial for regulating sleep in both vertebrate and invertebrate animals. In mice, loss of function of the...
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Effects of Sleep Deprivation and Experience on Sleep Characteristics and Memory Formation Based on EEG Analysis
Sleep is believed to play an important role in cognitive functions. The underlying mechanisms of the relationship between the effects of waking...
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Somatostatin neurons in prefrontal cortex initiate sleep-preparatory behavior and sleep via the preoptic and lateral hypothalamus
The prefrontal cortex (PFC) enables mammals to respond to situations, including internal states, with appropriate actions. One such internal state...
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Neuro-orchestration of sleep and wakefulness
Although considered an inactive state for centuries, sleep entails many active processes occurring at the cellular, circuit and organismal levels....
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Strength of ensemble learning in automatic sleep stages classification using single-channel EEG and ECG signals
AbstractHealthy sleep plays an essential role in human daily life. Classification of sleep stages is a crucial tool for assisting physicians in...
