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Nanocomposite hydrogel microneedles: a theranostic toolbox for personalized medicine
Due to the severity and high prevalence of cancer, as well as its complex pathological condition, new strategies for cancer treatment and diagnostics...
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Progress in the Application of Microneedles in Eye Disorders and the Proposal of the Upgraded Microneedle with Spinule
PurposeIn the local administration methods for treating eye diseases, the application of microneedles has great potential due to the shortcomings of...
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Pharmaceutical and Immunological Evaluation of Cholera Toxin A1 Subunit as an Adjuvant of Hepatitis B Vaccine Microneedles
PurposeFor successful delivery of a solid vaccine formulation into the skin using microneedles, the solubility of an adjuvant should be considered...
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Safety of applying influenza-antigen-coated microneedles to rat skin and the antigen specific immune response in vivo
PurposeTechnological advancements and innovations in the use of microneedles for medicinal purposes are constantly emerging. To promote the marketing...
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Polymer-Coated Polymeric (PCP) Microneedles for Controlled Dermal Delivery of 5-Fluorouracil
Polymeric microneedles were prepared with Polyvinyl Pyrrolidone (PVP) K-30 using the mold casting technique. The core microneedles were coated with...
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A comparison of dissolving microneedles and transdermal film with solid microneedles for iloperidone in vivo: a proof of concept
Iloperidone (ILO) is a poorly soluble and bioavailable WHO-approved schizophrenia drug. Microneedles are a revolutionary delivery technology that...
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Fabrication of controlled-release silver nanoparticle polylactic acid microneedles with long-lasting antibacterial activity using a micro-molding solvent-casting technique
Most topical drug delivery techniques do not provide therapeutic concentrations for treatment of surgical site and other local infections and,...
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Imiquimod nanocrystal-loaded dissolving microneedles prepared by DLP printing
The utilization of 3D printing– digital light processing (DLP) technique, for the direct fabrication of microneedles encounters the problem of drug...
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Organic clay-based fast dissolving microneedles for efficient transdermal delivery of therapeutic proteins
PurposeMost protein drugs on the market are available in injectable dosage forms due to their metabolic instability and low membrane permeability,...
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Resveratrol nanocrystals based dissolving microneedles with highly efficient for rheumatoid arthritis
Rheumatoid arthritis (RA) is a common immune disease characterized mainly by erosive arthritis with extensive clinical sequelae. Resveratrol (Res)...
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Progress in Intradermal and Transdermal Gene Therapy with Microneedles
Gene therapy is one of the most widely studied treatments and has the potential to treat a variety of intractable diseases. The skin's limited...
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Sustained antigens delivery using composite microneedles for effective epicutaneous immunotherapy
AbstractAllergen-specific immunotherapy (SIT) is a desirable way of therapy for various allergic diseases such as food allergy (FA). However,...
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Transdermal Delivery of Baclofen Using Iontophoresis and Microneedles
Baclofen, a GABA b agonist, is used in the treatment of multiple sclerosis, a neurodegenerative disease. Currently available dosage forms to deliver...
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Fabrication of Polymeric Microneedles using Novel Vacuum Compression Molding Technique for Transdermal Drug Delivery
PurposeTo demonstrate the feasibility of vacuum compression molding as a novel technique for fabricating polymeric poly (D, L-lactic-co-glycolic...
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Minoxidil Nanosuspension-Loaded Dissolved Microneedles for Hair Regrowth
Minoxidil (MIN) is used topically to treat alopecia. However, its low absorption limits its use, warranting a new strategy to enhance its delivery...
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A comprehensive review of nanosuspension loaded microneedles: fabrication methods, applications, and recent developments
BackgroundNanosuspension-loaded microneedles (MNs) are an emerging and advanced strategy used extensively to formulate lipophilic molecules by...
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Separable and Inseparable Silk Fibroin Microneedles for the Transdermal Delivery of Colchicine: Development, Characterization, and Comparisons
Colchicine is the first-line option for both the treatment and prophylaxis of gout flares. However, due to potentially severe side effects, the...
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Fabrication and Characterization of Dissolving Microneedles for Transdermal Drug Delivery of Apomorphine Hydrochloride in Parkinson’s Disease
PurposeWe fabricated and characterized polyvinyl alcohol (PVA)-based dissolving microneedles (MNs) for transdermal drug delivery of apomorphine...
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Unravelling the role of microneedles in drug delivery: Principle, perspectives, and practices
In recent year, the research of transdermal drug delivery systems has got substantial attention towards the development of microneedles (MNs). This...
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A Review on Solid Microneedles for Biomedical Applications
Microelectromechanical system (MEMS)-based microneedles are an innovative way of drug delivery that increases the permeability of the skin. It...
