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Mutagenetic and anti-allergic studies for evaluation of extracts of Coptis Rhizome produced by an artificial hydroponic system
As a part of the investigation of the safety and efficacy of the cultivated Coptis japonica rhizome extracts using an artificial hydroponic...
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Metabolite-Associated Disease Conditions
As a result of an imbalance between activation and detoxification metabolisms, reactive chemical intermediates and oxidative stress occur, leading to...
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Total mutational load and clinical features as predictors of the metastatic status in lung adenocarcinoma and squamous cell carcinoma patients
BackgroundRecently, extensive cancer genomic studies have revealed mutational and clinical data of large cohorts of cancer patients. For example, the...
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Integrating Ultraweak Photon Emission in Mitochondrial Research
Once considered exclusively as the cell’s energy producers, mitochondria are now recognized to perform multiple essential functions beyond energy...
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“Deficiency in ELF4, X-Linked”: a Monogenic Disease Entity Resembling Behçet’s Syndrome and Inflammatory Bowel Disease
Defining monogenic drivers of autoinflammatory syndromes elucidates mechanisms of disease in patients with these inborn errors of immunity and can...
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Application of CRISPR-Cas9 for Functional Analysis in A. mexicanus
Establishing genotype–phenotype relationships is critical for understanding the genetic architecture underlying trait evolution. While functional...
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Co-expression of low-risk HPV E6/E7 and EBV LMP-1 leads to precancerous lesions by DNA damage
BackgroundLow-risk human papillomavirus (HPV), such as types 6 and 11, is considered non-oncogenic, but these types have been detected in oral cancer...
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Human autoinflammatory disease reveals ELF4 as a transcriptional regulator of inflammation
Transcription factors specialized to limit the destructive potential of inflammatory immune cells remain ill-defined. We discovered loss-of-function...
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Oxidative stress mediated cytogenotoxicological effects of phytol in wistar albino rats
Phytol (PHY), a diterpenoid, is known for its various bio-pharmacological activities. However, its toxicological profile has yet to be evaluated. The...
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In Vitro Propagation and Biotechnological Improvement Strategies of Plants with High-Intensity Sweetener and Anti-Diabetic Activities
Diabetes mellitus is an endocrine and metabolic disease with high prevalence worldwide. Moreover, sugar intake has increased in the last decades...
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Peptide-Modified Gemini Surfactants: Preparation and Characterization for Gene Delivery
Diquaternary ammonium-based gemini surfactants have been investigated widely as nonviral gene delivery systems. These unique cationic lipids have...
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Protein–Protein Docking in Drug Design and Discovery
Protein–protein interactions (PPIs) are responsible for a number of key physiological processes in the living cells and underlie the pathomechanism...
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B-chromosomes and the plasticity of the species
The possible role of the population variability in the number and morphological types of B-chromosomes in the plasticity of the species is...
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Immunity, inflammation and cancer: a leading role for adenosine
Cancer is a complex disease that is dictated by both cancer cell-intrinsic and cell-extrinsic processes. Adenosine is an ancient extracellular...
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Challenges in Controlling and Eliminating Schistosomiasis
Schistosomiasis, a common intravascular infection caused by parasitic Schistosoma trematode worms, is one of the most prevalent of the tropical...
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Models of RNA virus evolution and their roles in vaccine design
Viruses are fast evolving pathogens that continuously adapt to the highly variable environments they live and reproduce in. Strategies devoted to...
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A specific box switches the cell fate determining activity of XOTX2 and XOTX5b in the Xenopus retina
BackgroundOtx genes, orthologues of the Drosophila orthodenticle gene ( otd ), play crucial roles in vertebrate brain development. In the Xenopus eye, Xotx2...
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HDAC Inhibitors
Natural and synthetic inhibitors of histone deacetylases (HDACs) have not only contributed to the discovery of HDAC enzyme molecules and the...