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1. Regulation of N-type calcium channels by nociceptin receptors and its possible role in neurological disorders

   Activation of nociceptin opioid peptide receptors (NOP, a.k.a. opioid-like receptor-1, ORL-1) by the ligand nociceptin/orphanin FQ, leads to G...

   Emanuelle Sistherenn Caminski, Flavia Tasmin Techera Antunes, ... Gerald W. Zamponi in Molecular Brain

   Article Open access 24 November 2022
   

2. Structure-Based SAR in the Design of Selective or Bifunctional Nociceptin (NOP) Receptor Agonists

   The nociceptin opioid receptor (NOP), the fourth member of the opioid receptor family, and its endogenous peptide ligand, nociceptin or orphanin FQ...

   Michael E. Meyer, Arpit Doshi, ... Nurulain T. Zaveri in The AAPS Journal

   Article 11 May 2021
   

3. Involvement of the nociceptin opioid peptide receptor in morphine-induced antinociception, tolerance and physical dependence in female mice

   Nociceptin opioid peptide (NOP) receptor modulates pain transmission and is considered a prospective target for pain management. Under acute pain...

   **ao-Qing Hao, Zhi-Yuan Wang, ... ** Li in Metabolic Brain Disease

   Article 16 September 2021
   

4. Endogenous Opioids From Basic Science to Biopsychosocial Applications

   This new volume provides a scientifically based exploration of the multifaceted world of endogenous opioids, including endorphins, enkephalins,...

   Patrick L. Kerr, Cristian Sirbu, John M. Gregg in Advances in Neurobiology

   Book 2024
   

5. Fear expression is reduced after acute and repeated nociceptin/orphanin FQ (NOP) receptor antagonism in rats: therapeutic implications for traumatic stress exposure

   Rationale

   Evaluation of pharmacotherapies for acute stress disorder (ASD) or post-traumatic stress disorder (PTSD) is challenging due to robust...

   Rachel M. Taylor, Isaac H. Jeong, ... Emily G. Lowery-Gionta in Psychopharmacology

   Article 25 June 2020
   

6. Activation of NOP receptor increases vulnerability to stress: role of glucocorticoids and CRF signaling

   Rationale

   Recently, we demonstrated that the activation of the nociceptin/orphanin FQ (N/OFQ) receptor (NOP) signaling facilitates depressive-like...

   Victor A. D. Holanda, Raissa N. de Almeida, ... Elaine C. Gavioli in Psychopharmacology

   Article 25 January 2024
   

7. Effects of Non-Opiate Analogue of Leu-Enkephalin on the Ion Currents, Number of Nucleoli, and p53 Expression in Isolated Cardiomyocytes of Albino Rats

   Acute exposure of isolated ventricular cardiomyocytes to non-opiate analogue of leu-enkephalin (NALE peptide: Phe-D-Ala-Gly-Phe-Leu-Arg) in a...

   E. N. Sazonova, I. A. Gusev, T. S. Filatova in Bulletin of Experimental Biology and Medicine

   Article 01 August 2023

8. Interactions Between Endogenous Opioids and the Immune System

   The endogenous opioid system, which consists of opioid receptors and their ligands, is widely expressed in the nervous system and also found in the...

   Wei Du in Endogenous Opioids

   Chapter 2024
   

9. Opioid Receptor Regulation of Neuronal Voltage-Gated Calcium Channels

   Neuronal voltage-gated calcium channels play a pivotal role in the conversion of electrical signals into calcium entry into nerve endings that is...

   Norbert Weiss, Gerald W. Zamponi in Cellular and Molecular Neurobiology

   Article 08 June 2020
   

10. N/OFQ modulates orofacial pain induced by tooth movement through CGRP-dependent pathways

    Background

    Nociceptin/orphanin FQ (N/OFQ) has been revealed to play bidirectional roles in orofacial pain modulation. Calcitonin gene-related peptide...

    **nyu Yan, Han Han, ... Wenli Lai in BMC Neuroscience

    Article Open access 09 April 2021
    

11. Effect of nociceptin on insulin release in normal and diabetic rat pancreas

    Nociceptin (NC), also known as Orphanin FQ, is a brain peptide involved in the regulation of pain, but its role in the endocrine pancreas is poorly...

    Ernest Adeghate, Zulqarnain Saeed, ... Ernest A. Adeghate in Cell and Tissue Research

    Article 15 August 2018
    

12. Nociceptin/orphanin FQ modulates energy homeostasis through inhibition of neurotransmission at VMN SF-1/ARC POMC synapses in a sex- and diet-dependent manner

    Background

    Orphanin FQ (aka nociceptin; N/OFQ) binds to its nociceptin opioid peptide (NOP) receptor expressed in proopiomelanocortin (POMC) neurons...

    Jennifer Hernandez, Carolina Fabelo, ... Edward J. Wagner in Biology of Sex Differences

    Article Open access 12 February 2019
    

13. Ciliary Neurotrophic Factor (CNTF), a Pleiotropic Cytokine: Potential Biomarker of Brain Diseases?

    Abstract

    Ciliary neurotrophic factor (CNTF) is a pluripotent neurotrophic factor with a high neuroprotective potential, a neurocytokine that has shown...

    A. A. Gudkova in Neurochemical Journal

    Article 01 March 2024

14. A Fentanyl Analogue That Activates u-Opioid Receptors in Acidified Tissues Inhibits Colitis Pain without Opioid Side Effects

    Opioid agonists are effective analgesics for treating visceral pain but their use is limited by their on-target side effects, such as constipation,...

    Nestor N. Jimenez-Vargas, Claudius E. Degro, ... Stephen J. Vanner in Visceral Pain

    Chapter 2023
    

15. Opioid Peptides and Their Receptors

    Since the discovery of opioid receptors and their endogenous ligands named opioid peptides, it has been established that opiates exert their effects...

    Ryszard Przewlocki in Neuroscience in the 21st Century

    Living reference work entry 2022
    

16. Opioid Peptides and Their Receptors

    Since the discovery of opioid receptors and their endogenous ligands named opioid peptides, it has been established that opiates exert their effects...

    Ryszard Przewlocki in Neuroscience in the 21st Century

    Reference work entry 2022
    

17. Opioids and Opiates: Pharmacology, Abuse, and Addiction

    This chapter presents an overview of the opioid system consisting of a wide variety of endogenous and exogenous ligands, as well as several receptor...

    Silvia L. Cruz, Vinicio Granados-Soto in Neuroscience in the 21st Century

    Reference work entry 2022
    

18. Opioid Receptors and Neuronal Signal Transduction

    This chapter provides information on the classification, structure, and properties of the main opioidOpioids receptor subtypes, their canonical and...

    César J. Carranza-Aguilar, Zyanya P. Espinosa-Riquer, ... Silvia L. Cruz in Opioids

    Chapter 2022
    

19. Effects of Neonatal Administration of Non-Opiate Analogues of Leu-Enkephalin to Heart Tissue Homeostasis of Prepubertal Albino Rats Exposed to Hypoxia

    Hypobaric hypoxia (pO ₂ 65 mm Hg, duration 4 h) induced a significant increase in the number of cardiomyocytes expressing р53, beclin-1, endothelial...

    E. N. Sazonova, I. A. Gusev, ... S. V. Vdovenko in Bulletin of Experimental Biology and Medicine

    Article 23 June 2022

20. Neuromodulation in Parkinson’s disease targeting opioid and cannabinoid receptors, understanding the role of NLRP3 pathway: a novel therapeutic approach

    Parkinson's disease (PD) is a prevalent neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia...

    Md Reyaz Alam, Shamsher Singh in Inflammopharmacology

    Article 15 June 2023