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Mitochondrial DNA Profiling
Mitochondrial DNA (mtDNA) is a versatile tool in understanding the clinical and non-clinical aspects attributed by the nucleotide sequences. The...
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The Protective Mechanism of TFAM on Mitochondrial DNA and its Role in Neurodegenerative Diseases
Mitochondrial transcription factor A (TFAM) is a mitochondrial protein encoded by nuclear genes and transported from the cytoplasm to the...
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Global metabolic alterations in colorectal cancer cells during irinotecan-induced DNA replication stress
BackgroundMetabolic adaptations can allow cancer cells to survive DNA-damaging chemotherapy. This unmet clinical challenge is a potential...
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Mitochondrial DNA Mutations in Cardiovascular Diseases
Early prevention of the development and timely diagnosis of cardiovascular system diseases are some of the main problems in modern cardiology. One...
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Molecular basis for maternal inheritance of human mitochondrial DNA
Uniparental inheritance of mitochondrial DNA (mtDNA) is an evolutionary trait found in nearly all eukaryotes. In many species, including humans, the...
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Mitochondrial DNA-triggered innate immune response: mechanisms and diseases
Various cellular stress conditions trigger mitochondrial DNA (mtDNA) release from mitochondria into the cytosol. The released mtDNA is sensed by the...
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Molecular mechanisms of mitochondrial DNA release and activation of the cGAS-STING pathway
In addition to constituting the genetic material of an organism, DNA is a tracer for the recognition of foreign pathogens and a trigger of the innate...
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DNA replication stress and mitotic catastrophe mediate sotorasib addiction in KRASG12C-mutant cancer
BackgroundSotorasib is the first KRAS G12C inhibitor approved by the US Food and Drug Administration for treating KRAS G12C -mutant non-small-cell lung...
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Plausible Role of Mitochondrial DNA Copy Number in Neurodegeneration—a Need for Therapeutic Approach in Parkinson’s Disease (PD)
Parkinson’s disease (PD) is an advancing age-associated progressive brain disorder which has various diverse factors, among them mitochondrial...
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Cellular and Molecular Responses to Mitochondrial DNA Deletions in Kearns-Sayre Syndrome: Some Underlying Mechanisms
Kearns-Sayre syndrome (KSS) is a rare multisystem mitochondrial disorder. It is caused by mitochondrial DNA (mtDNA) rearrangements, mostly...
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Cytosolic DNA initiates a vicious circle of aging-related endothelial inflammation and mitochondrial dysfunction via STING: the inhibitory effect of Cilostazol
Endothelial senescence, aging-related inflammation, and mitochondrial dysfunction are prominent features of vascular aging and contribute to the...
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Mitochondrial DNA Analysis in Population Isolates: Challenges and Implications for Human Identification
Purpose of ReviewMitochondrial DNA (mtDNA) plays an essential role in forensic science, aiding in human identification especially when dealing with...
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Modulating Mitochondrial DNA Heteroplasmy with Mitochondrially Targeted Endonucleases
Mitochondria, mainly known as energy factories of eukaryotic cells, also exert several additional signaling and metabolic functions and are today...
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Single-cell multi-omics of mitochondrial DNA disorders reveals dynamics of purifying selection across human immune cells
Pathogenic mutations in mitochondrial DNA (mtDNA) compromise cellular metabolism, contributing to cellular heterogeneity and disease. Diverse...
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Mitochondrial DNA mutation affects the pluripotency of embryonic stem cells with metabolism modulation
Mitochondria are the only organelles other than the nucleus harboring their DNA in mammalian cells. The mitochondrial DNA (mtDNA) mutation is the...
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Epigenetic reprogramming of mtDNA and its etiology in mitochondrial diseases
Mitochondrial functionality and its regulation are tightly controlled through a balanced crosstalk between the nuclear and mitochondrial DNA...
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Arsenic-Induced Cardiovascular Diseases and their Correlation with Mitochondrial DNA Copy Number, Deletion, and Telomere Length in Bangladeshi Population
Arsenic contamination is a global health concern, primarily through contaminated groundwater and its entry into the food chain. The association...
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Induced pluripotent stem cells: ex vivo models for human diseases due to mitochondrial DNA mutations
Mitochondria are essential organelles for cellular metabolism and physiology in eukaryotic cells. Human mitochondria have their own genome (mtDNA),...
