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Artificial intelligence for natural product drug discovery
Developments in computational omics technologies have provided new means to access the hidden diversity of natural products, unearthing new potential...
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Natural Product Based Drug Discovery Against Human Parasites Opportunities and Challenges
This book comprehensively reviews current and novel treatment strategies against human parasites, including protozoans and helminths, using natural...
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Natural Product-based Synthetic Drug Molecules in Alzheimer's Disease Therapeutic & Theranostic Agents
This book illustrates the importance of natural products as the source for the development of novel drugs for the treatment of neurodegenerative...
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Multicomponent Reactions for the Synthesis of Natural Products and Natural Product-Like Libraries
Multicomponent reactions involve at least three starting materials that are combined in a single operation and are convergent, atom-economic, and...
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Pathway to Register Natural Product-Derived Therapeutics
Natural products (NPs) are biochemical compounds or molecules produced by living organisms. They are obtained from diverse sources ranging from small...
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Cyclodextrin inclusion complex of a multi-component natural product by hot-melt extrusion
This study aimed to investigate whether hot-melt extrusion (HME) processing can promote molecular encapsulation of a multi-component natural product...
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Natural Product-Based Anti-Viral Agents Against RNA Viruses: An Important Strategy for Pandemic Preparedness
Anthropogenic factors and climate changes result in the emergence and re-emergence of infectious diseases. Viruses are one of the major causative...
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A case history in natural product-based drug discovery: discovery of vorapaxar (Zontivity™)
Vorapaxar (Zontivity™) is an FDA approved antiplatelet agent that blocks platelet activation via protease activated receptor-1 (PAR-1), also known as...
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Optimization of clofibrate with natural product sesamol for reducing liver injury induced by acetaminophen
Acetaminophen (APAP), which is widely used for the treatment of analgesic-antipyretic as the first-line drug, can cause extensive hepatic injury and...
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Natural Product Formulations to Overcome Poor ADMET Properties
Many of the human needs, including medicines, have been fulfilled by nature. Medicinal plants have been a source of myriad natural therapeutic...
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Complete Genome Sequence of Streptomyces sp. HP-A2021, a Promising Bacterium for Natural Product Discovery
Streptomyces are one of the most prolific sources of bioactive and structurally diverse secondary metabolites for natural product drug discovery....
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Structure based virtual screening of natural product molecules as glycosidase inhibitors
Objective of the present investigation comprised of the application of in silico methods to discover novel natural product (NP) based potential...
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Antitumor mechanisms and future clinical applications of the natural product triptolide
Triptolide (TPL) is a compound sourced from Tripterygium wilfordii Hook. F., a traditional Chinese medicinal herb recognized for its impressive...
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Natural Product-Based Drug Designing for Treatment of Human Parasitic Diseases
Medicinal plants are the source of various therapeutic agents, including crude extracts and pharmacologically active compounds. Many novel targets...
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Evaluating the Effect of Microcrystalline Cellulose Variations on Tablet Quality of Natural Plant Product Using a Design of Experiment Approach
Microcrystalline cellulose (MCC) of different grades from different manufacturers differ in particulate and powder properties significantly. The...
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The natural product dehydrocurvularin induces apoptosis of gastric cancer cells by activating PARP-1 and caspase-3
The natural product dehydrocurvularin (DSE2) is a fungal-derived macrolide with potent anticancer activity, but the mechanism is still unclear. We...
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Attention-deficit/hyperactivity disorder and inflammation: natural product-derived treatments—a review of the last ten years
ObjectiveAttention-deficit hyperactivity disorder (ADHD) is a psychiatric disorder characterized by symptoms of inattention, hyperactivity, and...
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Antiviral Natural Products, Their Mechanisms of Action and Potential Applications as Sanitizers and Disinfectants
Plant extracts, natural products and plant oils contain natural virucidal actives that can be used to replace active ingredients in commercial...
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A search for potential anti-HIV phytoconstituents from the natural product repository
A chronic, life threatening and immuno-suppressing malady caused by Human immunodeficiency virus (HIV) is formally known as Acquired Immune...
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Hesperidin/Salinomycin Combination; a Natural Product for Deactivation of the PI3K/Akt Signaling Pathway and Anti-Apoptotic Factors in KG1a Cells
AML is a highly aggressive malignant clonal disease of hematopoietic origin. Hesperidin as a polyphenol glycoside, Activates the apoptotic pathway...
