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Next-Generation Anti-TNFα Agents: The Example of Ozoralizumab
Biologic therapy involving anti-tumor necrosis factor-α (anti-TNFα) agents has fundamentally changed the management of patients with immune-mediated...
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Clinical applications of metagenomics next-generation sequencing in infectious diseases
Infectious diseases are a great threat to human health. Rapid and accurate detection of pathogens is important in the diagnosis and treatment of...
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The next generation of evidence-based medicine
Recently, advances in wearable technologies, data science and machine learning have begun to transform evidence-based medicine, offering a...
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Zurletrectinib is a next-generation TRK inhibitor with strong intracranial activity against NTRK fusion-positive tumours with on-target resistance to first-generation agents
BackgroundWhile NTRK fusion-positive cancers can be exquisitely sensitive to first-generation TRK inhibitors, resistance inevitably occurs, mediated...
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Next-generation data filtering in the genomics era
Genomic data are ubiquitous across disciplines, from agriculture to biodiversity, ecology, evolution and human health. However, these datasets often...
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Recommendations for reporting tissue and circulating tumour (ct)DNA next-generation sequencing results in non-small cell lung cancer
Non-small cell lung cancer is a heterogeneous disease and molecular characterisation plays an important role in its clinical management....
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Bridging live-cell imaging and next-generation cancer treatment
By providing spatial, molecular and morphological data over time, live-cell imaging can provide a deeper understanding of the cellular and signalling...
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Empowering Next-Generation Health Professionals with Futures Thinking and Strategic Foresight Skills
It is crucial to equip our next-generation healthcare professionals with futures thinking and strategic foresight skills as they confront the demands...
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In search of a pan-coronavirus vaccine: next-generation vaccine design and immune mechanisms
Members of the coronaviridae family are endemic to human populations and have caused several epidemics and pandemics in recent history. In this...
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Periodic solutions in next generation neural field models
We consider a next generation neural field model which describes the dynamics of a network of theta neurons on a ring. For some parameters the...
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Regulation of endothelial function by cigarette smoke and next-generation tobacco and nicotine products
Cigarette smoking is the most important avoidable cardiovascular risk factor. It causes endothelial dysfunction and atherosclerosis and increases the...
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Next-Generation Sequencing
The next-generation sequencing platforms can generate a large amount of high-throughput sequencing data in a short span of time. Reference-based...
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Application of next-generation imaging in biochemically recurrent prostate cancer
BackgroundBiochemical recurrence (BCR) following primary interventional treatment occurs in approximately one-third of patients with prostate cancer...
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New Variants Identified by Next-Generation Sequencing in Polycystic Kidney Disease Patients
Polycystic kidney disease (PKD) is a common inherited disease characterized by multiple cysts in kidneys and various extra renal manifestations....
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Apolipoprotein E in Alzheimer’s disease trajectories and the next-generation clinical care pathway
Alzheimer’s disease (AD) is a complex, progressive primary neurodegenerative disease. Since pivotal genetic studies in 1993, the ε4 allele of the...
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Advancements in Rift Valley fever vaccines: a historical overview and prospects for next generation candidates
Rift Valley fever (RVF) is a zoonotic viral disease transmitted by mosquitoes and causes abortion storms, fetal malformations, and newborn animal...
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Re: “Next generation sequencing in neonatology: what does it mean for the next generation?”
Available evidence does not support limiting the use of rapid or ultra-rapid exome or genome sequencing in critically ill neonates to cases of...
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Next generation sequencing in neonatology: what does it mean for the next generation?
Rapid whole genome sequencing (WGS) and whole exome sequencing (WES), sometimes referred to as “next generation sequencing” (NGS) are now recommended...
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Diagnostic strategy of metagenomic next-generation sequencing for gram negative bacteria in respiratory infections
ObjectiveThis study aims to identify the most effective diagnostic method for distinguishing pathogenic and non-pathogenic Gram-negative bacteria...
